Browse > Article

Two Alkaloids from Ephedra aphylla growing in Egypt  

Abdel-Kader, Maged S. (Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria)
Kassem, Fahima F. (Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria)
Abdallah, Rokia M. (Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria)
Publication Information
Natural Product Sciences / v.9, no.2, 2003 , pp. 52-55 More about this Journal
Abstract
The aerial parts of Ephedra aphylla afforded two alkaloids belonging to two different classes. The first alkaloid, ephedradine C, belonging to the spermine alkaloid, a group characterized by its hypotensive effect. The other alkaloid, hordenine is a phenylalkylamine alkaloid isolated for the first time from Ephedra Species. The structures were elucidated by spectroscopic methods and the assignment of some carbons in ephedradine C was achieved based on 2 D-NMR experiments.
Keywords
Ephedra aphylla; Ephedraceae; alkaloids; isolation and identification;
Citations & Related Records

Times Cited By SCOPUS : 3
연도 인용수 순위
1 AI Khalil, S., Alkofahi, A., El Eisawi, D. and AI Shibib, A., Transtorine, a new quinoline alkaloid from Ephedra transitoria. J. Nat. Prod., 62, 1214 (1999)
2 DerMardersian, A., 'The Review of Natural Products', Reference Publications, Inc. St. Louis, Missouri, USA, 2001
3 Kabuto, C., Tamada, M., Endo, K. and Hikino, H., Structure of ephedradine C, a hypotensive principle of Ephedra roots. hypotensive Heterocycles, 14(3), 295-298 (1980)   DOI
4 McLaughlin, J. L., Cactus alkaloids VI. Identification of hordenine and N-methyltyramine in Ariocarpus fissuratus varieties fissuratus and lloydii. Lloydia, 32(3), 392-394 (1969)   PUBMED
5 Schroeder, D. R. and Stennitz, F. R., Hordenine and N-methyl-4-methoxyphen ethylamine from Eriogonum species. J. Nat. Prod., 47(3), 555-556 (1984)   DOI
6 Zhu, J. and Hesse, M., The spermine alkaloids of Chaenorhinum minus. Planta Med., 54(5) 430-433 (1988)   DOI   PUBMED
7 Hikino, H., Ogata, K., Konno, C. and Sato, S., Hypotensive actions of Ephedradines, macrocyclic spermine alkaloids of Ephedra roots. Planta Med., 48(4), 290-293 (1983)   DOI   ScienceOn
8 Starratt, A. N. and Caveney, S., Quinoline-2-carboxylic acids from Ephedra species. Phytochemistry, 42(5), 1477-1478 (1996)   DOI   ScienceOn
9 Barwell, C. J. and Blunden, G., Hordenine from the red alga Gigartina stellata. J. Nat. Prod., 44 (4), 500-502 (1981)   DOI
10 Breitmaier, E. and Voelter, W., 'Carbon-13 NMR Spectroscopy', 3rd Ed., VCH, Weinheim, Germany (1987)
11 Brossi, A. and Pecherer, B. Alkaloids containing a simple aromatic moiety in 'Chemistry of the Alkaloids', Pelletier S. W., Ed., Van Nostrand Reinhold, New York, 1970
12 Chao, L. R., Seguin, E., Tillequin, F. and Koch, M., New alkaloid glycosides from Selaginella doederleinii. J. Nat. Prod., 50(3), 422- 426 (1987)   DOI
13 Tamada, M., Endo, K., Hikino, H. and Kabuto, C., Structure of ephedradine A, a hypotensive principle of Ephedra roots. Tetrahedron lett., 10, 873-876 (1979)
14 Boulos, L., 'Flora of Egypt ', Al Hadara Publishing, Cairo, Egypt, Vol. 1, 1999
15 Caveney, S., Charlet, D. A., Freitag, H., Maier-Stolte, M. and Starratt, A. N., New observations on the secondary chemistry of world Ephedra (Ephedraceae). Am. J. Bot., 88(7), 1199-1208 (2001)   DOI   ScienceOn
16 Keller, W. J., Hordenine from Stapelia gigantean. J. Nat. Prod., 44(3), 366-367 (1981)   DOI
17 Nawwar, M. A.M., Barakat, H. H., Buddrus, J. and Linscheid, M., Alkaloidal, lignan and phenolic constituents of Ephedra alata. Phytochemistry, 24(4), 878-879 (1985)   DOI   ScienceOn
18 Pummangura, S. and McLaughlin, J. L., Cactus alkaloids XLVII. $\beta$-phenethylamines from the 'Missouri Pincushion' Coryphantha (Neobessya) missouriensis. J. Nat. Prod., 44(5), 614-616 (1981)   DOI