Browse > Article

Antitumor and Immunostimulating Activities of Acanthopanax sessiliflorus Fruits  

Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University, College of Pharmacy, Seoul National University)
Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University)
Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University)
Ji, Jun (Natural Products Research Institute, Seoul National University)
Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
Kim, Bak-Kwang (College of Pharmacy, Seoul National University)
Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
Publication Information
Natural Product Sciences / v.9, no.2, 2003 , pp. 112-116 More about this Journal
Abstract
The antitumor and immunostimulating activities of Acanthopanax sessiliflorus fruits were investigated. Polysaccharide isolated from this plant, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume in mice inoculated with Sarcoma-180 tumor cells. Polysaccharide was also demonstrated to exhibit phagocytosis-enhancing activity as measured by the carbon clearance in mice. Polysaccharide, when administered i.p. at 50 and 100 mg/kg/day for 3 consecutive days, exhibited a significant RCtr/RCc [the rate of regression coefficient of the animals teated (RCtr) to that of the control (RCc)], being 1.44 (PI = 1), 1.52 (PI = 2) which was approximately the same with that of enhancement of phagocytosis, its potency as expressed by the regression coefficient ratio of zymosan (RCtr/RCc = 1.55, PI = 2), a typical phagocytosis enhancer. Polysaccharide also caused a significant increase in the acid phosphatase activity representing lysosomal enzymes in macrophages at 1-100 ig/ml in vitro in compliance with in vivo results. These results suggest that the antitumor activity of polysaccharide might be related to the immunostimulating function.
Keywords
Acanthopanax sessiliflorus; Araliaceae; polysaccharide; antitumor activity; immunostimulating activity;
Citations & Related Records

Times Cited By SCOPUS : 4
연도 인용수 순위
1 Da Silva, B. P., Tostes, J. B. and Parente, J. P., Immunologically active polysaccharides from Centrosema pubescens. Fitoterapia 71,516-521 (2000)   DOI   ScienceOn
2 Kim, C. W. and Kim S. K., Studies on the constituents of seeds of Acanthopanax sessiliflorus Seemann. Kor. J. Pharmacogn. 18, 184-187 (1987)
3 Lee, S., Ji, J., Shin, K. H. and Kim, B.-K., Sessiline, a new nitrogenous compound from the fruits of Acanthopanax sessiliflorus. Planta Med. 68, 939-941 (2002)   DOI   ScienceOn
4 Shen, M. L., Zhai, S. K., Chen, H. L., Luo, Y. D., Tu, G. R. and Ou, D. W., Immunopharmacological effects of polysaccharides from Acanthopanax senticosus on experimental animals. Int. J. Immunopharmacol. 13, 549-554 (1991)   DOI   ScienceOn
5 Suzuki, I., Tanaka, H., Kinoshita, A., Oikawa, S. and Yadomae, T., Effect of orally administered $\beta$-glucan on macrophage function in mice. Int. J. Immunopharmacol. 12, 675-684 (1990)   DOI   ScienceOn
6 Wagner, H., Proksch, A., Riess-Maurer, I., Vollmar, A., Odenthal,S., Stuppner, H., Jurcic, K, Le, T. M. and Fang, J. N., Immunostimulating polysaccharides of higher plants. ArzneimForsch 35, 1069-1075 (1985)
7 Wong, C. K., Leung, K N., Fung, K P. and Choy, Y. M., Immuno-modulatory and anti-tumor polysaccharides form medicinal plants. J. Int. Med. Res. 22,299-312 (1994)   DOI
8 Borchers, A. T., Stern, J. S., Hackman, R. M., Keen, C. L. and Gershwin, M. E., Mushrooms, tumors, and immunity. Proc. Soc. Exp. BioI. Med. 221,281-293 (1999)   DOI   ScienceOn
9 Han, S. B., Park, S. H., Lee, K. H., Lee, C. W., Lee, S. H., Kim, H. C., Kim, Y. S., Lee, H. S. and Kim, H. M., Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells. Int. Immunopharmacol. 1, 1969-1978 (2001).   DOI   ScienceOn
10 Han, S. B., Kim, Y.H., Lee, C. W., Park, S. M., Lee, H. Y.,Ahn, K. S., Kim, I. H. and Kim, H. M., Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai. Immunophannacol. 40, 39-48 (1998)
11 Sugimachi, K., Maechara, Y., Ogawa, M., Kakegawa, T. and Tomira, M., Dose intensity of uracil and tegafur in postoperative chemotherapy for patients with poorly differentiated gastric cancer. Cancer Chemother. Pharmacol. 40, 233-238 (1997)   DOI   ScienceOn
12 Zhu, D., Recent advances on the active components in Chinese medicines. Abstr. Chin. Med. 1, 251-286 (1987)
13 Asilbekova, D. T., Gusakova, S. D. and Glushenkova, A. I., New hydroxy fatty acids of Acanthopanax sessiliflorus. Khim. Prir. Soed. 5, 616-619 (1991)
14 Wang, J. Z., Mao, X. J.,Ito, H. and Shimura, K., Immunomodulatory activity of polysaccharide from Acanthopanax obovatus roots. Planta Med. 57, 335-336 (1991)   DOI   ScienceOn
15 Kim, H. M., Han, S. B., Oh, G. T., Kim, Y. H., Hong, D. H., Hong, N. D. and Yoo, I. D., Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus. Int. J. Immunopharmacol. 18, 295-303 (1996)   DOI   ScienceOn
16 Wang, J. Z., Tsumura, H., Ma, N., Shimura, K and Ito, H., Biochemical and morphological alterations of macrophages and spleen cells produced by antitumor polysaccharide from Acanthopanax obovatus roots. Planta Med. 59, 54-58 (1993)   DOI   ScienceOn
17 Wasser, S. P., Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl. Microbiol. Biotechnol. 60, 258-274 (2002)   DOI   PUBMED   ScienceOn
18 Yook, C. S., Lee, D. H., Seo, Y.K and Ryu, K S., Studies on the constituents in the root bark of Acanthopanax sessiliflorus Seemann. Kor. J. Pharmacogn. 8,31-34 (1977)
19 Perry, L. M., 'Medicinal Plants of East and Southeast Asia', MIT press, Cambridge, Massachusetts and London, 1980, p. 41
20 Ro, H. S., Lee, S. Y. and Han, B. H., Studies on the lignan glycoside of Acanthopanax cortex. J. Pharm. Soc. Kor. 21, 8186 (1977)