Browse > Article

A Potential Cytotoxic Principle of Zingiber cassumunar  

Han, Ah-Reum (College of Pharmacy, Ewha Womans University)
Lee, Eun-Jin (College of Pharmacy, Ewha Womans University)
Min, Hye-Young (College of Pharmacy, Ewha Womans University)
Kim, Hyang-Rim (College of Pharmacy, Ewha Womans University)
Lee, Sang-Kook (College of Pharmacy, Ewha Womans University)
Seo, Eun-Kyoung (College of Pharmacy, Ewha Womans University)
Publication Information
Natural Product Sciences / v.9, no.2, 2003 , pp. 109-111 More about this Journal
Abstract
A bioassay-guided fractionation of the active chloroform extracts of the rhizomes of Zingiber cassumunar Roxb. led to the isolation of a potential cytotoxic principle, curcumin (1), along with two inactive compounds, (E)-4-(3',4'- dimethoxyphenyl)but-3-en-1-ol (2) and (E)-4- (3',4'-dimethoxyphenyl)but-3-en-1- yl acetate (3). Curcumin (1) showed a significant cytotoxicity against several human cancer cell lines $(Col2;\;2.30,\;A549;\;12.30,\;SNU638;\;IC_{50}\;18.80\;{\mu}g/ml)$.
Keywords
Zingiber cassumunar; Zingiberaceae; rhizome; curcumin; (E)-4-(3',4'-dimethoxyphenyl)but-3-en-l-ol; (E)-4-(3',4'-dimethoxyphenyl)but-3-en-l-yl acetate; cytotoxicity;
Citations & Related Records

Times Cited By SCOPUS : 4
연도 인용수 순위
1 Burkill I. H., A dictionary of the economic products of the Malay Peninsula, Vols 1 and 2, Kuala Lumpur, 1966
2 Masuda T., and Jitoe A., Phenylbutenoid monomers from the rhizomes of Zingiber cassumunar. Phytochemistry 39, 459-461 (1995)   DOI   ScienceOn
3 Masuda T., Jitoe A., and Nakatani N., Structures of cassumunin A, B, and C, new potent antioxidants from Zingiber cassumunar. Chem. Lett. 1, 189-192 (1993)
4 Lee, S. K., Cui., B., Mehta, R. R., Kinghorn, A. D., and Pezzuto, J. M., Cytostatic mechanism and antitumor potential of novel $^1H$-cyclopenta[b]benzofuran lignans isolated from Aglaia elliptica. Chemico-Biol. Interact. 115, 215-228 (1998)   DOI   ScienceOn
5 Ozaki Y., Kawahara N., and Harada M., Anti-inflammatory effect of Zingiber cassumunar Roxb. and its active principles. Chem. Pharm. Bull. 39, 2353-2356 (1991)   DOI   ScienceOn
6 Jitoe A., Masuda T., and Mabry T. J., Novel antioxidants, cassuunarin A, B, and C, from Zingiber cassumunar. Tetrahedron Lett. 35, 981-984 (1994)   DOI   ScienceOn
7 Jitoe A., Masuda T., and Nakatani N., Phenylbutenoid dimmers from the rhizomes of Zingiber cassumunar. Phytochemistry 32, 357-363 (1993)   DOI   ScienceOn
8 Tuntiwachwuttikul P., Pancharoen O., Jaipetch T., and Reutrakul V., Phenylbutanoids from Zingiber cassumunar. Phytochemistry 20, 1164-1165 (1981)   DOI   ScienceOn
9 Syu W.J., Shen C. C., Don M. J., Ou J. C, Lee G. H., and Sun C. M., Cytotoxicity of curcuminoids and some novel compounds from Curcuma zedoaria. J. Nat. Prod. 61, 1531-1534 (1998)   DOI   ScienceOn