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DNA Strand-Nicking Principles of Mucuna birdwoodiana  

Han, Ah-Reum (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University)
Mar, Woong-Chon (College of Pharmacy and Natural Products Research Institute, Seoul National University)
Seo, Eun-Kyoung (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University)
Publication Information
Natural Product Sciences / v.9, no.2, 2003 , pp. 105-108 More about this Journal
Abstract
During our research program to find DNA strand-scission agents from higher plants, the MeOH extracts of the stems of Mucuna birdwoodiana Tutcher. (Leguminosae) exhibited the most potent activity with an $IC_{50}$ value of $4.9\;{\mu}g/ml$. Thus, detailed laboratory investigation was performed, and led to the isolation of known compounds, $({\pm})$-catechin (1) and (-)-epicatechin(2) as active principles. Compounds 1 and 2 showed significant activity of DNA strand-scission with $IC_{50}$ values of 10.8 and $7.5\;{\mu}g/ml$, respectively (positive control, bleomycin: $IC_{50}\;3.3\;{\mu}g/ml$.
Keywords
DNA strand-scission; Mucuna birdwoodiana; Leguminosae; $({\pm})-catechin$; (-)-epicatechin;
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