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Anti-allergic Effect of Aqueous Extract of Stachys riederi var.japonica Miq.in vivo and in vitro  

Kim, Suk-Hyun (College of Pharmacy, Woosuk University)
Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Eom, Dong-Ok (College of Pharmacy, Woosuk University)
Park, Jeong-Suk (College of Pharmacy, Woosuk University)
Lim, Jong-Pil (College of Pharmacy, Woosuk University)
Kim, Sang-Yong (College of Agriculture, Jeonbuk National University)
Shin, Hye-Young (College of Pharmacy, Wonkwang University)
Kim, Sang-Hyun (Department of Physiology and Pharmacology, University of Georgia)
Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Publication Information
Natural Product Sciences / v.9, no.1, 2003 , pp. 44-48 More about this Journal
Abstract
The effect of aqueous extract of Stachys riederi var. japonica Miq. (Labiatae) (SRAE) on the immediate-type allergic reactions was investigated. SRAE was found to exhibit a inhibitory activity on the compound 48/80-induced systemic anaphylaxis in mice. SRAE inhibited the plasma histamine release induced by compound 48/80 in mice. In addition, SRAE also inhibited the passive cutaneous anaphylaxis reaction induced by IgE/anti-IgE in mice. The effect of SRAE on the histamine release from rat peritoneal mast cells (RPMC) was studied. SRAE inhibited the histamine release induced by compound 48/80 in RPMC. To clarify the mechanism of these inhibiting reactions, we investigated the effects of SRAE on cyclic AMP (cAMP). The level of cAMP in human leukemia cell line, HMC-1, when SRAE (1 mg/ml) was added, significantly increased compared with that of basal cells. These results indicate that SRAE may be beneficial in the treatment of immediate-type allergic reaction.
Keywords
Stachys riederi; anaphylaxis; compound 48/80; anti-DNP IgE; histamine; cyclic AMP;
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