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Sanguisorba officinalis Inhibits Immediate-type Allergic Reactions  

Kim, Sung-Hwa (College of Pharmacy, Woosuk University)
Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Eom, Dong-Ok (College of Pharmacy, Woosuk University)
Kim, Sang-Yong (College of Agriculture, Chonbuk National University)
Kim, Sang-Hyun (Department of Physiology and Pharmacology, University of Georgia)
Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Publication Information
Natural Product Sciences / v.8, no.4, 2002 , pp. 177-182 More about this Journal
Abstract
The effect of aqueous extract of Sanguisorba officinalis L. (Rosaceae) root (SOAE) on the immediate-type allergic reactions by anal therapy was investigated. SOAE (0.01 to 1 g/kg) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. When SOAE was pretreated at the same concentrations with systemic anaphylaxis, the plasma histamine levels were reduced in a dose-dependent manner. SOAE (0.1 and 1 g/kg) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. SOAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The level of cyclic AMP (cAMP) in RPMC, when SOAE (1 mg/ml) was added, transiently and significantly increased compared with that of basal cells. These results provide evidence that anal therapy of SOAE may be beneficial in the treatment of allergic diseases.
Keywords
Sanguisorba officinalis; anal therapy; anaphylaxis; compound 48/80; anti-DNP IgE; histamine; cyclic AMP;
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