Browse > Article

Anti-platelet Effect of the Phenolic Constituents Isolated from the Leaves of Magnolia obovata  

Pyo, Mi-Kyung (Natural Products Research Institute, Seoul National University)
Koo, Yean-Kyoung (Natural Products Research Institute, Seoul National University)
YunChoi, Hye-Sook (Natural Products Research Institute, Seoul National University)
Publication Information
Natural Product Sciences / v.8, no.4, 2002 , pp. 147-151 More about this Journal
Abstract
In the course of our work on anti-platelet constituents from plants, eight phenolic compounds, $({\pm})-syringaresinol$ (1), 4-hydroxybenzaldehyde (2), 4-hydroxybenzoic acid (3), vanillic acid (4), 4-hydroxy cinnamic acid (5), quercetin 3-O-rhamnoside (6), rutin (7), and quercetin $3-(2^G-rhamnosylrutinoside)$ (8) were isolated from the methanol extract of the leaves of Magnolia obovata. The compounds were identified based on the spectroscopic data. Compound 2, 3, 5, 6, 7 and 8 were isolated for the first time from genus Magnolia. 1 and 6 showed same order of inhibitory potencies as acetylsalicylic acid (ASA) to rat platelet aggregation induced by all the stimulators tested. The remaining six compounds showed only mild effects.
Keywords
Magnolia obovata; syringaresinol; 4-hydroxybenzaldehyde; 4-hydroxybenzoic acid; 4-hydroxy cinnamic acid; quercetin 3-O-rhamnoside; rutin; quercetin $3-(2^G-rhamnosylrutinoside)$; anti-platelet;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 10
연도 인용수 순위
1 Hasan, A., Ahmed, I., Jay, M., Voirin, B., Flavonoid glycosides and an anthraqumone from Rumex chalepensis, Phytochem 39(5), 1211-1213 (1995)   DOI   ScienceOn
2 Miyazawa, M., Kasahara, H. and Kameoka, H., Phenolic lignans from flower buds of Magnolia fargessii. Phytochem. 31(10), 3666-3668 (1992)   DOI   ScienceOn
3 Scott, K. N., Carbon-13 Nuclear magnetic resonance of biologically important aromatic acids. I. Chemical shifts of benzoic acid and derivatives, J. Am. Chem. Soc., 94(24), 8564-8568 (1972)   DOI   PUBMED
4 Vermes, B., Seligmann, O. and Wagner, H., Synthesis of biologically active tetrahydrofurofuranlignan-(syringin, Pinoresinol)-mono-and bis- glucosides, Phytochem. 30(9), 3087-3089 (1991)   DOI   ScienceOn
5 Chae, S. H., Kim, P. S., Cho, J. Y., Park, J. S., Lee, J. H., Yoo, E. S., Baik, K. U., Lee, J. S., Park, M. H., Isolation and identification of inhibitory compounds on TNF- production from Magnolia fargessi. Arch. Pham. Res. 21(1), 67-69 (1998)   DOI
6 Chen, C. L., Chang, H. M., Cowling, E. B., Aporphine alkaloids and lignans in heartwood of Liriodendron tulipifera. Phytochem. 15, 547-550 (1976)   DOI   ScienceOn
7 Sinakos, Z. and Caen, J. P., Platelet aggregation in mammalians (human, rat, rabbit, guinea-pig, horse, dog). A comparative study. J. Lab. Clin. Med., 17, 99-111 (1967)
8 Yun-Choi H. S., Park, K. M., Pyo, M. K., Epinephrine induced platelet aggregation in rat platelet-rich plasma, Throm. Res. 100, 511-518 (2000)   DOI   ScienceOn
9 Abegaz, B. M., Ngadjui, B. T., Dongo, E., Ngameni, B., Nindi, M. N., Bezabih, M., Chalcones and other consdtuents of Dorstenia prorepens and Dorstenia zenkeri. Phytochem. 59(8), 877-883 (2002)   DOI   ScienceOn
10 Champavier, Y., Allais, D. P., Chulia, A. J., and Kaouadji, M., Acetylated and non-acetylated flavonol triglycosides from Galega officinalis. Chem. Pharm. Bull. 48(2), 281-282 (2000)   DOI   ScienceOn
11 Yaguchi, H., Yosioka, I., Yamasaki, K., Kim, I. H., Studies on the constituents of the Gastrodia elata Blume. Chem. Parm. BuIl 29, 55-62 (1981)   DOI
12 Singh, V. P., Pandey, R., Yadav, B. and Pandey, V. B., Flavonoids of Cinnamomum tamala, Nat. Prod. Sci, 8(1), l8-17 (2002)   과학기술학회마을
13 Harborne, J. B. & Mabry, T. J., The Flavonoids: Advances in Research, Chapman and Hall Ltd, London NewYork, Index of ^1^3C-NMRspectra of flavonoids 62, 65, 1982
14 Chaves, N., Sosa, T., Alias, J. C., Escudero J. C., Identification and effects of interaction phytotoxic compounds from exudate of Cistus ladanifer leaves. J Chem EcoI, 27(3), 6116-6121 (2001)
15 Hanasaki, K., Nakano, T. and Arita, H., Two phasic generation of thromboxane A_2 by the action of collagen on rat platelets. Throm. Res. 46, 425-436 (1981)
16 Kayano, S., Kikuzaki, H., Fukutsuka, N., Mitani, T., Nakatani, N., Antioxidant activity of prune (Prunus domestica L.) constituents and a new synergist, J. Agric. Food Chem. 50(13), 3708-3712 (2002)   DOI   ScienceOn
17 Bourne, E. J., Macleod, N. J., Pridham, J. B., The identification of naturally occurring cinnamic acid derivatives. Phytochem. 2, 225-230 (1963)   DOI   ScienceOn
18 Callaway, D. J., The word of Magnolias, Timber press, Inc, Hong kong, pp. 86-8, 1994
19 Pan, J. X., Hensens, 0. D., Zink, D. L., Chang, M. N., and Hwang, S. B., Lignans with platelet activating factor antagonist activity from MaenoIia biondii. Phytochem, 26(25), 1377-1379 (1987)   DOI