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Cytotoxicity of Lignans from Lindera erytherocarpa Makino  

Lee, Sang-Myung (Korea Research Institute of Bioscience and Biotechnology)
Baek, Seung-Hwa (Korea Research Institute of Bioscience and Biotechnology)
Lee, Choong-Hwan (Korea Research Institute of Bioscience and Biotechnology)
Lee, Hyang-Burm (Korea Research Institute of Bioscience and Biotechnology)
Kho, Yung-Hee (Korea Research Institute of Bioscience and Biotechnology)
Publication Information
Natural Product Sciences / v.8, no.3, 2002 , pp. 100-102 More about this Journal
Abstract
Three lignans were isolated from a methanol extract of Lindera erytherocarpa Makino (Lauraceae) are evaluated in vitro cytotoxicity using three cancer cell line assay. The compounds were identified as methyllinderone (1), linderone (2), and kanakugiol (3) by spectroscopic methods. Amongst the compounds, methyllinderone (1) showed significant cytotoxicity against mouse melanoma (B16-FlO), human acetabulum fibrosarcoma (HT1080), and choronic myelogenous leukemia (K562) cancer cell lines with $ED_{50}$ values of 2.2, 2.5, 8.3 ${\mu}g/ml$, respectively.
Keywords
Lindera erytherocarpa Mak; methyllinderone; linderone; kanakugiol; cytotoxicity;
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Times Cited By SCOPUS : 2
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