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http://dx.doi.org/10.5657/fas.2002.5.4.308

Effect of Nonylphenol on Plasma Glutamate Oxaloacetate Transaminase (GOT) and Glutamate Pyruvate Transaminase (GPT) in the Juvenile Rockfish, Sebastes schlegeli  

Hwang Un-Gi (Department of Aquatic Life Medicine, Pukyong National University)
Kang Ju-Chan (Department of Aquatic Life Medicine, Pukyong National University)
Publication Information
Fisheries and Aquatic Sciences / v.5, no.4, 2002 , pp. 308-310 More about this Journal
Abstract
Effect of 4-nonylphenol (4-NP), endocrine disrupting compounds (EDCs), on glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) were investigated in the plasma of juvenile rockfish, Sebastes schlegeli. Fish were injected with 4­NP (10, 50, 100 and 200 mg/kg body weight) in $70\%$ ethanol twice at 3-day intervals and plasma sampling were extracted at 7 days after the last injection. Controls received solvent only. 4-NP significant increased GOT in a dose-dependent manner. GPT was markedly elevated to $61\%$ (P<0.05) and $82\%$ (P<0.01) than that of the control at the 4-NP doses of 100 and 200mg, respectively. These results suggest that the estrogenic activity of 4-NP increase plasma GOT and GPT by toxic effect on hepatocyte.
Keywords
4-Nonylphenol; EDCs; GOT; GPT; Juvenile rockfish;
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