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http://dx.doi.org/10.1007/s11814-013-0232-3

Enhanced skin delivery and characterization of rutin-loaded ethosomes  

Park, Soo Nam (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology)
Lee, Hye Jin (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology)
Gu, Hyun A (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology)
Publication Information
Korean Journal of Chemical Engineering / v.31, no.3, 2014 , pp. 485-489 More about this Journal
Abstract
We formulated rutin-loaded ethosomes and compared their vesicle size, loading efficiency, stability, and elasticity. In addition, an in vitro skin penetration experiment was performed. The results of the study indicated that ethosomes loaded with 0.005-0.03% rutin were stable during the four-week study period. Among them, those loaded with 0.03% rutin showed a vesicle size ($190.20{\pm}14.57nm$) and loading efficiency ($73.77%{\pm}0.01%$). Therefore, the in vitro skin penetration experiment was performed using 0.03% rutin-loaded ethosome. Compared to an ethanolic solution of rutin (44.16%), rutin-loaded liposome (37.80%), and a distilled water (DW) solution of rutin (18.31%), rutin-loaded ethosome ($93.31{\mu}g$; 61.30%) was superior in delivering rutin. Therefore, we suggest that ethosome loaded with 0.03% rutin enhance the skin penetration of rutin and may be used as a drug delivery system for natural cosmetic materials such as flavonoids.
Keywords
Ethosome; Rutin; Skin Penetration; Cosmetic Material; Elasticity;
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Times Cited By KSCI : 5  (Citation Analysis)
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