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http://dx.doi.org/10.4491/eer.2018.144

Simultaneous quantitative analysis of four isothiazolinones and 3-iodo-2-propynyl butyl carbamate in hygienic consumer products  

Heo, Jin Ju (Department of Civil and Environmental Engineering, Pusan National University)
Kim, Un-Jung (Department of Civil and Environmental Engineering, Pusan National University)
Oh, Jeong-Eun (Department of Civil and Environmental Engineering, Pusan National University)
Publication Information
Environmental Engineering Research / v.24, no.1, 2019 , pp. 137-143 More about this Journal
Abstract
In this study, extraction, clean-up and instrumental analytical conditions were optimized for identifying and quantifying methyl-, chloromethylbenzi-, octyl- isothiazolinone (MIT, CMIT, BIT, OIT) and 3-iodo-2-propynyl butyl carbamate (IPBC), widely used biocidal active ingredients in human hygiene consumer products. Accuracy of the developed ultrasonic assisted extraction method followed by HPLC/MS analysis for four isothiazolinones and IPBC ranged between 60.4% and 113% in various types of consumer product samples. Method detection limits ranged 0.011-0.034 mg/kg for wet wipes, 0.57-1.5 mg/kg for liquid detergent and 0.58-1.6 mg/kg for powder detergent. Wet wipes, powder and liquid detergents collected from local market in Korea were analyzed to demonstrate the applicability of the developed method. Even after the regulation of those compounds in wet wipes, CMIT, MIT and IPBC were still frequently detected from complementary wet wipes without brand labels which were distributed to customers at local retail shops and restaurants. The maximum observed concentrations of MIT and CMIT found in those complementary wet wipes were 70.2 mg/kg and 11.3 mg/kg, respectively.
Keywords
Biocidal active ingredient; Consumer products; Detergent; UAE-HPLC/MS; Wet wipes;
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  • Reference
1 "Biocide". Wikipedia [Internet]. c2016 [cited 13 March 2016]. Available from: http://www.en.wikipedia.org/wiki/Biocide.
2 Wittenberg JB, Canas BJ, Zhou W, Wang PG, Rua D, Krynitsky AJ. Determination of methylisothiazolinone and methylchloroisothiazolinone in cosmetic products by ultra high performance liquid chromatography with tandem mass spectrometry. J. Sep. Sci. 2015;38:2983-2988.   DOI
3 Rosero-Moreano M, Canellas E, Nerin C. Three-phase hollow-fiber liquid-phase microextraction combined with HPLC-UV for the determination of isothiazolinone biocides in adhesives used for food packaging materials. J. Sep. Sci. 2014;37:272-280.   DOI
4 c2016 [cited 12 December 2016]. Available from: http://www.sveff.se/files/2015/04/CEPE-guidance-on-labelling-with-biocidesskin-sensitizers-final-28-Oct-14.pdf [Internet].
5 Burnett CL, Bergfeld WF, Belsito DV, et al. Final report of the safety assessment of methylisothiazolinone. Int. J. Toxicol. 2010;29:187S-213S.   DOI
6 Krzywkowski K, Tonning K, Schwensen JF, Johansen JD. Survey and exposure assessment of methylisothiazolinone in consumer products. The Danish Environmental Protection Agency; 2015. p. 18-71.
7 Cuesta L, Silvestre JF, Toledo F, Ballester I, Betlloch I. Not detected by the baseline series of the Spanish group. Contact Dermatitis 2010;62:250-251.   DOI
8 Gonzalez-Munoz P, Conde-Salazar L, Vano-Galvan S. Allergic contact dermatitis caused by cosmetic products. Actas Dermo-Sifiliograficas (English edition) 2014;105:822-832.   DOI
9 Schwensen JF, Menne T, Andersen KE, Sommerlund M, Johansen JD. Occupations at risk of developing contact allergy to isothiazolinones in Danish contact dermatitis patients: Results from a Danish multicentre study (2009-2012). Contact Dermatitis 2014;71:295-302.   DOI
10 Rafoth A, Gabriel S, Sacher F, Brauch HJ. Analysis of isothiazolinones in environmental waters by gas chromatography-mass spectrometry. J. Chromatogr. A. 2007;1164:74-81.   DOI
11 Bester K, Lamani X. Determination of biocides as well as some biocide metabolites from facade run-off waters by solid phase extraction and high performance liquid chromatographic separation and tandem mass spectrometry detection. J. Chromatogr. A. 2010;1217:5204-5214.   DOI
12 Alvarez-Rivera G, Dagnac T, Lores M, et al. Determination of isothiazolinone preservatives in cosmetics and household products by matrix solid-phase dispersion followed by high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. A. 2012;1270:41-50.   DOI
13 Speksnijder P, van Ravestijn J, de Voogt P. Trace analysis of isothiazolinones in water samples by large-volume direct injection liquid chromatography tandem mass spectrometry. J. Chromatogr. A. 2010;1217:5184-5189.   DOI
14 Kahrilas GA, Blotevogel J, Stewart PS, Borch T. Biocides in hydraulic fracturing fluids: A critical review of their usage, mobility, degradation, and toxicity. Environ. Sci. Technol. 2015;49:16-32.   DOI
15 Basketter DA, Rodford R, Kimber I, Smith I, Wahlberg JE. Skin sensitization risk assessment: A comparative evaluation of 3 isothiazolinone biocides. Contact Dermatitis 1999;40:150-154.   DOI
16 Boyapati A, Tam M, Tate B, Lee A, Palmer A, Nixon R. Allergic contact dermatitis to methylisothiazolinone: exposure from baby wipes causing hand dermatitis. Australas. J. Dermatol. 2013;54:264-267.   DOI
17 Schettgen T, Kraus T. Urinary excretion kinetics of the metabolite N-methylmalonamic acid (NMMA) after oral dosage of chloromethylisothiazolinone and methylisothiazolinone in human volunteers. Arch. Toxicol. 2017;91:3835-3841.   DOI
18 Fewings J, Menne T. An update of the risk assessment for methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) with focus on rinse-off products. Contact Dermatitis 1999;41:1-13.   DOI
19 Cincinnati O. NEPIS Document display [Internet]. Available from: http://www.nepis.epa.gov/Exe/ZyNET.exe (accessed November 15, 2015).
20 Schettgen T, Bertram J, Kraus T. Quantification of N-methylmalonamic acid in urine as metabolite of the biocides methylisothiazolinone and chloromethylisothiazolinone using gas chromatography-tandem mass spectrometry. J. Chromatogr. B. 2017;1044-1045:185-193.   DOI
21 Chen ZF, Ying GG, Lai HJ, et al. Determination of biocides in different environmental matrices by use of ultra-high-performance liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 2012;404:3175-3188.   DOI
22 Park DU, Friesen MC, Roh HS, et al. Estimating retrospective exposure of household humidifier disinfectants. Indoor Air. 2015;25:631-640.   DOI
23 c2015 [cited 21 November 2015]. Available from: http://www.kcma.or.kr/chemicals/chemicalss1_1.asp [Internet].
24 c2015 [cited 21 November 2015]. Available from: http://www.kats.go.kr/content.do?cmsid=239&cid=10961&mode=view [Internet].
25 Singer H, Jaus S, Hanke I, Luck A, Hollender J, Alder AC. Determination of biocides and pesticides by on-line solid phase extraction coupled with mass spectrometry and their behaviour in wastewater and surface water. Environ. Pollut. 2010;158:3054-3064.   DOI
26 Lundov MD, Kolarik B, Bossi R, Gunnarsen L, Johansen JD. Emission of isothiazolinones from water-based paints. Environ. Sci. Technol. 2014;48:6989-6994.   DOI
27 Frauen M, Steinhart H, Rapp C, Hintze U. Rapid quantification of iodopropynyl butylcarbamate as the preservative in cosmetic formulations using high-performance liquid chromatography-electrospray mass spectrometry. J. Pharmaceut. Biomed. 2001;25:965-970.   DOI
28 Lin QB, Wang TJ, Song H, Li B. Analysis of isothiazolinone biocides in paper for food packaging by ultra-high-performance liquid chromatography-tandem mass spectrometry. Food. Addit. Contam. Part A. 2010;27:1775-1781.   DOI
29 c2015 [cited 21 November 2015]. Available from: http://www.pressian.com/news/article.html?no=5857 [Internet].