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http://dx.doi.org/10.1016/j.jiec.2013.11.025

Improvement single-wall carbon nanotubes (SWCNTs) based on functionalizing with monomers 2-hydroxyethylmethacryate (HEMA) and N-vinylpyrrolidone (NVP) for pharmaceutical applications as cancer therapy  

Abbaszadeh, Fatemeh (Department of Chemistry, Shahre Qods Branch, Islamic Azad University)
Moradi, Omid (Department of Chemistry, Shahre Qods Branch, Islamic Azad University)
Norouzi, Mehdi (Department of Virology, School of Public Health, Tehran University of Medical Sciences)
Sabzevari, Omid (Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences)
Publication Information
Journal of Industrial and Engineering Chemistry / v.20, no.5, 2014 , pp. 2895-2900 More about this Journal
Abstract
The functionalized carbon nanotubes play significant roles in the fields such as preparation of composite materials and biological technologies. This paper explains the covalent functionalization of single-wall carbon nanotubes (SWCNTs) with biomedical important monomers, 2-hydroxyethylmethacryate (HEMA) and N-vinylpyrrolidone (NVP) by chemical grafting of HEMA and PVP monomers via free radical polymerization. To get carboxylic acid functionalized SWCNTs, first the nanotubes were oxidized with a mixture of nitric acid and sulfuric acid (1:3). Then, the binding of HEMA and NVP onto the surface of SWCNTs was performed by chemical functionalization of HEMA, NVP with acid chloride-bound carbon nanotube by esterification reaction. These results were confirmed by FT-IR and SEM. The cell culture experiments conducted for pharmaceutical applications were used as cancer therapy.
Keywords
SWCNTs; HEMA; NVP; AIBN; Functionalization; Drug delivery; Cell culture; Hydrogels; Cell culture;
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