Antioxidant and Immunoenhancement Activities of Ginger (Zingiber officinale Roscoe) Extracts and Compounds in In Vitro and In Vivo Mouse and Human System |
Rungkat, F-Zakaria
(Department of Food Technology and Human Nutrition, Bogor Agricultural University, Indonesia)
Nurahman (Nutrition School, Semarang, Indonesia) E Prangdimurt (Department of Food Technology and Human Nutrition, Bogor Agricultural University, Indonesia) Tejasari (Faculty of Agricultural Technology, University of Jember) |
1 | Suekawa MA, Ishige A, Yuasa K, Sudo K, Aburada M,Hosoya E. 1984. Pharmacological studies on ginger I. Phar-macological actions of pungent constituents, (6)-gingero1and (6)-shogaol. J Pharmacobiodyn 7: 836-848 DOI |
2 | Hikino H, Kiso Y, Kato N, Hamada Y, Shioiri T, AiyamaR, Itokawa H, Kiuchi F, Sankawa U. 1985. Antihepatotoxic actions of gingerols and diarylheptanoids. J Ethnopharmacol14: 31-39 DOI ScienceOn |
3 | Nakatani N. 1997. Natural antioxidants from spices, In Phe-nolic Compounds in Food and Their Effects on health II.Huang M, Ho C, Lee CY, eds. Am Chem Soc., Washington DC |
4 | Zakaria-RF, Darsana L, Wijaya H. 1996. Immunity enhance-ment and cell protection activity of ginger buds and fresh ginger on mouse spleen lymphocytes. Paper presented at theSymp Non-Nutritive Health Factors for Future Foods. Ko-rean Soc Food Sci & Technol, Korea |
5 | Zakaria FR, Belleville F, Nabet P, Linden G. 1992. Aller genicity of bovine casein I. Specific lymphocyte proli-feration and histamine accumulation in the mastocyte asresults of casein feeding in mice. Food Agric Immunol 4:41-51 DOI ScienceOn |
6 | Zakaria FR, Wiguna Y, Hartoyo A. 1999. Consumption ofginger (Zingiber officinale Roscoe) drink increased natural killer cell activity in students from Ulil Alkaab in Bogor.Food Technol Industry Bull 9: 23-29 |
7 | Conti M, Morand PC, Levillain P, Lemonnier A. 1991. Im-proved fluorornetric determination of malonaldehyde. J ClinChem 37: 1273-1275 |
8 | Clausen J. 1995. An in vitro system for evaluation of oxi-dative stress and effects of antioxidants. Abstract presentedat the International Symposium on Natural Antioxidants.Peking, China |
9 | Murosaki S, Muroyama K, Yamamoto Y, Kusaka H, LiuT, Yoshika Y. 1999. Immunopotentiating activity of nigero-oligosaccharides for the T helper l-like immune response in mice. Biosci Biotechol Biochem 63: 373-378 DOI ScienceOn |
10 | Ross GD, Vetvicka V. 1993. CR3 (CDllb, CD18): a phag-ocyte and NK cell membrane receptor with multiple ligand specificity and functions. Clin Exp Immunol 92: 181-184 DOI ScienceOn |
11 | Singletary K. 2000. Diet, natural products and cancer chemo-prevention. J Nutr 130: 465S-466S |
12 | Meydani SN, Wu D, Santos MS, Hayek MG. 1995. Anti-oxidants and immune response in aged persons: Overview of present evidence. Am J Clin Nutr 62: 146S-147S |
13 | Bus JS, Cagen SZ, Olgaard M, Gibson JE. 1976. A mech-anism of paraquat toxicity in mice and rats. Toxicol ApplPharmacol 35: 501-513 |
14 | Wikandari P. 1995. Development of extraction methods forthe analysis gingerol in fresh and processed ginger. Thesis.Food Science Graduate School, Bogor Agricultural Univer-sity, Indonesia |
15 | Tang W, Eisenbrand G. 1992. Chinese Drugs of PlantOrigin: Chemistry, Pharmacology and Use in Traditionaland Modern Medicine. Springer-Verlag, New York. p 20 |
16 | McCaleb R. 1991. Herbal Gram. Res Rev 25: 45-56 |
17 | Wasowicz W, Neve J, Peretz A. 1993. Optimized steps in fluorometric determination of thiobarbituraric acid-reactive substance in serum: importance of extraction pH and in-fluence of sample preservation and storage. Clin Chem 39:2522-2526 |
18 | Keys JD. 1981. Chinese Herbs: Their Botany, Chemistry and Pharmacodynamics. Charles E. Tuttle Co, Tokyo. p 65 |
19 | Nurahman, Zakaria FR, Sanjaya, Sayuthi D. 1999. The effect of ginger consumption on the protective effect of lym-phocytes from oxidative stress in students from Ulil Alkaab,Kedung Badak, Bogor. In Proceeding of National Seminaron Food Technology. Zakaria-Rungkat F, Suhartono M,Astawan M, eds. PATPI & MENPANGHOR, Jakarta |
20 | Aruoma OI. 1997. Assessment of potential prooxidant and antioxidant actions. Am Oil Chemist Soc 73: 1617-1625 |
21 | Zakaria-Rungkat F, Djaelani M, Setiana, Rumondang E,Nurrochma. 2000. Retinol accumulation in rat livers as ameasure of carotenoid bioavailability of green vegetablesand carbohydrate containing foods. J Food Comp Anal 13:297-310 DOI ScienceOn |
22 | Halliwell B, Gutteridge JMC, Cross CE. 1992. Free rad-icals, antioxidant and human diseases: where are we now?J Lab Clin Med 119: 508-620 |
23 | Hwang JK, Lim TS, Na K, Yun JM, Choi EM. 2002. Abstract no 13 presented at Intl Symp on Antioxidants inNutr & Therapy: Mechanism in Physiology-Pathology-Pharmacology. Kuta, Bali, Indonesia |
24 | Kobayashi KK, Yoshida A, 1986. Effect dietary ascorbic acid and vitamin E on metabolic changes in rats and guinea pigs exposed to PCB. J Nutr 116: 98-106 |
25 | Zakaria FR. 1996. Synthesis of radical and electrophile compounds in and by food compounds, In Radical Compounds and Food System: Biomolecular reaction, Ejffects on Healthand Prevention. Zakaria FR, Dewanti R, Yasni S, eds. CFNS,IPB, Bogor, Indonesia, p 31 |
26 | Craig WJ. 1999. Health promoting properties of common herbs. Am J Clin Nutr 70: 491S-499S |
27 | Fritz KL, Nelson TL, Ruiz-Velasco V, Mercurio SD. 1994.Acute intramuscular injection of oils or oleic acid component protects mice against paraquat lethality. J Nutr 194: 425-429 |
28 | WCRF & AICR. 1997. Food, Nutrition and the Preventionof Cancer: a Global Perspective. WCRF & AICR, London |
29 | Murakami A, Ohigashi H, Koshimizu K. 1999. Chemopre-vention: insights into biological mechanisms and promising food factors. Food Rev Int 15: 335-395 DOI |
30 | Zakaria-Rungkat F, Irawan Bus, Pramudya SM, Sanjaya.2000. Fruits and vegetables as the sources of vitamin C danE intervention increased the immune system in industryworkers in Bogor. Food Technol Industry Bull 11 (2): 21-27 |
31 | Tejasari, Zakaria-R F. 2000. Functional properties of ginger:fractions 1 dan 2 of ginger (Zingiber officinale Roscoe) bio-active oleoresin compounds decreased lymphocyte mem-brane lipid peroxidation in vitro, In Proceeding of Food In-dustry Nat Seminar. Budiyanto S, Muchtadi M, eds. PATPI,Surabaya. Vol II |
32 | Zakaria F, Susanto H, Hartoyo H. 2000. The effects of ginger(Zingiber officinale Roscoe) consumption on malonalde hideand vitamin E levels in students from Ulil Alkaab Kedung Badak Bogor. Food Technol Industry Bull 10: 36-40 |
33 | Santell RC, Kieu N, Helferich WG. 2000. Genistein inhibits growth of estrogen-independent human breast cancer cellsin culture but not in athymic mice. J Nutr 130: 1665-1669 |
34 | Zakaria-Rungkat F, Septiana AT, Sulistiyani. 2001. Ginger(Zingiber officinale Roescoe) extracts increase human LDLresistance to oxidation and prevent cholesterol accumulation in macrophage. Abstract presented at The Second Intl Sympon Natural Antioxidant: Molecular Mechanism and HealthAffects, Beijing, China |
35 | Yellayi S, Naaz A, Szewczykowski MA, Sato S, Woods JA,Chang J, la Segre M, Allred CD, Helferich WG, Cooke PS.2002. The phytoestrogen genistein induces thymic and im-mune changes: A human health concern? Proc Natl AcadSci USA 99 (Issue 11): 7616-7621 DOI ScienceOn |
36 | Furhman B, Rosenblat M, Hayek T, Colerman R, Aviram M. 2000. Ginger extract consumption reduces plasma chol-esterol, inhibits LDL oxidation and attenuates developmentof atherosclerosis in atherosclerotic, apolipoprottein E-defi-cient mice. J Nutr 130: 1124-1131 |