[KSCI] Korea Science Citation Index Service

A Bio-Inspired Cell-Microsystem to Manipulate and Detect Living Cells

Lim, Jung-Min (School of Electrical and Computer Engineering, Seoul National University)
Byun, Sang-Won (School of Electrical and Computer Engineering, Seoul National University)
Park, Tai-Hyun (School of Chemical Engineering, Seoul National University)
Seo, Jong-Mo (Department of Ophthalmology, Seoul National University)
Yoo, Young-Suk (Department of Ophthalmology, Seoul National University)
Hum Chung (Department of Ophthalmology, Seoul National University)
Dong-il (School of Electrical and Computer Engineering, Seoul National University)

Publication Information

KIEE International Transactions on Electrophysics and Applications / v.4C, no.4, 2004 , pp. 160-164 More about this Journal

Abstract

In this study, we demonstrate for the first time a bio-inspired Cell-Microsystem to manipulate and detect living cells. Cultured retinal pigment epithelial cell line (ARPE-19) was directed to grow in a pre-defined Cell-Microsystem. The three-dimensional micropillars of 5 ${\mu}{\textrm}{m}$ in height and diameter of the Cell-Microsystem were fabricated. Inhibited DNA synthesis and transformed cell morphology were observed throughout the culture period. The demonstration of manipulating and detecting living cells by the surface topography is a new approach, and it will be very useful for the future design of cell-based biosensors and bioactuators.

Keywords

Cell Morphology; DNA Synthesis; Micropillar; Microsystem; Retinal Pigment Epithelial Cells;

Citations & Related Records

Reference

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