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http://dx.doi.org/10.5713/ajas.16.0562

Genome scan linkage analysis identifies a major quantitative trait loci for fatty acid composition in longissimus dorsi muscle in an F2 intercross between Landrace and Korean native pigs  

Park, Hee-Bok (Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration)
Han, Sang-Hyun (Educational Science Research Institute, Jeju National University)
Yoo, Chae-Kyoung (Institute of Agriculture and Life Sciences, Gyeongsang National University)
Lee, Jae-Bong (Korea Zoonosis Research Institute, Chonbuk National University)
Kim, Ji-Hyang (Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration)
Baek, Kwang-Soo (Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration)
Son, Jun-Kyu (Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration)
Shin, Sang-Min (Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration)
Lim, Hyun-Tae (Institute of Agriculture and Life Sciences, Gyeongsang National University)
Cho, In-Cheol (Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.30, no.8, 2017 , pp. 1061-1065 More about this Journal
Abstract
Objective: This study was conducted to locate quantitative trait loci (QTL) influencing fatty acid (FA) composition in a large $F_2$ intercross between Landrace and Korean native pigs. Methods: Eighteen FA composition traits were measured in more than 960 $F_2$ progeny. All experimental animals were genotyped with 165 microsatellite markers located throughout the pig autosomes. Results: We detected 112 QTLs for the FA composition; Forty seven QTLs reached the genome-wide significant threshold. In particular, we identified a cluster of highly significant QTLs for FA composition on SSC12. QTL for polyunsaturated fatty acid on pig chromosome 12 (F-value = 97.2 under additive and dominance model, nominal p-value $3.6{\times}10^{-39}$) accounted for 16.9% of phenotypic variance. In addition, four more QTLs for C18:1, C18:2, C20:4, and monounsaturated fatty acids on the similar position explained more than 10% of phenotypic variance. Conclusion: Our findings of a major QTL for FA composition presented here could provide helpful information to locate causative variants to improve meat quality traits in pigs.
Keywords
Fatty Acid; Quantitative Trait Locus; Genome-wide Linkage Analysis; Landrace; Korean Native Pigs;
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