[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5713/ajas.16.0824

Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens

Sikandar, Arbab (Sub-campus, Jhang, University of Veterinary and Animal Sciences)
Zaneb, Hafsa (University of Veterinary and Animal Sciences)
Younus, Muhammad (Sub-campus, Jhang, University of Veterinary and Animal Sciences)
Masood, Saima (University of Veterinary and Animal Sciences)
Aslam, Asim (University of Veterinary and Animal Sciences)
Khattak, Farina (Monogastric Science Research Centre, Scotland's Rural College)
Ashraf, Saima (University of Veterinary and Animal Sciences)
Yousaf, Muhammad Shahbaz (University of Veterinary and Animal Sciences)
Rehman, Habib (University of Veterinary and Animal Sciences)

Publication Information

Asian-Australasian Journal of Animal Sciences / v.30, no.5, 2017 , pp. 690-699 More about this Journal

Abstract

Objective: This study aimed to examine the effect of sodium butyrate (SB) on growth performance, immune status, organs weights, and microarchitecture of lymphoid organs and small intestine. Methods: A total of 120, 1-d-old broiler chicks were distributed into the following four treatment groups: corn-soy based basal diet (BD) without supplement (control), or the same BD supplemented with 0.1 g/kg zinc bacitracin (ZnB), 0.5 g/kg SB (SB-0.5), or 1.0 g/kg SB (SB-1), respectively. Six birds/group were killed on d-21 and d-35, and samples were collected. Results: Cell-mediated immune response at 48 h post-Phytohemagglutinin-P injection, and antibody titer against Newcastle disease vaccine and sheep red blood cells on d-35 was noted higher (p<0.05) in SB-1 compared to ZnB and control. Lower (p<0.05) feed conversion ratio (FCR) was attained by the supplemented groups. Thymus and spleen weighed more (p<0.05) in SB-1, and bursa registered more (p<0.05) weight in both SB groups compared to control. On d-21, areas of thymus medulla and spleen germinal centers were noted higher (p<0.05) in SB-1 group. The villus height and villus surface area increased (p<0.05) in duodenum and jejunum in both SB groups on d-21, and in SB-1 on d-35, respectively compared to ZnB and control. On d-21, number of goblet cells containing mucins of acidic nature increased (p<0.05) in all the segments of small intestines in SB-1 group compared to control, and on d-35 in ileum compared to other groups. Conclusion: In conclusion, SB improved growth performance and immunity as well as modulated morphology of lymphoid organs and gut mucosa in broiler chickens.

Keywords

Organic Acid; Poultry; Antibiotic Growth Promoter; Mucosa; Intraepithelial Lymphocytes; Goblet Cells;

Citations & Related Records

Times Cited By KSCI : 1 (Citation Analysis)

Reference
Cited By KSCI

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