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http://dx.doi.org/10.5713/ajas.15.0980

Identification of loci affecting teat number by genome-wide association studies on three pig populations  

Tang, Jianhong (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Zhang, Zhiyan (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Yang, Bin (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Guo, Yuanmei (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Ai, Huashui (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Long, Yi (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Su, Ying (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Cui, Leilei (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Zhou, Liyu (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Wang, Xiaopeng (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Zhang, Hui (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Wang, Chengbin (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Ren, Jun (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Huang, Lusheng (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Ding, Nengshui (State Key Laboratory for Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.30, no.1, 2017 , pp. 1-7 More about this Journal
Abstract
Objective: Three genome-wide association studies (GWAS) and a meta-analysis of GWAS were conducted to explore the genetic mechanisms underlying variation in pig teat number. Methods: We performed three GWAS and a meta-analysis for teat number on three pig populations, including a White Duroc${\times}$Erhualian $F_2$ resource population (n = 1,743), a Chinese Erhualian pig population (n = 320) and a Chinese Sutai pig population (n = 383). Results: We detected 24 single nucleotide polymorphisms (SNPs) that surpassed the genome-wide significant level on Sus Scrofa chromosomes (SSC) 1, 7, and 12 in the $F_2$ resource population, corresponding to four loci for pig teat number. We highlighted vertnin (VRTN) and lysine demethylase 6B (KDM6B) as two interesting candidate genes at the loci on SSC7 and SSC12. No significant associated SNPs were identified in the meta-analysis of GWAS. Conclusion: The results verified the complex genetic architecture of pig teat number. The causative variants for teat number may be different in the three populations
Keywords
Genome-wide Association Study; Imputation; Meta-analysis; Pig; Teat Number;
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