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http://dx.doi.org/10.5713/ajas.15.0502

Relationship between Single Nucleotide Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Gene and Fatty Acid Composition in Korean Native Cattle  

Lee, Jea-young (Department of Statistics, Yeungnam University)
Ha, Jae-jung (Livestock Research institute)
Park, Yong-soo (Department of Equine Industry, Korea National College of Agriculture and Fisheries)
Yi, Jun-koo (Livestock Research institute)
Lee, Seunguk (Biotechnology Research Center, The University of Tokyo)
Mun, Seyoung (Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University)
Han, Kyudong (Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University)
Kim, J.-J. (School of Biotechnology, Yeungnam University)
Kim, Hyun-Ji (Department of Statistics, Yeungnam University)
Oh, Dong-yep (Livestock Research institute)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.29, no.2, 2016 , pp. 184-194 More about this Journal
Abstract
The peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$) gene plays an important role in the biosynthesis process controlled by a number of fatty acid transcription factors. This study investigates the relationships between 130 single-nucleotide polymorphisms (SNPs) in the $PPAR{\gamma}$ gene and the fatty acid composition of muscle fat in the commercial population of Korean native cattle. We identified 38 SNPs and verified relationships between 3 SNPs (g.1159-71208 A>G, g.42555-29812 G>A, and g.72362 G>T) and the fatty acid composition of commercial Korean native cattle (n = 513). Cattle with the AA genotype of g.1159-71208 A>G and the GG genotype of g.42555-29812 G>A and g.72362 G>T had higher levels of monounsaturated fatty acids and carcass traits (p<0.05). The results revealed that the 3 identified SNPs in the $PPAR{\gamma}$ gene affected fatty acid composition and carcass traits, suggesting that these 3 SNPs may improve the flavor and quality of beef in commercial Korean native cattle.
Keywords
Korean Native Cattle; $PPAR{\gamma}$; SNP; Fatty Acid Composition; Marbling Score;
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Times Cited By KSCI : 4  (Citation Analysis)
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1 Lee, M. A., O. M. Keane, B. C. Glass, T. R. Manley, N. G. Cullen, K. G. Dodds, A. F. McCulloch, C. A. Morris, M. Schreiber, J. Warren, A. Zadissa, T. Wilson, and J. C. McEwan. 2006. Establishment of a pipeline to analyse non-synonymous SNPs in Bos Taurus. BMC Genomics 7:298.   DOI
2 Lee, S. H., D. H. Yoon, S. H. Hwang, E. Y. Cheong, O. H. Kim, and C. S. Lee. 2004. Relationship between monounsaturated fatty acid composition and stearoyl-CoA desaturase mRNA level in Hanwoo liver and loin muscle. J. Anim. Sci. Technol. (Kor). 46:7-14.   DOI
3 Lee, S. H., Y. M. Cho, S. H. Lee, B. S Kim, N. K. Kim, Y. H Choy, K. H. Kim, D. Yoon, S .K Im, S. J Oh, and E. W. Park. 2008. Identification of marbling-related candidate genes in M. longissimus dorsi of high- and low marbled Hanwoo (Korean Native Cattle) steers. BMB Rep. 41:846-851.   DOI
4 Mandell, I. B., J. G. Buchanan-Smith, and C. P. Campbell. 1998. Effects of forage vs grain feeding on carcass characteristics, fatty acid composition, and beef quality in Limousin-cross steers when time on feed is controlled. J. Anim. Sci. 76: 2619-2630.   DOI
5 Mangelsdorf, D. J. and R. M. Evans. 1995. The RXR heterodimers and orphan receptors. Cell 83:841-850.   DOI
6 Melton, S. L., M. Amiri, G. W. Davis, and W. R. Backus. 1982. Flavor and chemical characteristics of ground beef from grass-, forage-grain- and grain-finished steers. J. Anim. Sci. 55:77-87.   DOI
7 Nagai, S., C. Shimizu, M. Umetsu, S. Taniguchi, M. Endo, H. Miyoshi, N. Yoshioka, M. Kubo, and T. Koike. 2004. Identification of a functional peroxisome proliferator-activated receptor responsive element within the murine perilipin gene. Endocrinology 145:2346-2356.   DOI
8 Narukami, T., S. Sasazaki, K. Oyama, T. Nogi, M. Taniguchi, and H. Mannen. 2011. Effect of DNA polymorphisms related to fatty acid composition in adipose tissue of Holstein cattle. Anim. Sci. J. 82:406-411.   DOI
9 Oh, D., Y. Lee, C. Lee, E. Chung, and J. Yeo. 2012. Association of bovine fatty acid composition with missense necleotide polymorphism in exon7 of peroxisome proliferator-activated receptor gamma gene. Anim. Genet. 43:474.
10 O'Keefe, P. W., G. H. Wellington, L. R. Mattick, and J. R. Stouffer. 1968. Composition of bovine muscle lipids at various carcass locations. J. Food Sci. 33:188-192.   DOI
11 Reidiger, N. D., R. A. Othman, M. Suh, and M. H. Moghadasian. 2009. A systemic review of the roles of n-3 fatty acids in health and disease. J. Am. Diet. Assoc. 109:668-679.   DOI
12 Rosen, E. D. and B. M. Spiegelman. 2001. PPAR gamma: a nuclear regulator of metabolism, differentiation, and cell growth. J. Biol. Chem. 276:37731-37734.   DOI
13 Schulman, I. G., G. Shao, and R. A. Heyman. 1998. Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor $\gamma$ ($PPAR\gamma$) heterodimers:intermolecular synergy requires only the $PPAR\gamma$ hormone-dependent activation function. Mol. Cell. Biol. 18:3483-3494.   DOI
14 Shanika, P. S., M. S. Maria, M. D. Arpad, N. J. Daniel, J. B. Matthew, and N. C. Ronald. 2009. Altering PPAR ligand selectivity impairs adipogenesis by thiazolidinediones but not hormonal inducers. Obesity 17:965-972.   DOI
15 Shin, S. C. 2006. The Development of DNA Markers Related to Carcass and Meat quality Traits in Korean Cattle. MS thesis, Sang Ji University, Wonju, Korea.
16 Spiegelman, B. M. 1998. PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 47:507-514.   DOI
17 Shin, S. C., M. J. Kang, and E. R. Chung. 2007. Identification of a novel SNP associated with meat quality in C/$EBP{\alpha}$ gene of Korean cattle. Asian Australas. J. Anim. Sci. 20:466-470.   DOI
18 Smith, S. B., C. A. Gill, D. K. Lunt, and M. A. Brooks. 2009. Regulation of fat and fatty acid composition in beef cattle. Asian Australas. J. Anim. Sci. 22:1225-1233.   DOI
19 Smith, S. B., A. Yang, T. W. Larsen, and R. K. Tume. 1998. Positional analysis of triacylglycerols from bovine adipose tissue lipids varying in degree of unsaturation. Lipids 33:197-207.   DOI
20 Tsuji, S., K. Itoh, S. Sasazaki, H. Mannen, K. Oyama, M. Shojo, and F. Mukai. 2004. An association study using AFLP markers and application to a beef cattle breeding population. Anim. Genet. 35:40-43.   DOI
21 Venables, W. N. and B. D. Ripley. 2002. Modern Applied Statistics with S. 4th Edition. Springer, New York, USA.
22 Vreeland, W. N., R. J. Meagher, and A. E. Barron. 2002. Multiplexed, high-throughput genotyping by single-base extension and end-labeled free-solution electrophoresis. Anal. Chem. 74:4328-4333.   DOI
23 Wood, J. D., R. I. Richardson, G. R. Nute, A. V. Fisher, M. M. Campo, E. Kasapidou, P. R. Sheard, and M. Enser. 2004. Effects of fatty acids on meat quality: A review. Meat Sci. 66: 21-32.   DOI
24 Yang, A., T. W. Larsen, S. B. Smith, and R. K. Tume. 1999. ${\Delta}9$-desaturase activity in bovine subcutaneous adipose tissue of different fatty acid composition. Lipids 34:971-978.   DOI
25 Falconer, D. S. and T. F. C. Mackay. 1996. Introduction to Quantitative Genetics, fourth ed. Longman, London, England.
26 Yu, C., K. Markan, K. A. Temple, D. Deplewski, M. J. Brady, and R. N. Cohen. 2005. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. J. Biol. Chem. 280:13600-13605.   DOI
27 Alexander, L. J., M. D. MacNeil, T. W. Geary, W. M. Snelling, D. C. Rule, and J. A. Scanga. 2007. Quantitative trait loci with additive effects on palatability and fatty acid composition of meat in a Wagyu-Limousin $F_2$ population. Anim. Genet. 38: 506-513.   DOI
28 Christine, Y., M. Kathleen, A. T. Karla, D. Dianne, J. B. Matthew, and N. C. Ronald. 2005. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor ${\gamma}$ transcriptional activity and repress 3T3-L1 adipogenesis. J. Biol. Chem. 280:13600-13605.   DOI
29 Chung, K. Y., D. K. Lunt, C. B. Choi, S. H. Chae, R. D. Rhoades, T. H. Adams, B. Booren, and S. B. Smith. 2006. Lipid characteristics of subcutaneous adipose tissue and M. longissimus thoracis of Angus and Wagyu steers fed to US and Japanese endpoints. Meat Sci. 73:432-441.   DOI
30 Eberle, M. A., M. J. Rieder, L. Kruglyak, and D. A. Nickerson. 2006. Allele frequency matching between snps reveals an excess of linkage disequilibrium in genic regions of the human genome. PLoS Genet. 2:e142.   DOI
31 Fan, Y. Y., L. S. Zan, C. Z. Fu, W. Q. Tian, H. B. Wang, Y. Y. Liu, and Y. P. Xin. 2011. Three novel SNPs in the coding region of $PPAR\gamma$ gene and their associations with meat quality traits in cattle. Mol. Biol. Rep. 38:131-137.   DOI
32 Folch, J., M. Lee, and G. H. S. Stanley. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226:487-509.
33 Guan, H. P., T. Ishizuka, P. C. Chui, M. Lehrke, and M. A. Lazar. 2005. Corepressors selectively control the transcriptional activity of PPAR gamma in adipocytes. Genes Dev. 19: 453-461.   DOI
34 Hoashi, S., N. Ashida, H. Ohsaki, T. Utsugi, S. Sasazaki, M. Taniguchi, K. Oyama, F. Mukai, and H. Mannen. 2007. Genotype of bovine sterol regulatory element binding protein-1 (SREBP-1) is associated with fatty acid composition in Japanese Black cattle. Mamm. Genome 18:880-886.   DOI
35 Kersten, S., S. Mandard, P. Escher, F. J. Gonzalez, S. Tafuri, B. Desvergne, and W. Wahli. 2000. The peroxisome proliferator-activated receptor ${\alpha}$ regulates amino acid metabolism. FASEB J. 15:1971-1978.
36 Hua, L., J. Wang, F. Chen, S. Hu, and H. Chen. 2011. The peroxisome proliferators-ativated receptor gamma (PPARG) gene polymorphisms and associations with body measurements of cattle. Afr. J. Biotechnol. 10:2785-2790.   DOI
37 Iwaki, M., M. Matsuda, N. Maeda, T. Funahashi, Y. Matsuzawa, M. Makishima, and I. Shimomura. 2003. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52:1655-1663.   DOI
38 Jeoung, Y. H., S. M. Lee, H. Y. Pack, D. H. Yoon, J. G. Choi, S. J. Moon, and M. J. Kang. 2004. Molecular Cloning mRNA Expression of the Bovine Peroxisome Proliperator Recepter Gamma ($PPAR\gamma$). J. Anim. Sci. Technol. (Kor). 46:23-30.   DOI
39 Kim, J. H., C. H. Kim, and Y. D. Ko. 2002. Influence of dietary addition of dried wormwood (Artemisia sp.) of the performance and carcass characteristics of Hanwoo steers and the nutrient digestibility of sheep. Asian Australas. J. Anim. Sci. 15:390-395.   DOI
40 Kodera, Y., K. Takeyama, A. Murayama, M. Suzawa, Y. Masuhiro, and S Kato. 2000. Ligand type-specific interactions of peroxisome proliferatoractivated receptor ${\gamma}$ with transcriptional coactivators. J. Biol. Chem. 275:33201-33204.   DOI
41 Laborde, F. L., I. B. Mandell, J. J. Tosh, J. W. Wilton, and J. G. Buchanan-Smith. 2001. Breed effects on growth performance, carcass characteristics, fatty acid composition, and palatability attributes in finishing steers. J. Anim. Sci. 79:355-365.   DOI