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http://dx.doi.org/10.5713/ajas.2013.13592

The Expression of Leptin, Estrogen Receptors, and Vitellogenin mRNAs in Migrating Female Chum Salmon, Oncorhynchus keta: The Effects of Hypo-osmotic Environmental Changes  

Choi, Young Jae (Division of Marine Environment and BioScience, Korea Maritime and Ocean University)
Kim, Na Na (Division of Marine Environment and BioScience, Korea Maritime and Ocean University)
Shin, Hyun Suk (Division of Marine Environment and BioScience, Korea Maritime and Ocean University)
Choi, Cheol Young (Division of Marine Environment and BioScience, Korea Maritime and Ocean University)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.27, no.4, 2014 , pp. 479-487 More about this Journal
Abstract
Leptin plays an important role in energy homeostasis and reproductive function in fish, especially in reproduction. Migrating fish, such as salmonoids, are affected by external environmental factors, and salinity changes are a particularly important influence on spawning migrations. The aim of this study was to test whether changes in salinity affect the expression of leptin, estrogen receptors (ERs), and vitellogenin (VTG) in chum salmon (Oncorhynchus keta). The expression and activity of leptin, the expression of ERs and VTG, and the levels of estradiol-$17{\beta}$ and cortisol increased after the fish were transferred to FW, demonstrating that changes in salinity stimulate the HPG axis in migrating female chum salmon. These findings reveal details about the role of elevated leptin levels and sex steroid hormones in stimulating sexual maturation and reproduction in response to salinity changes in chum salmon.
Keywords
Chum Salmon; Estrogen Receptors; Leptin; Maturation; Salinity Change; Vitellogenin;
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1 Ishibashi, O. and H. Kawashima. 2001. Cloning and characterization of the functional promoter of mouse estrogen receptor beta gene. Biochim. Biophys. Acta 1519:223-229.   DOI   ScienceOn
2 Makino, K., T. A. Onuma, T. Kitahashi, H. Ando, M. Ban, and A. Urano. 2007. Expression of hormone genes and osmoregulation in homing chum salmon: a mini review. Gen. Comp. Endocrinol. 152:304-309.   DOI   ScienceOn
3 Kim, N. N., H. S. Shin, Y. J. Choi, Y. Yamamoto, K. Fukaya, H. Ueda, and C. Y. Choi. 2013. Effect of hypo-osmotic environmental changes on the expression of gonadotropin-releasing hormone, its receptor, and gonadotropin hormone subunit mRNA in adult chum salmon (Oncorhynchus keta). Mar. Freshw. Behav. Physiol. 45:397-410.   DOI
4 Laurent, P. and S. F. Perry. 1990. The effects of cortisol on gill chloride cell morphology and ionic uptake on the freshwater trout, Salmo gairdneri. Cell Tissue Res. 259:429-442.   DOI
5 Maffei, M., J. Halaas, E. Ravussin, R. E. Pratley, G. H. Lee, Y. Zhang, H. Fei, S. Kim, R. Lallone, and S. Ranganathan. 1995. Leptin levels in human and rodent: measurement of plasma leptin and obRNA in obese and weight-reduced subjects. Nat. Med. 1: 1155-1161.   DOI   ScienceOn
6 Meucci, V. and A. Arukwe. 2006. Transcriptional modulation of brain and hepatic estrogen receptor and P450-arom isotypes in juvenile Atlantic salmon (Salmo salar) after waterborne exposure to the xenoestrogen, 4-nonylphenol. Aquat. Toxicol. 77:167-177.   DOI   ScienceOn
7 Nagasaka, R., N. Okamoto, and H. Ushio. 2006. Increased leptin may be involved in the short life span of ayu (Plecoglossus altivelis). J. Experimen. Zool. Part A. 305:507-512.
8 Nagahama, Y., M. Yoshikuni, M. Yamashita, T. Tokumoto, and Y. Katsu. 1995. Regulation of oocyte growth and maturation in fish. Curr. Top. Dev. Biol. 30: 103-145.   DOI
9 Onuma, T. A., M. Higa, H. Ando, M. Ban, and A. Urano. 2005. Elevation of gene expression for salmon gonadotropin-releasing hormone in discrete brain loci of prespawning chum salmon during upstream migration. J. Neurobiol. 63:126-145.   DOI   ScienceOn
10 Ronnestad, I., T. O. Nilsen, K. Murashita, A. R. Angotzi, A. G. Gamst Moen, S. O. Stefansson, P. Kling, B. Thrandur Bjornsson, and T. Kurokawa. 2013. Leptin and leptin receptor genes in Atlantic salmon: cloning, phylogeny, tissue distribution and expression correlated to long-term feeding status. Gen. Comp. Endocrinol. 168:55-70.
11 Pankhurst, N. W. and P. M. Thomas. 1998. Maintenance at elevated temperature delays the steroidogenic and ovulatory responsiveness of rainbow trout Oncorhynchus mykiss to luteinizing hormone releasing hormone analogue. Aquaculture 166:163-177.   DOI   ScienceOn
12 Rayner, D. V. and P. Trayhurn. 2001. Regulation of leptin production: sympathetic nervous system interactions. J. Mol. Med. 79:8-20.   DOI   ScienceOn
13 Ryffel, G. U. 1978. Synthesis of vitellogenin, an attractive model for investigating hormone-induced gene activation. Mol. Cell. Endocrinol. 12:237-246.   DOI   ScienceOn
14 Sabo-Attwood, T., K. J. Kroll, and N. D. Denslow. 2004. Differential expression of largemouth bass (Micropterus salmoides) estrogen receptor isotypes alpha, beta, and gamma by estradiol. Mol. Cell. Endocrinol. 218:107-118.   DOI   ScienceOn
15 Sahu, A. 2004. Leptin signalling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front. Neuroendocrinol. 24:225-253.
16 Tyler, C. R. and J. P. Sumpter. 1996. Oocyte growth and development in teleosts. Rev. Fish Biol. Fish. 6:287-318.   DOI
17 Slater, C. H., C. B. Schreck, and D. F. Amend. 1995. GnRHa injection accelerates final maturation and ovulation/ spermiation of sockeye salmon (Oncorhynchus nerka) in both fresh and salt water. Aquaculture 130:279-285.   DOI   ScienceOn
18 Swanson, P., J. T. Dickey, and B. Campbell. 2003. Biochemistry and physiology of fish gonadotropins. Fish Physiol. Biochem. 28: 53-59.   DOI   ScienceOn
19 Trombley, S. and N. Schmitz. 2013. Leptin in fish: possible role in sexual maturation in male Atlantic salmon. Fish Physiol. Biochem. 39:103-106.   DOI   ScienceOn
20 Urano, A., H. Ando, and H. Ueda. 1999. Molecular neuroendocrine basis of spawning migration in salmon. In: Recent Progress in Molecular and Comparative Endocrinology. (Ed. H. B. Kwon, J. M. P. Joss, and S. Ishi). Horm. Res. Center, Kwangju, Korea. pp. 46-56.
21 Volkoff, H., L. F. Canosa, S. Unniappan, J. M. Cerda-Reverter, N. J. Bernier, S. P. Kelly, and R. E. Peter. 2005. Neuropeptides and the control of food intake in fish. Gen. Comp. Endocrinol. 142:3-19.   DOI   ScienceOn
22 Weil, C., P. Y. Le Bail, N. Sabin, and F. Le Gac. 2003. In vitro action of leptin on FSH and LH production in rainbow trout (Onchorynchus mykiss) at different stages of the sexual cycle. Gen. Comp. Endocrinol. 130:2-12.   DOI   ScienceOn
23 Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.   DOI   ScienceOn
24 Crossin, G. T., S. G. Hinch, A. P. Farrell, D. A. Higgs, A. G. Lotto, J. D. Oakes, and M. C. Healey. 2004. Energetics and morphology of sockeye salmon: effects of upriver migratory distance and elevation. J. Fish Biol. 65:788-810.   DOI   ScienceOn
25 Zhou, B., S. P. Kelly, and C. M. Wood. 2004. Response of developing cultured freshwater gill epithelia to gradual apical media dilution and hormone supplementation. J. Exp. Zool. A Comp. Exp. Biol. 301:867-881.
26 Copeland, D. L., R. J. Duff, Q. Liu, J. Prokop, and R. L. Londraville. 2011. Leptin in teleost fishes: an argument for comparative study. Front. Physiol. 2:26.
27 Bowman, C. J., K. J. Kroll, T. G. Gross, and N. D. Denslow. 2002. Estradiol-induced gene expression in largemouth bass (Micropterus salmoides). Mol. Cell. Endocrinol. 196:67-77.   DOI   ScienceOn
28 Cella, F., G. Giordano, and R. Cordera. 2000. Serum leptin concentrations during the menstrual cycle in normal-weight women: effects of an oral triphasic estrogen-progestin medication. Eur. J. Endocrinol. 142:174-178.   DOI
29 Cooperman, M. C., S. G. Hinch, G. T. Crossin, S. J. Cooke, D. A. Patterson, I. Olsson, A. Lotto, D. Welch, J. M. Shrimpton, A. P. Farrell, and G. van der Kraak. 2010. Effects of experimental manipulations of salinity and maturation status on the physiological condition and mortality of homing adult sockeye salmon held in a laboratory. Physiol. Biochem. Zool. 83:459-472.   DOI   ScienceOn
30 Davis, L. K., N. Visitacion, L. Riley, N. Hiramatsu, C. Sullivan, T. Hirano, and E. Gordon Grau. 2009. Effects of o,p'-DDE, heptachlor, and $17{\beta}$-estradiol on vitellogenin gene expression and the growth hormone/insulin-like growth factor-I axis in the tilapia, Oreochromis mossambicus. Comp. Biochem. Physiol C. 149: 507-514.
31 De Pedro, N. and B. T. Bjornsson. 2001. Regulation of food intake by neuropeptides and hormones. In: Food intake in fish (Ed. D. Houlihan, T. Boujard, and M. Jobling). Blackwell Science, Oxford, UK. pp. 269-296.
32 Hendry, A. P. and O. K. Berg. 1999. Secondary sexual characteristics, energy use, senescence, and the cost of reproduction in sockeye salmon. Can. J. Zool. 77:1663-1675.   DOI
33 Denver, R. J., R. M. Bonnett, and G. C. Boorse. 2011. Evolution of leptin structure and function. Neuroendocrinology 94:21-38.   DOI   ScienceOn
34 Froiland, E., K. Murashita, E. H. Jorgensen, and T. Kurokawa. 2010. Leptin and ghrelin in anadromous Arctic charr: cloning and change in expressions during a seasonal feeding cycle. Gen. Comp. Endocrinol. 165:136-143.   DOI   ScienceOn
35 Hirano, T., T. Ogasawara, J. P. Bolton, N. L. Collie, S. Hasegawa, and M. Iwata. 1987. Osmoregulatory role of prolactin in lower vertebrates. In: Comparative Physiology and Environmental Adaptations. vol. 1. (Ed. R. Kirsch, and B. Lahlou). Karger, Basel, Swiss. pp. 112-124.
36 Hirano, T., T. Ogasawara, S. Hasegawa, M. Iwata, and Y. Nagahama. 1990. Changes in plasma hormone levels during loss of hypoosmoregulatory capacity in mature chum salmon (Oncorhynchus keta) kept in seawater. Gen. Comp. Endocrinol. 78:254-262.   DOI   ScienceOn
37 Onuma, T. A., S. Sato, H. Katsumata, K. Makino, W. Hu, A. Jodo, N. D. Davis, J. T. Dickey, M. Ban, H. Ando, M. Fukuwaka, T. Azumaya, P. Swanson, and A. Urano. 2009. Activity of the pituitary-gonadal axis is increased prior to the onset of spawning migration of chum salmon. J. Exp. Biol. 212:56-70.   DOI   ScienceOn
38 Ueda, H. 2011. Physiological mechanism of homing migration in Pacific salmon from behavioral to molecular biological approaches. Gen. Comp. Endocrinol. 170:222-232.   DOI   ScienceOn
39 Duncan, N. J., C. Selkirk, M. Porter, S. Magwood, and N. Bromage. 2000. The effect of altered photoperiods on maturation of male and female Atlantic salmon (Salmo salar), observations of different responses and mechanisms. In: Proceedings of the 6th International Symposium on the Reproductive Physiology of Fish (Ed. B. Norberg, O. S. Kjesbu, G. L. Taranger, E. Andersson, and S. O. Stefansson). Bergen, Norway. pp. 344.
40 Kikuchi, N., K. Andoh, Y. Abe, K. Yamada, H. Mizunuma, and Y. Ibuki. 2001. Inhibitory action of leptin on early follicular growth differs in immature and adult female mice. Biol. Reprod. 65: 66-71.   DOI   ScienceOn