Effects of Saturated Long-chain Fatty Acid on mRNA Expression of Genes Associated with Milk Fat and Protein Biosynthesis in Bovine Mammary Epithelial Cells |
Qi, Lizhi
(College of Animal Science, Inner Mongolia Agricultural University)
Yan, Sumei (College of Animal Science, Inner Mongolia Agricultural University) Sheng, Ran (College of Animal Science, Inner Mongolia Agricultural University) Zhao, Yanli (College of Animal Science, Inner Mongolia Agricultural University) Guo, Xiaoyu (College of Animal Science, Inner Mongolia Agricultural University) |
1 | Banks, W, J. L. Clapperton, and M. E. Ferrie. 1976. Effect of feeding fat to dairy cows receiving a fat-deficient basal diet. II. Fatty acid composition of the milk fat. J. Dairy Res. 43:219-227. DOI ScienceOn |
2 | Bionaz, M. and J. J. Loor. 2008b. Gene networks driving bovine milk fat synthesis during the lactation cycle. BMC Genomics 9:366. DOI ScienceOn |
3 | Barber, M. C., R. A. Clegg, M. T. Travers, and R. G. Vernon. 1997. Lipid metabolism in the lactating mammary gland. Biochim Biophys Acta. 1347(2-3):101-126. DOI ScienceOn |
4 | Bernard, L., C. Leroux, and Y. Chilliard. 2008. Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland. Adv. Exp. Med. Biol. 606:67-108. DOI |
5 | Bionaz, M. and J. J. Loor. 2008a. ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation. J. Nutr. 138:1019-1024. |
6 | Burgos, S. A., M. Dai, and J. P. Cant. 2010. Nutrient availability and lactogenic hormones regulate mammary protein synthesis through the mammalian target of rapamycin signaling pathway. J. Dairy Sci. 93:153-161. DOI ScienceOn |
7 | Briscoe, C. P., M. Tadayyon, J. L. Andrews, W. G. Benson, J. K. Chambers, M. M. Eilert, C. Ellis, N. A. Elshourbagy, A. S. Goetz, D. T. Minnick, P. R. Murdock, H. R. Sauls Jr., U. Shabon, L. D. Spinage, J. C. Strum, P. G. Szekeres, K. B. Tan, J. M. Way, D. M. Ignar, S. Wilson, and A. I. Muir. 2003. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J. Biol. Chem. 278:11303-11311. DOI ScienceOn |
8 | Cant, J. P., E. J. Depeters, and R. L. Baldwin. 1991. Effect of dietary fat and postruminal casein administration on milk composition of lactating dairy cows. J. Dairy Sci. 74:211-219. DOI |
9 | Cousin, S. P., S. R. Hugl, C. E. Wrede, H Kajio, M. G. Myers, Jr., and C. J. Rhodes. 2001. Free Fatty Acid-Induced Inhibition of Glucose and Insulin-Like Growth Factor I-Induced Deoxyribonucleic Acid Synthesis in the Pancreatic b-Cell Line INS-1. Endocrinology 142:229-240. |
10 | Invernizzi, G., B. J. Thering, M. A. McGuire, G. Savoini, and J. J. Loor. 2010. Sustained upregulation of stearoyl-CoA desaturase in bovine mammary tissue with contrasting changes in milk fat synthesis and lipogenic gene networks caused by lipid supplements. Funct. Integr. Genomics 10:561-575. DOI |
11 | Jenkins, T C. and M. A. Mcguire. 2006. Major advances in nutrition: Impact on milk composition. J. Dairy Sci. 89:1302-1310. DOI ScienceOn |
12 | Furth, P. A., R. E Nakles, S. Millman, E. S. Diaz-Cruz, and M. C. Cabrera. 2011. Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer. Breast Cancer Res. 13:220. DOI ScienceOn |
13 | Hansen, H. O. and J. Knudsen. 1987. Effect of exogenous long-chain fatty acids on lipid biosynthesis in dispersed ruminant mammary gland epithelial cells: Esterification of long-chain exogenous fatty acids. J. Dairy Sci. 70:1344-1349. DOI |
14 | Hu, H., J. Q. Wang, F. D. Li, D. P. Bu, X. Y. Li, and L. Y. Zhou. 2010. Effects of free linolenic acid on transcription of mrnas of genes related to fatty acid metabolism in mammary epithelial cells of dairy cows. Chinese J. Anim. Nutr. 22(5):1342-1349. |
15 | Kadegowda, A. K. G., M Bionaz, L. S. Piperova, R. A. Erdman, and J. J. Loor. 2008. Lipogenic gene expression in MAC-T cells is affected differently by fatty acids and enhanced by PPAR-gamma activation. J. Dairy Sci. 91(E-Suppl.1):678. |
16 | Lehner, R. and A. Kuksis. 1996. Biosynthesis of triacylglycerols. Prog. Lipid Res. 35:169-201. DOI ScienceOn |
17 | Kadegowda, A. K. G., M. Bionaz, L. S. piperova, R. A. Erdman, and J. J. Loor. 2009. Peroxisome proliferator-activated receptor- activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents. J. Dairy Sci. 92:4276-4289. DOI ScienceOn |
18 | Kim, J. E. and J. Chen. 2004. Regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes 53:2748-2756. DOI ScienceOn |
19 | Livak, K. J. and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the method. Methods 25:402-408. DOI ScienceOn |
20 | Laplante, M. and D. M. Sabatini. 2009. mTOR signaling at a glance. J. Cell Sci. 122:3589-3594. DOI ScienceOn |
21 | McArthur, M. J., B. P. Atshaves, A. Frolov, W. D. Foxworth, A. B. Kier, and F. Schroeder. 1999. Cellular uptake and intracellular trafficking of long chain fatty acids. J. Lipid Res. 40:1371-1383. |
22 | Noble, R. C., W. Steele, and J. H. Moore. 1969. The effects of dietary palmitic and stearic acids on milk fat composition in the cow. J. Dairy Res. 36:375-381. DOI |
23 | Ntambi, J. M. and M. Miyazaki. 2003. Recent insights into stearoyl-CoA desaturase-1. Curr. Opin. Lipidol. 14:255-261. DOI ScienceOn |
24 | Palmquist, D. L. 2006. Milk fat: Origin of fatty acids and influence of nutritional factors thereon. In: Advanced Dairy Chemistry Volume 2 Lipids (Ed. P. F. Fox and P. L. H. McSweeney). Springer, New York. pp. 43-92. |
25 | Pauloin, A., S. Chat, C. Pechoux, C. Hue-Beauvais, S. Droineau, L. Galio, E. Devinoy, and E. Chanat. 2010. Oleate and linoleate stimulate degradation of -casein in prolactin-treated HC11 mouse mammary epithelial cells. Cell Tissue Res. 340:91-102. DOI |
26 | Ramirez-Zacarias, J. L., F. Castro-Munozledo, and W. Kuri-Harcuch. 1992. Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O. Histochemistry 97:493-497. DOI ScienceOn |
27 | Soliman, G. A. 2011. The integral role of mTOR in lipid metabolism. Cell Cycle 10:861-862. DOI |
28 | Weisbjerg, M. R., L. Wiking, N. B. Kristensen, and P. Lund. 2008. Effects of supplemental dietary fatty acids on milk yield and fatty acid composition in high and medium yielding cows. J. Dairy Res. 75:142-152. |
29 | Thering, B. J., D. E. Graugnard, P. Piantoni, and J. J. Loor. 2009. Adipose tissue lipogenic gene networks due to lipid feeding and milk fat depression in lactating cows. J. Dairy Sci. 92:4290-4300. DOI ScienceOn |
30 | Warntjes, J. L., P. H. Robinson, E. Galo, E. J. DePeters, and D. Howes. 2008. Effects of feeding supplemental palmitic acid (C16:0) on performance and milk fatty acid profile of lactating dairy cows under summer heat. Anim. Feed Sci. Technol. 140: 241-257. DOI ScienceOn |
31 | Wright, T. C., J. P. Cant, and B. W. McBrid. 2002. Inhibition of fatty acid synthesis in bovine mammary homogenate by palmitic acid is not a detergent effect. J. Dairy Sci. 85:642-647. DOI ScienceOn |
32 | Yonezawa, T., M. Sanosaka, S. Haga, Y. Kobayashi, K. Katoh, and Y. Obara. 2008a. Regulation of uncoupling protein 2 expression by long-chain fatty acids and hormones in bovine mammary epithelial cells. Biochem. Biophys. Res. Commun. 375:280-285. DOI ScienceOn |
33 | Yonezawa, T., S. Haga, Y. Kobayashi, K. Katoh, and Y. Obara. 2008b. Unsaturated fatty acids promote proliferation via ERK1/2 and Akt pathway in bovine mammary epithelial cells. Biochem. Biophys. Res. Commun. 367:729-735. DOI ScienceOn |
34 | Jenkins, T. C. 1999. Lactation performance and fatty acid composition of milk from Holstein cows fed 0 to 5% oleamide. J. Dairy Sci. 82:1525-1531. DOI ScienceOn |
35 | Yonezawa, T., S. Yonekura, Y. Kobayashi, A. Hagino, K. Katoh, and Y. Obara. 2004. Effects of long-chain fatty acids on cytosolic triacylglycerol accumulation and lipid droplet formation in primary cultured bovine mammary epithelial cells. J. Dairy Sci. 87:2527-2534. DOI ScienceOn |
36 | Spitsberg, V. L., E. Matitashvili, and R. C. Gorewit. 1995. Association and coexpression of fatty-acid-binding protein and glycoprotein CD36 in the bovine mammary gland. Eur. J. Biochem. 230:872-878. DOI |