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http://dx.doi.org/10.5713/ajas.2012.12514

Genetic Polymorphisms of the Bovine NOV Gene Are Significantly Associated with Carcass Traits in Korean Cattle  

Kim, B.S. (Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration)
Kim, S.C. (Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration)
Park, C.M. (Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration)
Lee, S.H. (Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration)
Cho, S.H. (Animal Production Division, National Institute of Animal Science, RDA)
Kim, N.K. (Division of Genetic Analysis Lab, Experiment Reserch Institute, National Agricultural Products Quality Management Service of Animal Science)
Jang, G.W. (Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration)
Yoon, D.H. (Department of Animal Science, Kyungpook National University)
Yang, B.S. (Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration)
Hong, S.K. (Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration)
Seong, H.H. (Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration)
Choi, B.H. (Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.26, no.6, 2013 , pp. 780-787 More about this Journal
Abstract
The objective of this study was to investigate single nucleotide polymorphisms (SNPs) in the bovine nephroblastoma overexpressed (NOV) gene and to evaluate whether these polymorphisms affect carcass traits in the Korean cattle population. We resequenced to detect SNPs from 24 unrelated individuals and identified 19 SNPs within the full 8.4-kb gene, including the 1.5-kb promoter region. Of these 19 SNPs, four were selected for genotyping based on linkage disequilibrium (LD). We genotyped 429 steers to assess the associations of these four SNPs with carcass traits. Statistical analysis revealed that g.7801T>C and g.8379A>C polymorphisms in the NOV gene were associated with carcass weight (p = 0.012 and 0.008, respectively), and the g.2005A>G polymorphism was associated with the back fat thickness (BF) trait (p = 0.0001). One haplotype of the four SNPs (GGTA) was significantly associated with BF (p = 0.0005). Our findings suggest that polymorphisms in the NOV gene may be among the important genetic factors affecting carcass yield in beef cattle.
Keywords
NOV Gene; Single Nucleotide Polymorphism; Carcass Weight; Back Fat Thickness; Korean Cattle;
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1 Lee, S. H., J. H. van der Werf, N. K. Kim, S. H. Lee, C. Gondro, E. W. Park, S. J. Oh, J. P. Gibson and J. M. Thompson. 2011. QTL and gene expression analyses identify genes affecting carcass weight and marbling on BTA14 in Hanwoo (Korean Cattle). Mamm. Genome 22:589-601.   DOI   ScienceOn
2 Bork, P. 1993. The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett. 327:125-130.   DOI   ScienceOn
3 Casas, E., S. D. Shackelford, J. W. Keele, R. T. Stone, S. M. Kappes and Koohmaraie. 2000. Quantitative trait loci affecting growth and carcass composition of cattle segregating alternate forms of myostatin. J. Anim. Sci. 78:560-569.
4 Collet, C. and J. Candy. 1998. How many insulin-like growth factor binding proteins? Mol. Cell. Endocrinol. 139:1-6.   DOI   ScienceOn
5 Ferrell, C. L. and T. G. Jenkins. 1984. Relationships among various body components of mature cows. J. Anim. Sci. 58:222-233.
6 Grotendorst, G. R. 1997. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev. 8:171-179.   DOI   ScienceOn
7 Hedrick, P. W. 1987. Gametic disequilibrium measures: proceed with caution. Genetics 117:331-341.
8 Hermesmeyer, G. N., L. L. Berger, T. G. Nash and R. T. Brandt Jr. 2000. Effects of energy intake, implantation, and subcutaneous fat end point on feedlot steer performance and carcass composition. J.Anim. Sci. 78:825-831.
9 Joliot, V., C. Martinerie, G. Dambrine, G. Plassiart, M. Brisac, J. Crochet and B. Perbal. 1992. Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas. Mol. Cell Biol. 12:10-21.
10 Katsube, K., K. Sakamoto, Y. Tamamura and A. Yamaguchi. 2009. Role of CCN, a vertebrate specific gene family, in development. Dev. Growth Differ. 51:55-67.
11 Martinerie, C., E. Viegas-Pequignot, I. Guenard, B. Dutrillaux, V. C. Nguyen, A. Bernheim, B. Perbal. 1992. Physical mapping of human loci homologous to the chicken nov proto-oncogene. Oncogene 7:2529-2534.
12 McClure, M. C., N. S. Morsci, R. D. Schnabel, J. W. Kim, P. Yao, M. M. Rolf, S. D. McKay, S. J. Gregg, R. H. Chapple, S. L. Northcutt and J. F. Taylor. 2010. A genome scan for quantitative trait loci influencing carcass, post-natal growth and reproductive traits in commercial Angus cattle. Anim. Genet. 41:597-607.   DOI   ScienceOn
13 Moon, S. S., I, H. Hwang, S. K. Jin, J. G. Lee, S. T. Joo and G. B. Park. 2003. Carcass traits determining quality and yield grades of Hanwoo steers. Asian Australas. J. Anim. 16:1049-1054.   과학기술학회마을   DOI
14 Moussad, E. E. and D. R. Brigstock. 2000. Connective tissue growth factor: what's in a name? Mol. Genet. Metab. 71:276-292.   DOI   ScienceOn
15 Oberst, C., M. Hartl, R. Weiskirchen and K. Bister. 1999. Conditional cell transformation by doxycycline-controlled expression of the MC29 v-myc allele. Virology 253:193-207.   DOI   ScienceOn
16 Snaith, M. R., D. Natarajan, L. B. Taylor C. P. Choi, C. Martinerie, B. Perbal, P. N. Schofield and C. A. Boulter. 1996. Genomic structure and chromosomal mapping of the mouse nov gene. Genomics 38:425-428.   DOI   ScienceOn
17 Stephens, M., N. J. Smith and P. Donnelly. 2001. A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68:978-989.   DOI   ScienceOn
18 Wibowo, T. A., C. T. Gaskins, R. C. Newberry, G. H. Thorgaard, J. J. Michal and Z. Jiang. 2008. Genome assembly anchored QTL map of bovine chromosome 14. Int. J. Biol. Sci. 4:406-414.   DOI
19 Ying Z. and M. L. King. 1996. Isolation and characterization of xnov, a Xenopus laevis ortholog of the chicken nov gene. Gene 171:243-248.   DOI   ScienceOn
20 APGS. 1995. Report of business for animal products grading.: Animal products garding system, National Livestock Co-operatives Federation, Korea.
21 Liu, C., X. J. Liu, P. D. Crowe, G. S. Kelner, J. Fan, G. Barry, F. Manu, N. Ling, E. B. De Souza, R. A. Maki. 1999. Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation. Gene 238:471-478.   DOI   ScienceOn