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http://dx.doi.org/10.5713/ajas.2011.11347

Identification of Candidate Genes Associated with Beef Marbling Using QTL and Pathway Analysis in Hanwoo (Korean Cattle)  

Park, Hye-Sun (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration)
Seo, Seong-Won (Department of animal biosystem science, Chung-nam National University)
Cho, Yong-Min (Green growth and future strategy team, Director general for planning and coordination, Rural Development Administration)
Oh, Sung-Jong (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration)
Seong, Hwan-Hoo (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration)
Lee, Seung-Hwan (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration)
Lim, Da-Jeong (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.25, no.5, 2012 , pp. 613-620 More about this Journal
Abstract
Marbling from intramuscular fat is an important trait of meat quality and has an economic benefit for the beef industry. Quantitative trait loci (QTL) fine mapping was performed to identify the marbling trait in 266 Hanwoo steers using a 10K single nucleotide polymorphism panel with the combined linkage and linkage disequilibrium method. As a result, we found nine putative QTL regions for marbling: three on BTA6, two on BTA17, two on BTA22, and two on BTA29. We detected candidate genes for marbling within 1 cM of either side of the putative QTL regions. Additionally, to understand the functions of these candidate genes at the molecular level, we conducted a functional categorization using gene ontology and pathway analyses for those genes involved in lipid metabolism or fat deposition. In these putative QTL regions, we found 95 candidate genes for marbling. Using these candidate genes, we found five genes that had a direct interaction with the candidate genes. We also found SCARB1 as a putative candidate gene for marbling that involves fat deposition related to cholesterol transport.
Keywords
Hanwoo; Marbling; QTL Fine Mapping;
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