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http://dx.doi.org/10.5713/ajas.2011.10453

Association of Polymorphisms in Fecundity Genes of GDF9, BMP15 and BMP15-1B with Litter Size in Iranian Baluchi Sheep  

Moradband, F. (Laboratory for Molecular Genetics and Animal Biotechnology, Department of Animal Sciences, Faculty of Animal and Aquatic Sciences, Sari Agricultural Sciences and Natural, Resources University)
Rahimi, G. (Laboratory for Molecular Genetics and Animal Biotechnology, Department of Animal Sciences, Faculty of Animal and Aquatic Sciences, Sari Agricultural Sciences and Natural, Resources University)
Gholizadeh, M. (Laboratory for Molecular Genetics and Animal Biotechnology, Department of Animal Sciences, Faculty of Animal and Aquatic Sciences, Sari Agricultural Sciences and Natural, Resources University)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.24, no.9, 2011 , pp. 1179-1183 More about this Journal
Abstract
The incidence of mutation in three loci of GDF9, BMP15 and BMP15-1B and their effects on litter sizes was evaluated in Baluchi sheep. Wild-type alleles were detected for BMP15 and BMP15-1B loci and all individuals were found to be as non-carriers for FecB and $FecX^G$ mutations but, a G to A nucleotide substitution was found in GDF9 locus. The frequency of $FecG^+$ (0.82) wild type allele was higher than the frequency of $FecG^l$ (0.18) mutant allele and the frequencies of $FecG^+/FecG^+$, $FecG^+/FecG^1$ and $FecG^1/FecG^1$ genotypes were 0.72, 0.20 and 0.08, respectively in GDF9 locus. The heterozygous ($FecG^+/FecG^1$) and homozygous ($FecG^+/FecG^+$) non-carrier ewes had 0.35 and 0.21 more lambs than the homozygous ($FecG^1/FecG^1$) carrier ewes, respectively (p<0.05). In addition to the finding of segregation of non-additive gene effect on litter size in the previous study in Baluchi sheep, these findings for the first time shows that the $FecG^1$ gene has a major effect on litter size in this breed.
Keywords
BMP15; BMP15-1B; GDF9; Litter Size; Baluchi Sheep;
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