The Effect of Melatonin on Mitochondrial Function in Endotoxemia Induced by Lipopolysaccharide
![]() ![]() |
Liu, Jing
(College of Veterinary Medicine, South China Agricultural University)
Wu, Fengming (College of Veterinary Medicine, South China Agricultural University) Liu, Yuqing (College of Veterinary Medicine, South China Agricultural University) Zhang, Tao (College of Veterinary Medicine, South China Agricultural University) Tang, Zhaoxin (College of Veterinary Medicine, South China Agricultural University) |
1 | Acuna-Castroviejo, D., G. Escames, J. Leon, A. Carozo and H. Khaldy. 2003. Mitochondrial regulation by melatonin and its metabolites. Adv. Exp. Med. Biol. 527:549-557. DOI |
2 | Acuna-Castroviejo, D., M. Martin, M. Macias, G. Escames, J. Leon, H. Khaldy and R. J. Reiter. 2001. Melatonin, mitochondria, and cellular bioenergetics. J. Pineal Res. 30:65-74. DOI ScienceOn |
3 | Allegra, M., R. J. Reiter, D. X. Tan, C. Gentile, L. Tesoriere and M. A. Livrea. 2003. The chemistry of melatonin's interaction with reactive species. J. Pineal Res. 34:1-10. DOI ScienceOn |
4 |
Anatoly, A. S. and F. Gary. 2003. Regulation of brain mitochondrial |
5 | Andrey, V. K., S. Katrin and H. Susanne. 2006. Different effects of endotoxic shock on the respiratory function of liver and heart mitochondria in rats. Am. J. Physiol. Gastrointest. Liver Physol. 290:543-549. DOI ScienceOn |
6 | Tan, D. X., B. Poeggeler, R. J. Reiter, L. D. Chen, S. Chen, L. C. Manchester and L. R. Barlow-Walden. 1993b. The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo. Cancer Lett. 70:65-71. DOI ScienceOn |
7 | Ximenes, V. F., S. O. Silva, M. R. Rodrigues, L. H. Catalani, G. J. Maghzal, A. J. Kettle and A. Campa. 2005. Superoxide dependent oxidation of melatonin by myeloperoxidase. J. Biol. Chem. 280:38160-38169. DOI ScienceOn |
8 | Zavodnik, I. B., E. A. Lapshima, L. B. Zavodnik, M. Labieniec, M. Bryszewska and R. J. Reiter. 2004. Hypochlorous acidinduced oxidative stress in Chinese hamster B14 cells: viability, DNA and protein damage and the protective action of melatonin. Mutat. Res. 559:39-48. DOI ScienceOn |
9 | Tan, D. X., L. C. Manchester, R. J. Reiter, B. F. Plummer, J. Limson, S. T. Weintraub and W. Qi. 2000a. Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin. Free Radic. Biol. Med. 29:1177-1185. DOI ScienceOn |
10 | Tan, D. X., L. D. Chen, B. Poeggeler, L. C. Manchester and R. J. Reiter. 1993a. Melatonin: a potent endogenous hydroxyl radical scavenger. Endocr. J. 1:57-60. |
11 | Tang, Z., M. Iqbal and D. Cawthon. 2002. Heart and breast muscle mitochondrial dysfunction in pulmonary hypertension syndrome in broilers (gallus domesticus). Comp. Biochem. Physiol. Part A 132:527-540. DOI ScienceOn |
12 | Vera, A. V. and C. Christos. 2006. Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol. Sci. 27:639-645. DOI ScienceOn |
13 |
Tatyana, V. V. and J. R. Ian. 2001. |
14 | Tsutsui, H. 2006. Mitochondrial oxidative stress and heart failure. Jap. Soc. Inter. Med. 45:809-813. |
15 | Turrens, J. F. 1997. Superoxie production by the mitochondrial respiratory chain. Biosci. Rep. 17:3-8. DOI ScienceOn |
16 | Wang, Y. L., S. Zhang and Z. X. Tang. 2006. Effect of ainoguanidine on liver mitochondrial free radical metabolism in broilers with endotoxemia. Chin. J. Vet. Sci. 36:143-146. |
17 | Wu, K. K. and P. Thiagarajan. 1996. Role of endothelium in thrombosis and hemostasis. Annu. Rev. Med. 47:315-331. DOI ScienceOn |
18 | Raam, B. J., S. Wim, W. de Elly, R. Dirk, J. V. Arthur and W. K. Taco. 2008. Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organization. PLoS ONE 3:e2013. DOI ScienceOn |
19 | Reiter, R. J., D. X. Tan, L. C. Manchester and W. Qi. 2001a. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. Cel. Physiol. Biochem. 34:237-256. |
20 | Reiter, R. J., D. X. Tan and C. Osuna. 2000. Actions of melatonin in the reduction of oxidative stress: a review. J. Biomed. Sci. 7: 444-458. DOI |
21 | Reiter, R. J., D. X. Tan, L. C. Manchester and M. R. El-Sawi. 2002. Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging. Ann. NY Acad. Sci. 959:238-250. |
22 | Singer, M. and D. Brealey. 1999. Mitochondrial dysfunction in sepsis. Biochem. Soc. Symp. 66:149-166. |
23 | Rodriquez, C., J. C. Mayo and R. J. Saina. 2004. Regulation of antioxidant enzymes: a significant role for melatonin. J. Pineal Res. 36:1-9. DOI ScienceOn |
24 | Rongen, G. A., P. Smits and T. Thien. 1994. Endothelium and the regulation of vascular tone with emphasis on the role of nitric oxide. Physiology, pathophysiology and clinical implications. Neth. J. Med. 44:26-35. |
25 | Shauna, M. D. and K. Aly. 2006. Lipopolysaccharide signaling in endothelial cells. Lab. Invest. 86:9-22. DOI ScienceOn |
26 | Singer, M., V. De Santis, D. Vitale and W. Jeffcoate. 2004. Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet 364:545-548. DOI ScienceOn |
27 | Tan, D. X., L. D. Chen and B. Poeggeler. 1993. Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr. J. 1: 57-60. |
28 | Martinez, G. R., E. A. Almeida, C. F. Klitzke, J. Onuki, F. M. Prado, M. H. Medeiros and P. Di Mascio. 2005. Measurement of melatonin and its metabolites: importance for the evaluation of their biological roles. Endocrine 27:111-118. DOI ScienceOn |
29 | Matthew, M., L. Michael, R. T. David and T. R. Michael. 2006. Mitochondrial respiratory chain supercomplexes are destabilized in barth syndrome patients. J. Mol. Biol. 261:462-469. |
30 | Menendez-Pelaez, A. and R. J. Reiter. 1993. Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization. J. Pineal Res. 15:59-69. DOI |
31 | Michael, R. D. 2000. Mitochondria and calcium: from cell signaling to cell death. J. Phys. 529:57-68. DOI |
32 | Pozo, D., R. J. Reiter, J. R. Calvo and J. M. Guerrero. 1994. Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci. 55:PL455-PL460. DOI ScienceOn |
33 |
Michael, R. D. 2004. Section III: mitochondria, |
34 | Octavio, G., A. Angeles, M. Lourdes and P. B. Juan. 2005. Increased mitochondrial respiration maintains the mitochondrial membrane potential and promotes survival of cerebellar neurons in an endogenous model of glutamate receptor activation. J. Neurochem. 92:183-190. DOI ScienceOn |
35 | Ojano-Dirain, C., M. Iqbal, T. Wing, M. Cooper and W. Bottje. 2005. Glutathione and respiratory chain complex activity in duodenal mitonchondria of broilers with low and high feed efficiency. Poult. Sci. 84:785-788. |
36 | Qun, C., J. V. Edwin, M. Shadi and L. H. Charles. 2003. Production of reactive oxygen species by mitochondria: Central role of complex III. J. Biol. Chem. 278:36027-36031. DOI ScienceOn |
37 | Leon, J., D. Acuna-Castroviejo, G. Escames, D. X. Tan and R. J. Reiter. 2005. Melatonin mitigates mitochondrial malfunction. J. Pineal Res. 38:1-9. DOI ScienceOn |
38 | Leon, J., M. Macias, G. Escames, E. Camacho, H. Khaldy, M. Martin, A. Espinosa, M. A. Gallo and D. Acuna-Castroviejo. 2000. Structure-related inhibition of calmodulin-dependent neuronal nitric-oxide synthase activity by melatonin and synthetic kynurenines. Mol. Pharm. 58:967-975. |
39 | Leon, J., F. Vives, E. Crespo, E. Camacho, A. Espinosa, M. A. Gallo, G. Escames and D. Acuna-Castroviejo. 1998. Modification of nitric oxide synthase activity and neuronal response in rat striatum by melatonin and kynurenine derivatives. J. Neuroendocrinol. 10:297-302. |
40 | Lobo, S. M., D. De Backer, Q. Sun, Z. Tu, G. Dimopoulos, J. C. Preiser, N. Nagy, B. Vray, V. Vercrury, R. G. Terzi and J. L. Vincent. 2003. Gut mucosal damage during endotoxic shock is due to mechanisms other than gut ischemia. J. Appl. Phys. 95:2047-2054. |
41 | Lothar, K. and H. Judy. 2006. The mechanism of superoxide production by NADH: ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc. Nat. Ac. Sci. 103:7607-7612. DOI ScienceOn |
42 | Lu, S. M., S. M. Song, J. C. Liu, H. M. Yang, P. Li and Z. G. Wang. 2003. Changes of proton transportation across the inner mitochondrial membrane and H-ATPase in endotoxic shock rats. Chin. J. Traumatol. 6:292-296. |
43 | Ly, J. D., D. R. Grubb, and A. Lawen. 2003. The mitochondrial membrane potential [Deltapsi(m)] in apoptosis: an update. Apoptosis 8:115-118. DOI ScienceOn |
44 | Marieke, K. B. V. D. W. and Emile De Heer. 1996. Cisplatininduced nephrotoxicity in porcine proximal tubular cells: Mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain. J. Pharmacol. Exp. Ther. 280:638-649. |
45 | Marion, M. B. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254. DOI ScienceOn |
46 | Garcia, J. J., R. J. Reiter, J. Pie, G. G. Ortiz, J. Cabrera, R. M. Sainz and D. Acuna-Castroviejo. 1999. Role of pinoline and melatonin in stabilizing hepatic microsomal membranes against oxidative stress. J. Bioenerg. Biomembr. 31:609-616. DOI ScienceOn |
47 | Giuseppe, P. M.P.a.F.M.R. 2000. The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles. FEBS Lett. 466:323-326. DOI ScienceOn |
48 | Hatefi, Y. and D. L. Stiggall. 1978. Preparation and properties of succinate: ubiquinone reductase (Complex II). Meth. Enzymol. 53: 21-27. DOI |
49 | Haider R., J. Annie, M. B. Eric, B. Sheela and K. Amr. 2006. Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC 12 cells. Toxicol. Appl. Pharmacol. 226:161-168. |
50 | Hartmut, J., J. G. Gregory, I. C. Arthur, A. H. Jack, P. Dominique and J. L. John. 2002. Mech Hepatotox. Toxicol. Sci. 65:166-176. DOI ScienceOn |
51 | Hiroyuki, T. 2006. Mitochondrial oxidative stress and heart failure. Inter. Med. 45:809-813. DOI |
52 | Iqbal, M., D. Cawthon, R. F. Widenman, Jr., K. W. Beers and W. G. Bottje. 2001a. Lung mitochondrial dysfunction in pulmonary hypertension syndrome. II. Oxidative stress and inability to improve function with repeated additions of ADP. Poult. Sci. 80:656-665. DOI |
53 | Jane, A. L. and L. Joseph. 2005. Oxidative enzymopathies and vascular disease. Arterioscler. Thromb. Vas. Biol. 25:1102-1111. DOI ScienceOn |
54 | Kantrow, S. P., D. E. Taylor, M. S. Carraway and C. A. Piantadosi. 1997. Oxidative metabolism in rat hepatocytes and mitochondria during sepsis. Arch. Biochem. Biophys. 345:278-288. DOI ScienceOn |
55 | Kubes, P. 2005. The complexities of leukocyte recruitment. Semin. Immuno. 14:65-72. |
56 | Crespo, E., M. Macias, D. Pozo, G. Escames, M. Martin, F. Vives, J. M. Guerrero and D. Acuna-Castroviejo. 1999. Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharideinduced multiple organ dysfunction syndrome in rats. FASEB J. 13: 1537-1546. |
57 | Elizabeth, A. M. and F. A. Karam. 2004. Effects of enhancing mitochondrial oxidative phosphorylation with reducing equivalents and ubiquinone on 1-methyl-4-phenylpyridinium toxicity and complex I-IV damage in neuroblastoma cells. Biomed. Pharmacother. 67:1167-1184. |
58 | Crouser, E. D. 2004. Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome. Mitochondrion 4: 729-741. DOI ScienceOn |
59 | Crouser, E. D., M. W. Julian, D. V. Blaho and D. R. Pfeiffer. 2002. Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity. Crit. Care Med. 30:276-284. DOI ScienceOn |
60 | Crouser, E. D., M. W. Julian and P. M. Dorinsky. 1999. Ileal VO2- DO2 alterations induced by endotoxin correlate with severity of mitochondrial injury. Am. J. Respir. Crit. Care Med. 160: 1347-1353. DOI ScienceOn |
61 | Escames, G., J. Leon, M. Macias, H. Khaldy and D. Acuna- Castroviejo. 2003. Melatonin counteracts lipopolysaccharideinduced expression and activity of mitochondrial nitric oxide synthase in rats. FASEB J. 17:932-934. |
62 | Fink, M. P. 2001. Cytopathic hypoxia: mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. Crit. Care Clin. 17:219-237. DOI |
63 | Francesca, P., T. Jukka and W. Christian. 2006. Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function. Crit. Care 10:118-130. DOI |
64 | Galente, Y. M. and Y. Hatefi. 1978. Resolution of Complex I and isolation of NADH dehydrogenase and an iron-sulfur protein. Meth. Enzymol. 53:15-21. DOI |
65 | Andreyev, A. Yu, Kushnareva Yu. E. and A. A. Starkov. 2005. Mitochondrial metabolism of reactive oxygen species. Biochem. (Moscow) 70:200-214. DOI |
66 | Bettahi, I., J. M. Guerrero, R. J. Reiter and C. Osuna. 1998. Physiological concentrations of melatonin inhibit the norepinephrineinduced activation of prostaglandin E2 and cyclic AMP production in rat hypothalamus: a mechanism involving inhibiton of nitric oxide synthase. J. Pineal Res. 25: 34-40. DOI ScienceOn |
67 | Aydogen, S., M. B. Yerer and A. Goktas. 2006. Melatonin and nitric oxide. J. Endocrinol. Invest. 29:281-287. DOI |
68 | Barja, G. 1999. Mitochondrial oxygen radicals generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity. J. Bios. Bioe. 31:347-366. |
69 | Bass, D. A., J. W. Parce, L. R. Dechatelet, P. Szejda, M. C. Seeds and M. Thomas M. 1983. Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation. J. Immunol. 130:1910-1915. |
70 | Bi, M. H., S. W. Zhang and B. E. Wang. 2004. The impairment and mechanism of endotoxemia in rat liver mitochondria. J. Chi. Integ. Med. 20:90-91. |
71 | Brealey, D., M. Brand, I. Hargreaves, S. Heales, J. Land, R. Smolenski, N. A. Davies, C. E. Cooper and M. Singer. 2002. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 360:9-223. DOI ScienceOn |
72 | Cawthon, D. C., R. McNew, K. W. Beers and W. G. Bottje. 1999. Evidence of mitochondrial dysfunction in broilers with pulmonary hypertension syndrome (ascites): Effect of t-butyl hydroperoxide on hepatic mitochondrial function, glutathione, and related thiols. Poult. Sci. 78:114-124. DOI |
73 | Costa, E. J., C. S. Shida, M. H. Biaggi, A. S. Ito, M. T. Lamy- Freund. 1997. How melatonin interacts with lipid bilayers: a study by fluorescence and ESR spectroscopies. FEBS Lett. 416: 103-106. DOI ScienceOn |
![]() |