[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5713/ajas.2010.90416

Decreased Complete Oxidation Capacity of Fatty Acid in the Liver of Ketotic Cowsa

Xu, Chuang (Department of Clinical Veterinary Medicine, Animal Science and Technology College, Heilongjiang August First Land Reclamation University)
Liu, Guo-wen (Department of Clinical Veterinary Medicine, Animal and Veterinary College, Jilin University)
Li, Xiao-bing (Department of Clinical Veterinary Medicine, Animal and Veterinary College, Jilin University)
Xia, Cheng (Department of Clinical Veterinary Medicine, Animal Science and Technology College, Heilongjiang August First Land Reclamation University)
Zhang, Hong-you (Department of Clinical Veterinary Medicine, Animal Science and Technology College, Heilongjiang August First Land Reclamation University)
Wang, Zhe (Department of Clinical Veterinary Medicine, Animal and Veterinary College, Jilin University)

Publication Information

Asian-Australasian Journal of Animal Sciences / v.23, no.3, 2010 , pp. 312-317 More about this Journal

Abstract

Complete oxidation of fatty acid in the liver of ketotic cows was investigated. Serum non-esterified fatty acid (NEFA), beta-hydroxybutyric acid (BHBA) and glucose concentrations were measured using biochemical techniques. Carnitine palmitoyl transferase II (CPT II), 3-hydroxy acyl-CoA dehydrogenase (HAD) and oxaloacetic acid (OAA) concentrations in the liver were detected by ELISA. Serum glucose was lower in ketotic cows than controls (p<0.05). Serum BHBA and NEFA concentrations were higher in ketotic cows than controls (p<0.05). OAA, CPT II, and HAD contents in the liver of ketotic cows were lower than in controls (p<0.05). There were negative correlations between serum NEFA concentration and OAA, CPT II and HAD, but no correlation between serum BHBA concentration and capacity for complete oxidation of fatty acid. Overall, the capacity for complete fatty acid oxidation in the liver of ketotic cows might have been decreased. High serum NEFA concentrations may be unfavorable factors for the pathway of complete oxidation of fatty acid in the liver.

Keywords

Dairy Cow; Ketosis, Liver; Fatty Acid Oxidation;

Citations & Related Records

Times Cited By KSCI : 1 (Citation Analysis)
Times Cited By Web Of Science : 2 (Related Records In Web of Science)
Times Cited By SCOPUS : 0

Reference
Cited By KSCI

1	Carlson, D. B., J. W. McFadden, A. D'Angelo, J. C. Woodworth and J. K. Drackley. 2007. Dietary L-carnitine affects periparturient nutrient metabolism and lactation in multiparous cows. J. Dairy Sci. 90:3422-3441 DOI ScienceOn
2	Duffield, T. 2000. Subclinical ketosis in lactating dairy cattle. Vet. Clin. N. AM-Food. A. 16:231-253 PUBMED
3	Murondoti, A., R. Jorritsma, A. C. Beynen, T. Wensing and M. J. Geelen. 2004. Unrestricted feed intake during the dry period impairs the postpartum oxidation and synthesis of fatty acids in the liver of dairy cows. J. Dairy Sci. 87:672-679 DOI ScienceOn
4	Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Chem. 72:248-254 DOI PUBMED ScienceOn
5	Carlson, D. B., L. B. Litherland, H. M. Dann, J. C. Woodworth and J. K. Drackley. 2006. Metabolic effects of abomasal Lcarnitine infusion and feed restriction in lactating Holstein cows. J. Dairy Sci. 89:4819-4834 DOI ScienceOn
6	Loor, J. J., R. E. Everts, M. Bionaz, H. M. Dann, D. E. Morin, R. Oliveira, S. L. Rodriguez-Zas, J. K. Drackley and H. A. Lewin. 2007. Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows. Physiol. Genomics 32(1):105-116 DOI ScienceOn
7	Geishauser, T., K. Leslie, J. Tenhag and A. Bashiri. 2000. Evaluation of eight cow-side ketone tests in milk for detection of subclinical ketosis in dairy cows. J. Dairy Sci. 83:296-299 DOI ScienceOn
8	Oikawa, S., N. Katoh, F. Kawawa and Y. Ono. 1997. Decreased serum apolipoprotein B-100 and A-I concentrations in cows with ketosis and left displacement of the abomasums. Am. J. Vet. Res. 58:121-125 PUBMED ScienceOn
9	Jonas, R. and W. Huth. 1978. Acetyl-CoA acetyltransferase from bovine liver mitochondria. Molecular properties of multiple forms. Biochim. Biophys. Acta. 527:379-390 DOI PUBMED ScienceOn
10	Ingvartsen, K. L. 2006. Feeding- and management-related diseases in the transition cow Physiological adaptations around calving and strategies to reduce feeding-related diseases. Anim. Feed Sci. Technol. 126:175-213 DOI ScienceOn
11	Melendez, P., J. P. Goff, C. A. Risco, L. F. Archbald, R. Littell and G. A. Donovan. 2006. Incidence of subclinical ketosis in cows supplemented with a monensin controlled-release capsule in Holstein cattle, Florida, USA. Prev. Vet. Med. 73:33-42 DOI ScienceOn
12	Chuang, X. and Z. Wang. 2008. Comparative proteomic analysis of livers from ketotic cows. Vet. Res. Commun. 32:263-273 DOI PUBMED
13	Kristensen, N. B. and B. M. Raun. 2007. Ruminal and intermediary metabolism of propylene glycol in lactating Holstein cows. J. Dairy Sci. 90:4707-4717 DOI ScienceOn
14	Grummer, R. R. 1995. Impact of changes in organic nutrient metabolism on feeding the transition dairy cow. J. Anim. Sci. 73:2820-2833 PUBMED ScienceOn
15	Yamamoto, M., H. Nakagawa-Ueta, N. Katoh and S. Oikawa. 2001. Decreased concentration of serum apolipoprotein C-III in cows with fatty liver, ketosis, left displacement of the abomasum, milk fever and retained placenta. J. Vet. Med. Sci. 63:227-231 DOI ScienceOn
16	Xu, C., Z. Wang, G. W. Liu, X. B. Li, G. H. Xie, C. Xia and H. Y. Zhang. 2008. Metabolic characteristic of the liver of dairy cows during ketosis based on comparative proteomics. Asian-Aust. J. Anim. Sci. 21:1003-1008
17	Grummer, R. R. 1993. Etiology of lipid-related metabolic disorders in periparturient dairy cows. J. Dairy Sci. 76:3882-3896 DOI PUBMED ScienceOn
18	Grummer, R. R. 2008. Nutritional and management strategies for the prevention of fatty liver in dairy cattle. Vet. J. 176:10-20 DOI ScienceOn
19	Hoppel, C. L. 1982. Carnitine and carnitine palmitoyltransferase in fatty acid oxidation and ketosis. Fed. Proc. 41(12):2853-2857 PUBMED ScienceOn
20	Dann, H. M. and J. K. Drackley. 2005. Carnitine palmitoyltransferase I in liver of periparturient dairy cows: effects of prepartum intake, postpartum induction of ketosis, and periparturient disorders. J. Dairy Sci. 88:3851-3859 DOI ScienceOn

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7	(2012) Applied and Environmental Microbiology Correlation between Composition of the Bacterial Community and Concentration of Volatile Fatty Acids in the Rumen during the Transition Period and Ketosis in Dairy Cows / 78 (7) , 2386
1751-732X	(2018) animal Molecular mechanisms of lipid metabolism disorder in livers of ewes with pregnancy toxemia / (1751-732X) , 1
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