Dietary L-arginine Supplementation Improves Intestinal Function in Weaned Pigs after an Escherichia coli Lipopolysaccharide Challenge
![]() ![]() |
Liu, Yulan
(State Key Laboratory of Animal Nutrition, China Agricultural University)
Han, Jie (Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University) Huang, Jingjing (Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University) Wang, Xiaoqiu (State Key Laboratory of Animal Nutrition, China Agricultural University) Wang, Fenglai (State Key Laboratory of Animal Nutrition, China Agricultural University) Wang, Junjun (State Key Laboratory of Animal Nutrition, China Agricultural University) |
1 | Zhang, L. P., C. Y. Yang, Y. P. Wang, F. Cui and Y. Zhang. 2008. Protective effect of polydatin against ischemia/reperfusion injury in rat heart. Acta Physiologica Sinica 60:161-168 |
2 | AOAC. 1990. Official methods of analysis (15th Ed.). Association of Official Analytical Chemists, Washington, DC |
3 | Fink, M. P., J. B. Antonsson, H. L. Wang and H. R. Rothschild. 1991. Increased intestinal permeability in endotoxic pigs. Mesenteric hypoperfusion as an etiologic factor. Arch. Surg. 126:211-218 DOI ScienceOn |
4 | Gurbuz, A. T., J. Kunzelman and E. E. Ratzer. 1998. Supplemental dietary arginine accelerates intestinal mucosal regeneration and enhances bacterial clearance following radiation enteritis in rats. J. Surg. Res. 74:149-154 DOI ScienceOn |
5 | Han, J., Y. L. Liu, W. Fan, J. Chao, Y. Q. Hou, Y. L. Yin, H. L. Zhu, G. Q. Meng and Z. Q. Che. 2008. Dietary L-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs. Amino Acids 10.1007/s00726-008-0184-9 PUBMED |
6 | Kobayashi, H., T. Nonami, T. Kurokawa, Y. Takeuchi, A. Harada, A. Nakao and H. Takagi. 1995. Role of endogenous nitric oxide in ischemia-reperfusion injury in rat liver. J. Surg. Res. 59:772-779 DOI ScienceOn |
7 | Kruzel, M. L., Y. Harari, C. Y. Chen and G. A. Castro. 2000. Lactoferrin protects gut mucosal integrity during endotoxemia induced by lipopolysaccharide in mice. Inflammation 24:33-44 DOI ScienceOn |
8 | NRC. 1998. Nutrient requirements of swine (10th Ed.). National Academic Press, Washington, DC |
9 | Rhoden, E. L., L. Pereira-Lima, C. R. Rhoden, M. L. Lucas, C. Teloken and A. Bello-Klein. 2001. Role of the L-arginine/nitric oxide pathway in renal ischaemia-reperfusion in rats. Eur. J. Surg. 167:224-228 DOI ScienceOn |
10 | Semrad, S. D. 2005. Malassimilation syndromes in large animals. In: Merck veterinary manual, ninth ed. (Ed. C. M. Kahn). Merck Co. Inc., Whitehouse Station, NJ, USA. pp. 301-306 |
11 | Verdonk, J. M. A. J., M. A. M. Spreeuwenberg, G. C. M. Bakker and M. W. A. Verstegen. 2001. Nutrient intake level affects histology and permeability of the small intestine in newly weaned piglets. In Digestive physiology of pigs (Ed. J. E. Lindberg and B. Ogle). pp. 332-334. Wallingford, UK: CABI Publishing |
12 | Wang, J. J., L. X. Chen, D. F. Li, Y. L. Yin, X. Q. Wang, P. Li, L. J. Dangott, W. X. Hu and G. Y. Wu. 2008a. Intrauterine growth restriction affects the proteomes of the small intestine, liver, and skeletal muscle in newborn pigs. J. Nutr. 138:60-66 PUBMED |
13 | Wu, G., D. A. Knabe and S. W. Kim. 2004. Arginine nutrition in neonatal pigs. J. Nutr. 134:2783S-2390S |
14 | Wu, G., C. J. Meininger, D. A. Knabe, F. W. Bazer and J. M. Rhoads. 2000. Arginine nutrition in development, health and disease. Curr. Opin. Clin. Nutr. Metab. Care 3:59-66 DOI ScienceOn |
15 | Yao, K., Y. L. Yin, W. Y. Chu, Z. Q. Liu, D. Deng, T. J. Li, R. L. Huang, J.S. Zhang, B. Tan, W. C. Wang and G. Y. Wu. 2008. Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs. J. Nutr. 138:867-872 DOI PUBMED |
16 | Kohli, R., C. J. Meininger, T. E. Haynes, W. Yan, J. T. Self and G. Wu. 2004. Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats. J. Nutr. 134:600-608 PUBMED |
17 | Lowry, O. H., N. J. Rosebrough, A. L. Farr and R. J. Randall. 1951. Protein measurement with folin phenol reagent. J. Biol. Chem. 193:265-275 PUBMED |
18 | Spanos, C. P., P. Papaconstantinou, P. Spanos, M. Karamouzis, G. Lekkas and C. Papaconstantinou. 2007. The effect of Larginine and aprotinin on intestinal ischemia-reperfusion injury. J. Gastrointest. Surg. 11:247-255 DOI ScienceOn |
19 | Wu, G., F. W. Bazer, T. A. Cudd, W. S. Jobgen, S. W. Kim, A. Lassala, P. Li, J. H. Matis, C. J. Meininger and T. E. Spencer. 2007a. Pharmacokinetics and safety of arginine supplementation in animals. J. Nutr. 137:1673S-1680S DOI ScienceOn |
20 |
Corl, B. A., J. Odle, X. M. Niu, A. J. Moeser, L. A. Gatlin, O. T. Phillips, A. T. Blikslager and J. M. Rhoads. 2008. Arginine activates intestinal |
21 | Fotiadis, C., S. Adamis, E. P. Misiakos, M. Genetzakis, P. T. Antonakis, D. K. Tsekouras, V. G. Gorgoulis, G. C. Zografos, A. Papalois, M. Fotinou and D. Perrea. 2007. The prophylactic effect of L-arginine in acute ischaemic colitis in a rat model of ischaemia/reperfusion injury. Acta Chir. Belg. 107:192-200 PUBMED |
22 | Hampson, D. J. and D. E. Kidder. 1986. Influence of creep feeding and weaning on brush border enzyme activities in the piglet small intestine. Res. Vet. Sci. 40:24-31 PUBMED |
23 | Liu, K. X., T. Rinne, W. He, F. Wang and Z. Y. Xia. 2007. Propofol attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in the rat. Can. J. Anesth. 54:366-374 DOI ScienceOn |
24 | Mansoori, B., H. Nodeh, M. Modirsanei, S. Rahbari and P. Aparnak. 2009. d-Xylose absorption test: A tool for the assessment of the effect of anticoccidials on the intestinal absorptive capacity of broilers during experimental coccidiosis. Anim. Feed Sci. Technol. 148:301-308 DOI ScienceOn |
25 | Gao, C. J., W. Chai, L. X. Xu, G. H. Zhang, H. Zhang, L. C. Han and X. D. Sun. 2006. Protective effects of hyperoxygenated solution preconditioning on intestinal ischemia-reperfusion injury in rabbits. J. Surg. Res. 135:268-274 DOI ScienceOn |
26 | Wang, W. W., S. Y. Qiao and D. F. Li. 2009. Amino acids and gut function. Amino Acids 37:105-110 DOI ScienceOn |
27 | Miguez, I., G. Marino, B. Rodríguez and C. Taboada. 2004. Effects of dietary L-arginine supplementation on serum lipids and intestinal enzyme activities in diabetic rats. J. Physiol. Biochem. 60:31-37 DOI ScienceOn |
28 | Hou, Y. Q., Y. L. Liu, J. Hu and W. H. Shen. 2006. Effects of lactitol and tributyrin on growth performance, small intestinal morphology and enzyme activity in weaned pigs. Asian-Aust. J. Anim. Sci. 19:1470-1477 |
29 | Liu, G. P., W. P. Zhou, W. X. Zhu, G. M. Cheng, S. J. Jiang and S. G. He. 2003. The protective effect of L-arginine on the intestine barrier of rats with obstructive jaundice. J. Hepatobiliary Surg. 11:153-154 (Chinese) |
30 | Orlando, G. F., G. Wolf and M. Engelmann. 2008. Role of neuronal nitric oxide synthase in the regulation of the neuroendocrine stress response in rodents: insights from mutant mice. Amino Acids 35:17-27 DOI ScienceOn |
31 | Zhan, Z. F., D. Y. Ou, X. S. Piao, S. W. Kim, Y. H. Liu and J. J. Wang. 2008. Dietary arginine supplementation affects microvascular development in the small intestine of earlyweaned pigs. J. Nutr. 138:1304-1309 PUBMED |
32 | Mercer, D. W., G. S. Smith, J. M. Cross, D. H. Russell, L. Chang and J. Cacioppo. 1996. Effects of lipopolysaccharide on intestinal injury: potential role of nitric oxide and lipid peroxidation. J. Surg. Res. 63:185-192 DOI ScienceOn |
33 |
Liu, Y. L., J. Lu, J. X. Shi, Y. Q. Hou, H. L. Zhu, S. J. Zhao, H. M. Liu, B. Y. Ding, Y. L. Yin and G. F. Yi. 2008b. Increased expression of the peroxisome proliferator-activated receptor |
34 | Liu, Y., H. Liu and Q. Y. Kong. 2005. The roles of superoxide dismutase, nitric oxide synthase and nitric oxide in the antitumor mechanism of arsenic trioxide. Acta Acad. Med. Xuzhou. 25:8-12 |
35 | Peng, X., H. Yan, Z. Y. You, P. Wang and S. L. Wang. 2004. Effects of enteral supplementation with glutamine granules on intestinal mucosal barrier function in severe burned patients. Burns 30:135-139 DOI ScienceOn |
36 | Schleiffer, R. and F. Raul. 1996. Prophylactic administration of Larginine improves the intestinal barrier function after mesenteric ischaemia. Gut 39:194-198 DOI ScienceOn |
37 | Sukhotnik, I., J. Mogilner, M. M. Krausz, M. Lurie, M. Hirsh, A. G. Coran and E. Shiloni. 2004. Oral arginine reduces gut mucosal injury caused by lipopolysaccharide endotoxemia in rat. J. Surg. Res. 122:256-262 DOI ScienceOn |
38 | Wang, J. J., L. X. Chen, P. Li, X. L. Li, H. J. Zhou, F. L. Wang, D. F. Li, Y. L. Yin and G. Y. Wu. 2008b. Gene expression is altered in piglet small intestine by weaning and dietary glutamine supplementation. J. Nutr. 138:1025-1032 PUBMED |
39 | Chander, V. and K. Chopra. 2005. Renal protective effect of molsidomine and L-arginine in ischemia-reperfusion induced injury in rats. J. Surg. Res. 128:132-139 DOI ScienceOn |
40 | Wu, G., F. W. Bazer, T. A. Davis, L. A. Jaeger, G. A. Johnson, S. W. Kim, D. A. Knabe, C. J. Meininger, T. E. Spencer and Y. L. Yin. 2007b. Important roles for the arginine family of amino acids in swine nutrition and production. Livest. Sci. 112:8-22 DOI ScienceOn |
41 | Fang, Y. Z., S. Yang and G. Y. Wu. 2002. Free radicals, antioxidants, and nutrition. Nutrition 18:872-879 DOI ScienceOn |
42 | Liu, Y. L., J. J. Huang, Y. Q. Hou, H. L. Zhu, S. J. Zhao, B. Y. Ding, Y. L. Yin, G. F. Yi, J. X. Shi and W. Fan. 2008a. Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs. Br. J. Nutr. 100:552-560 DOI ScienceOn |
43 | Sukhotnik, I., H. Helou, J. Mogilner, M. Lurie, A. Bernsteyn, A. G. Coran and E. Shiloni. 2005. Oral arginine improves intestinal recovery following ischemia-reperfusion injury in rat. Pediatr. Surg. Int. 21:191-196 DOI ScienceOn |
44 | Zheng, C. T., T. Wang, Z. N. Lu, S. G. Zou, R. J. Xu and J. S. Zhang. 1999. EFfects of oral insulin and trypsinized formula milk on small intestinal growth and development in newborn pigs. Acta Veterinaria et Zootechnica Sinica. 30:405-413 (Chinese) |
45 | Zhang, C., Z. Y. Sheng, S. Hu, J. C. Gao, S. Yu and Y. Liu. 2002. The influence of apoptosis of mucosal epithelial cells on intestinal barrier integrity after scald in rats. Burns 28:731-737 DOI ScienceOn |
![]() |