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http://dx.doi.org/10.5713/ajas.2008.r.05

Growth Hormone Signaling in the Regulation of Acid Labile Subunit  

Kim, Jin Wook (Department of Animal Science, College of Agriculture and Life Sciences, Cornell University)
Boisclair, Yves R. (Division of Applied Life Sciences (Institute of Agriculture and Life Science), College of Agriculture and Life Sciences Gyeongsang National University)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.21, no.5, 2008 , pp. 754-768 More about this Journal
Abstract
The past decades have seen enormous advances in our understanding of how GH acts. GH is a pituitary-derived polypeptide hormone that has diverse physiological effects including the regulation of bone growth, carbohydrate and lipid metabolism. The effects of GH are mediated directly and indirectly through IGF-I. In addition, GH stimulates the hepatic production of ALS. In postnatal life, IGF-I and -II circulate as 150 kDa ternary complexes consisting of one molecule each of IGFBP-3 or IGFBP-5, IGF-I or IGF-II and ALS. It is now known that ALS increases significantly the half-lives of the IGFs, IGFBP-3 and -5, and therefore is responsible for maintaining a circulating reservoir for each of these proteins.
Keywords
Growth Hormone; Signaling; Acid Labile Subunit;
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