Browse > Article
http://dx.doi.org/10.5713/ajas.2007.1496

Skin Deiodinase Profiles after Melatonin Manipulated in Chinese Inner Mongolia Cashmere Goats  

Yue, Chunwang (College of Animal Science and Technology, China Agricultural University)
Du, Lixin (Institute of Animal Science Chinese Academy of Agricultural Sciences)
Zhu, Xiaoping (College of Animal Science and Technology, China Agricultural University)
Kong, Xianghao (College of Animal Science and Technology, Hebei North University)
Zhang, Wei (College of Animal Science and Technology, China Agricultural University)
Jia, Zhihai (College of Animal Science and Technology, China Agricultural University)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.20, no.10, 2007 , pp. 1496-1502 More about this Journal
Abstract
The roles of melatonin in the control of deiodinase (MD) activity in cashmere goat skin and associated cashmere fibre growth were investigated. Eighteen half-sib Chinese Inner Mongolia cashmere wethers were allocated randomly to two groups (n = 9/group). One group was implanted subcutaneously with melatonin (2 mg/kg BW) at three 2-monthly intervals while the other group served as a control. All goats were maintained under natural photoperiodic conditions and were grazed on natural pasture. The plasma melatonin concentration showed a significant difference (p<0.01) between the implant group (M) and the control group (C) but plasma $T_4$ (or $T_3$) showed no significant difference (p>0.05). The monodeiodinase type II (MDII) activity in skin tended to increase gradually from the summer solstice to November. During July and August, the activity of MDII for the M group was higher (p<0.05) than that of the C group; also during this period, there was a significant positive correlation between MDII activity of skin and cashmere fibre growth rate. The monodeiodinase type III (MDIII) activity and the ratio of MDIII and MDII tended to decrease from the summer solstice to November. The ratio of MDIII and MDII for the M group was lower (p<0.05) than that of the C group in July and August. The cashmere fibre growth rate of the M group was significantly greater than that of the C group in July (p<0.01), August (p<0.001) and September (p<0.05). The cashmere fibre diameter and guard hair and body weight were not influenced (p>0.05) by melatonin implantation. The results demonstrate that melatonin plays an important role in the regulation of skin MD activity. Simultaneously, the cashmere fibre elongation stimulated by melatonin may result from enhanced MDII activity during a period of two months after melatonin treatment.
Keywords
Deiodinase; Melatonin; Goats; Cashmere Fibre; Thyroid Hormone;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
연도 인용수 순위
1 Wang, L. F., D. X. Lu, H. Z. Sun, X. Y. Zhao and D. San. 2006. Effects of photoperiod and melatonin on nitrogen partitioning and cashmere growth in Inner Mongolia White Cashmere Goats. Agric. Sci. Chin. 39:1004-1010 (Chinese).
2 Teh, T. H., Z. H. Jia, K. D. Odgen and G. I. Newton. 1991. The effects of photoperiod and melatonin implant on cashmere production. J. Anim. Sci. 69:496 (Abstr).
3 Dicks, P., A. J. F. Russel and G. A. Lincoln. 1994. The role of prolactin in the reactivation of hair follicles and the spring moult in goats. J. Endocr. 143:441-448.   DOI   ScienceOn
4 Dicks, P., A. J. F. Russel and G. A. Lincoln. 1995. The effect of melatonin implants administered from December until April, on plasma prolactin, triiodothyronine and thyroxine concentrations and on the timing of the spring moult in cashmere goats. Anim. Sci. 60:239-247.   DOI
5 Hans, W. and N. K. Duong. 2004. Effects of Ensiled Cassava Tops on Rumen Environment Parameters, Thyroid Gland Hormones and Liver Enzymes of Cows Fed Urea-treated Fresh Rice Straw. Asian-Aust. J. Anim. Sci. 17:936-941.   과학기술학회마을   DOI
6 Bai, J. Y., Q. Zhang, J. Q. Li, E. J. Dao and X. P. Jia. 2006. Estimates of Genetic Parameters and Genetic Trends for Production Traits of Inner Mongolian White Cashmere Goat. Asian-Aust. J. Anim. Sci. 19:13-18.   과학기술학회마을
7 Nixon, A. J., V. J. Choy, A. L. Parry and A. J. Pearson. 1993. Fiber growth initiation in hair follicles of goats treated with melatonin. J. Exp. Zool. 1:47-56.
8 Rajendran, D., A. K. Pattanaik, S. A. Khan and S. P. S. Bedi. 2001. Iodine Supplementation of Leucaena leucocephala Diet for Goats. II. Effects on Blood Metabolites and Thyroid Hormones. Asian-Aust. J. Anim. Sci. 14:791-796.   DOI
9 Rhind, S. M. and S. R. Mcmillen. 1995. Seasonal patterns of secondary fibre growth, moulting and hair follicle activity in Siberian and Icelandic${\times}$Scottish feral goats offered high and liw levels of dietary protein. Small Rumin. Res. 17:69-76.
10 Dicks, P., C. J. Morgan, P. J. Morgan, D. Kelly and L. M. Williams. 1996. The locanlisation and characterisation of insulin-like growth factor-I (IGF-I) receptors and the investigation of melatonin receptors on the hair follicles of seasonal and nonseasonal fibre-producing goats. J. Endocr. 151:55-63.   DOI   ScienceOn
11 Rhind, S. M. and C. E. Kyle. 2004b. Skin deiodinase profiles and associated patterns of hair follicle activity in cashmere goats of contrasting genotypes. Aust. J. Agric. Res. 55:443-448.   DOI   ScienceOn
12 Vanecek, J. 1998. Cellular Mechanisms of Melatonin Action. Physiol. Rev. 78:687-721.   DOI
13 Villar, D., S. R. McMillen, P. Dicks and M. Rhind. 1999. The effects of bovine somatotropin on hair follicle activity and cashmere fibre growth in goats. Aust. J. Agric. Res. 50:1365-1373.   DOI
14 Kloren, W. R. L., B. W. Norton and M. J. Waters. 1993. Fleece growth in Australian cashmere goats. III. The seasonal patterns of cashmere and hair growth, and association with growth hormone, prolactin and thyroxine in blood. Aust. J. Agric. Res. 44:1035-1050.   DOI   ScienceOn
15 Rhind, S. M., C. E. Kyle and E. I. Duff. 2004a. Effects of season and of manipulation of circulating prolactin concentrations on deiodinase activity in cashmere goat skin. Aust. J. Agric. Res. 55:211-221.   DOI   ScienceOn
16 Villar. D., F. Nicol, J. R. Arthur, P. Dicks, A. Cannavan, D. G. Kennedy and S. M. Rhind. 2000b. Type II and type III monodeiodinase activites in the skin of untreated and propylthiouracil-treated cashmere goats. Res. Vet. Sci. 68:119-123.   DOI   ScienceOn
17 Ibraheem, M., H. Galbraith, J. Scaife and S. Rwen. 1994. Growth of secondary hair follicles on the Cashmere goat in vitro and their response to prolactin and melatonin. J. Anat. 1:135-142.
18 Jia, Z. H., T. H. The and M. An. 1996. Effects of exogenous melatonin on the productivity of cashmere goats. International Academic Publishers, Vi International Conference on Goats. 2:890-893.
19 Santiago-Moreno, J., A. Lopez-Sebastian, A. Campoa, A. Gonzalez-Bulnes, R. Picazo and A. Gomez-Brunet. 2004. Effect of constant-release melatonin implants and prolonged exposure to a long day photoperiod on prolactin secretion and hair growth in mouflon (Ovis gmelini musimon). Dom. Anim. En. 26:303-314.   DOI   ScienceOn
20 Lohakare, J. D., A. K. Pattanaik and S. A. Khan. 2006. Effect of Dietary Protein Levels on the Performance, Nutrient Balances, Metabolic Profile and Thyroid Hormones of Crossbred Calves. Asian-Aust. J. Anim. Sci. 19:1588-1596.   과학기술학회마을   DOI
21 Santiago-Moreno, J., A. Gómez-Brunet, A. Gonzalez-Bulnes, A. Toledano-Díaz, B. Malpaux and A. López-Sebastiάn. 2005. Differences in reproductive pattern between wild and domestic rams are not associated with inter-specific annual variations in plasma prolactin and melatonin concentrations. Dom. Anim. En. 28:416-429.   DOI   ScienceOn
22 SAS. 1999. SAS/STAT User'guide, (Release 8.2). SAS Inst. Inc., Cary, NC.
23 Zhou, H. M., D. Allain, J. Q. Li, W. G. Zhang and X. C. Yu. 2003. Effects of non-genetic factors on production traits of Inner Mongolia cashmere goats in China. Small Rumin. Res. 47:85-89.   DOI   ScienceOn
24 Villar, D., S. R. McMillen, P. Dicks and S. M. Rhind. 2000a. The roles of thyroid hormones and prolactin in the control of fibre moult and associated changes in hair follicle activities in cashmere goats. Aust. J. Agric. Res. 51:407-414.   DOI   ScienceOn
25 Chen, S. L., M. H. Li, Y. J. Li, S. H. Zhao, C. Z. Yu, M. Yu, B. Fan and K. Li. 2001. RAPD Variation and Genetic Distances among Tibetan, Inner Mongolia and Liaoning Cashmere Goats Asian-Aust. J. Anim. Sci. 14:1520-1522.   DOI
26 Beckett, G. J. and J. R. Arthur. 1994. The iodothyronine deiodinases and 5'-deiodination. In: (Ed. M. C. Sheppard and P. M. Stewart). Bailliere's Clin. Endocr. Metab. 8:285-304.   DOI   ScienceOn