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http://dx.doi.org/10.5713/ajas.2006.1090

Global Histone H4 Acetylation of IGF1 and GH Genes in Lungs of Somatic Cell Cloned Calves  

Zhang, L. (National Laboratory for Agrobiotechnology, China Agricultural University)
Wang, S.H. (National Laboratory for Agrobiotechnology, China Agricultural University)
Fan, B.L. (National Laboratory for Agrobiotechnology, China Agricultural University)
Dai, Y.P. (National Laboratory for Agrobiotechnology, China Agricultural University)
Fei, J. (National Laboratory for Agrobiotechnology, China Agricultural University)
Li, N. (National Laboratory for Agrobiotechnology, China Agricultural University)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.19, no.8, 2006 , pp. 1090-1094 More about this Journal
Abstract
Histone acetylation modification is one key mechanism in the regulation of gene activation. In this study, we investigated the global levels of histone H4 acetylation of insulin like growth factor I (IGF1) and growth hormone (GH) genes in the lungs of two somatic cell cloned calves. Data showed the levels of histone H4 acetylation of IGF1 and GH genes vary widely within different gene regions, and, in almost all regions of the two genes, acetylation levels are lower in the aberrant clone than in the normal clone. Thus we suggest that inefficient epigenetic reprogramming in the clone may affect the balance between acetylation and deacetylation, which will affect normal growth and development. These findings will also have implications for improvement of cloning success rates.
Keywords
Histone H4 Acetylation; Somatic Cloned Calves; IGF1; GH; Lung;
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