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http://dx.doi.org/10.5713/ajas.2006.763

Association of MC4R Gene Polymorphisms with Growth and Body Composition Traits in Chicken  

Li, Chun-Yu (College of Animal Science and Technology, Northeast Agricultural University)
Li, Hui (College of Animal Science and Technology, Northeast Agricultural University)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.19, no.6, 2006 , pp. 763-768 More about this Journal
Abstract
Genetic and pharmacological studies in mice have demonstrated a complementary role for the melanocortin 4 receptor (MC4R) in the control of food intake, energy balance and body weight. This study was designed to investigate the associations of a MC4R gene polymorphism on chicken growth and body composition traits in broiler lines divergently selected for abdominal fat. A SNP (G54C) was found in CDS region of chicken MC4R gene. The analysis of the least squares and variance revealed a significant association between the G54C SNP and BW, CW and SL at 7 wk of age, and there were significant differences in different genotypes (p<0.05). The results from protein secondary structure prediction and tertiary structure prediction showed that it appeared a helix in $13^{th}$ amino acid and two strands at $14^{th}$ and $15^{th}$ amino acid in mutant protein, respectively. It maybe induce the change of the activity or function of MC4R gene in poultry.
Keywords
Melanocortin 4 Receptor; SNP; Body Weight; Body Composition; Chicken;
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