Browse > Article
http://dx.doi.org/10.5713/ajas.2006.224

Effects of Dietary Lycopene and Vitamin E on Egg Production, Antioxidant Status and Cholesterol Levels in Japanese Quail  

Sahin, N. (Veterinary Control and Research Institute)
Sahin, K. (Department of Animal Nutrition, Faculty of Veterinary Science)
Onderci, M. (Veterinary Control and Research Institute)
Karatepe, M. (Department of Biochemistry, Faculty of Science, Firat University)
Smith, M.O. (Department of Animal Science, The University of Tennessee)
Kucuk, O. (Karmanos Cancer Institute, Wayne State University)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.19, no.2, 2006 , pp. 224-230 More about this Journal
Abstract
Japanese Quails were used to evaluate the effects of dietary supplementation with vitamin E (dl-a-tocopheryl-acetate), lycopene, and their combination on egg production, egg quality, concentrations of malondialdehyde (MDA), vitamin E, A and cholesterol in serum and egg yolk. Quails (n = 120; 55 d old) were divided into four groups (n = 30/group) and fed a basal diet or the basal diet supplemented with lycopene (100 mg/kg diet), vitamin E (250 mg dl-${\alpha}$-tocopheryl-acetate/kg diet) or a combination of lycopene and vitamin E (100 mg/kg lycopene plus 250 mg dl-${\alpha}$-tocopheryl-acetate/kg diet). Vitamin E and lycopene did not affect (p>0.05) body weight, feed intake or egg weight. Egg production and Haugh unit were greater (p<0.05) in each supplemental group compared with the control group (p<0.05). Serum and liver MDA levels were decreased in supplemented groups compared with the control group. Separately or as a combination, supplemental lycopene and vitamin E increased serum and egg yolk vitamin E and A but decreased cholesterol concentrations (p<0.05). In general, when a significant effect was found for a parameter, the magnitude of the responses to vitamin and lycopene supplements was greatest with the combination of the lycopene and vitamin E, rather than that observed with each supplement separately. Results of the present study indicate that supplementing with a combination of dietary lycopene and vitamin E reduced serum and yolk cholesterol concentrations and improved antioxidant status.
Keywords
Lycopene; Vitamin E; Egg; MDA;
Citations & Related Records

Times Cited By Web Of Science : 17  (Related Records In Web of Science)
Times Cited By SCOPUS : 16
연도 인용수 순위
1 Agarwal, S. and A. V. Rao. 1998c. Tomato lycopene and lowdensity lipoprotein oxidation:a human dietary intervention study. Lipids 33:981-984   DOI   ScienceOn
2 Bartov, L. and M. Frigg. 1992. Effect of high concentrations of dietary vitamin E during various age periods on performance, plasma vitamin E and meat stability of broiler chicks at 7 weeks of age. Br. Poult. Sci. 33:393-402   DOI   ScienceOn
3 Cherian, G., F. H. Wolfe and J. S. Sim. 1996b. Dietary oils with added tocopherols: effects on egg or tissue tocopherols, fatty acids and oxidative stability. Poult. Sci. 75:423-431   DOI   ScienceOn
4 Grobas, S. 1997. Influencia de la nutricio'n sobre el toman o y la calidad interna del huevo. Doctoral Thesis. Universidad Polite'cnica de Madrid, Escuela Te'cnica Superior de Ingenieros Agro' nomos, Madrid, Spain
5 Meluzzi, A., N. Tallarico, G. Manfreda, F. Sirri and A. Franchini. 2000. Effect of dietary vitamin E on the quality of table eggs enriched with n-3 long chain fatty acids. Poult. Sci. 79:539-545   DOI
6 Nobile, S. and E. A. Irving. 1966. Relationship of $\alpha$-tocopherol in the feed to total tocopherol in the egg. Vet. Rec. 78:113-114
7 Rao, A. V. and S. Agarwal. 1999. Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: a review. Nutr. Res.19:305-323
8 Sasago, K., H. Kobayashi and T. Tsugo. 1974. Tocopherol content of egg yolk. J. Jap. Soc. Food Nutr. 27:147-151
9 Sahin, K. and O. Kucuk. 2001b. Effects of vitamin E and selenium on performance, digestibility of nutrients and carcass characteristics of Japanese quails reared under heat stress ($34^{\circ}C$). J. Anim. Physiol. A. Anim. Nutr. 85:342-348   DOI
10 Putnam, M. E. and N. Comben. 1987 Vitamin E. Vet Rec. 121:541-545
11 Gridley, G., J. K. Maclaughlin, G. Block, W.J. Blot, M. Gluch and J. Fraumeni. 1992. Vitamin supplement use and reduced risk of oral and pharyngeal cancer. Am. J. Epidemiol. 135:1083-1088   DOI
12 Berrio, L. P. and J. A. Hebert. 1990. The Effect of Adding Cholesterol to Laying Hen Diets as Powder or Predissolved in Fat. Poult. Sci. 69:972-976   DOI   ScienceOn
13 Chen, J. Y., J. D. Latshaw, H. O. Lee and D. B. Min. 1998. $\alpha$- Tocopherol content and oxidative stability of egg yolk as related to dietary $\alpha$-tocopherol. J. Food Sci. 63:919-922   DOI   ScienceOn
14 Frigg, M., C. C. Whitehead and S. Weber. 1992. Absence of effects of dietary $\alpha$-tocopherol on egg yolk pigmentation. Br. Poult. Sci. 33:247-353
15 McDowell, L. R. 1989. Vitamins in animal nutrition. comparative aspects to human nutrition. Vitamin C, A and E. (Ed. L. R. Mc Dowell) Academic Press London, pp. 93-131
16 Sahin, K., O. Kucuk, N. Sahin and M. Sari. 2002. Effects of vitamin C and vitamin E on ipid peroxidation status, some serum hormone, metabolite, and mineral concentrations of Japanese quails reared under heat stress ($34^{\circ}C$). Int. J. Vitamin Nutr. Res. 71:91-100
17 SAS. 1985. SAS User's Guide: Statistics. Version 5. SAS Institute, Inc., Cary, NC
18 Sunder, A. and G. Flachowsky. 2001. Influence of high vitamin E dosages on retinol and carotinoid concentration in body tissues and eggs of laying hens. Arch Tierernahr. 55:43-52   DOI   ScienceOn
19 Kucuk, O., F. Sarkar, Z. Djuric, W. Sakr, M. Pollak, F. Khachik, M. Banerjee, J. Bertram and D. P. Jr. Wood. 2002. Effects of lycopene supplementation in patients with localized prostate cancer. Exp. Biol. Med. 227:881-885   DOI
20 Leal, M., A. Shimada, F. Ruiz and E. G. Mejia. 1999. Effect of lycopene on lipid peroxidation and glutathione-dependent enzymes induced by T-2 toxin in vivo. Toxicol. Letters 109:1-10
21 Gallo-Torres, D. C. 1980. Absorption, blood transport and metabolism of vitamin E. In: A Comprehensive Treatise (Ed. L. J. Machlin). Marcel Dekker, New York, pp. 170-267
22 Ohkawa, H., N. Ohishi and K. Yagi. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:351-358   DOI   ScienceOn
23 Sahin, K., N. Sahin, M. Onderci, S. Yaralioglu and O. Kucuk. 2001. Protective role of supplemental vitamin E on lipid peroxidation, vitamins E, A and some mineral concentrations of broilers reared under heat stress. Vet. Med. Czech, 46:140-144   DOI
24 Sharoni, Y., E. Giron, M. Rise and J. Levy. 1997. Effects of lycopene-enriched tomato olerosin on 7, 12-dimethyl-benz [a] antracene-induced rat mammary tumors, Cancer Detect. Prev. 21:118-123
25 Dimascio, P., S. Kaiser and S. Sies. 1989. Lycopene as the most effective biologica carotenoid singlet oxygen quencher. Arch. Biochem. Biophys. 274:532-538   DOI   ScienceOn
26 Leeson, S., L. Caston and T. Maclaurin. 1998. Organoleptic evaluation of eggs produced by laying hens fed diets containing graded levels of flaxseed and vitamin E. Poult. Sci. 77:1436-1440   DOI
27 NRC. 1994. Nutrient Requirements of Poultry. 9th rev. ed. National Academy Press, Washington, DC
28 Buckley, D. J., P. A. Morrissey and J. I. Gray. .1995. Infuence of dietary vitamin E on the oxidative stability and quality of pig meat. J. Anim. Sci. 73:3122-3130   DOI
29 Diplock, A. T. 1991. Antioxidant nutrients and disease prevention: An overview. Am. J. Clin. Nutr. 53:189-193s
30 Flachowsky, G. 2000. Vitamin E-transfer from feed into pig tissues. J. Appl. Anim. Res. 17:69-80   DOI
31 Jain, C. K., S. Agarwal and A. V. Rao. 1999. The effect of dietary lycopene on bioavailability, tissue distribution, in-vivo antioxidant properties and colonic preneoplasia in rats. Nutr. Res. 19:1383-1391   DOI   ScienceOn
32 Rimm, E. B., M. J. Stampfer, A. Ascherio, E. Giovannucci, G. A. Colditz and W. C. Wittlet. 1993. Vitamin E consumption and risk of coronary disease in men. N. Engl. Med. 328:1450-1456   DOI   ScienceOn
33 Flachowsky, G., D. Engelman, A. Sunder, I. Halle and H. P. Sallmann. 2002. Eggs and poultry meat as tocopherol sources in dependence on tocopherol supplementation of poultry diets Food Research International 35:239-243   DOI   ScienceOn
34 Morrissey, P. A., D. J. Buckley, H. Sisk, P. B. Lynch and P. J. A. Sheehy. 1996. Uptake of $\alpha$-tocopherol in porcine plasma and tissues. Meat Sci. 44:275-382   DOI   ScienceOn
35 Stampfer, M. J., C. M. Hennekens, J. E. Manson, G. A. Colditz, B. Rosner and W. C. Willet. 1993. Vitamin E consumption and the risk of coronary disease in women. N. Engl. Med. 328:144-1449
36 AOAC. 1990. Official Methods of Analysis. 15th ed. Association of Official Analytical Chemists, Washington, DC
37 Haq, A. U., C. A. Bailey and A. Chinnah. 1996. Effect of betacarotene, carlthaxanthin, lutein, and vitamin E on neonatal immunity of chicks when supplemented in the broiler breeder diets. Poult. Sci. 75:1092-1097   DOI   ScienceOn
38 Kneckt, P. 1993. Human data on vitamin E in cancer. Pennington Cent. Nutr. (Vitamins and cancer prevention) 3:270-287
39 Cherian, G., F. H. Wolfe and J. S. Sim. 1996a. Feeding dietary oils with tocopherols. Effects on internal qualities of eggs during storage. J. Food Sci. 61:15-18   DOI
40 Combs, G. F. 1976. Differential effects of high dietary levels of vitamin A on the vitamin E-selenium nutrition of young and adult chickens. J. Nutr. 106:967-975   DOI
41 Gebert, S., R. Messikommer, H. P. Pfirter, G. Bee and C. Wenk. 1998. Dietary fats and vitamin E in diets for laying hens: effects on laying performance, storage stability and fatty acidcomposition of eggs. Archiv Geflulk. 62:214-222
42 Surai, P., I. Ionov, A. Buzhin and N. Buzhina. 1997. Vitamin E and egg quality. Pages 387-394 in Proceedings of the 7th European Symposium on the Quality of Eggs and Egg Products,Poznan, Poland, Zaklad Poligraficzny "Graf-Com," Poznan, Poland
43 Halliwell, B. and J. M. C. Gutteridge. 1999. Free radicals, other reactive species, and disease. In: (Ed. B. Halliwell, J. M. C. Gutteridge). Free Radicals in Biology and Medicine. Oxford, UK: Oxford University Press, 617-783
44 Janero, D. R. 1991. Therapeutical potential of vitamin E in the pathogenesis of spontaneous arteriosclerosis. Free Radic. Biol. 11:129-144   DOI   ScienceOn
45 Sahin, K. and O. Kucuk. 2001a. Effects of vitamin C and Vitamin E on performance, digestion of nutrients and carcass characteristics of Japanese quails reared under chronic heat stress ($34^{\circ}C$). J. Anim. Physiol. A. Anim. Nutr. 85:335-341   DOI
46 Puthpongsiriporn, U., S. E. Scheideler, J. L. Sell and M. M. Beck. 2001. Effects of vitamin E and C supplementation on performance, in vitro lymphocyte proliferation, and antioxidant status of laying hens during heat stress. Poult. Sci. 80:1190-1200   DOI
47 Wen, J., S. N. Mccarthy, F. M. J. Higgins, P. A. Morrissey, D. J. Buckley and P. J. Sheehy. 1997. Effect of dietary $\alpha$- tocopheryl-acetate on the uptake and distribution of $\alpha$- tocopherol oxidative stability of egg yolk as related to dietary $\alpha$-tocopherol. J. Food Sci. 63:919-922   DOI   ScienceOn
48 Angelo, A. S. T. 1992. Lipid oxidation in food. Washington DC:ACS Symp, Series 500, Am. Chem. Soc. Washington DC USA
49 Dju, M., M. L. Quaife and P. L. Harris. 1950. Utilization of pure $\alpha,\;\beta,\;\delta$-tocopherols by laying hens. Am. J. Physiol. 160:259-263
50 Eisen, E. J., B. B. Bohren and H. E. Mckean. 1962. The haugh unit as a measure of egg albumen quality. Poult. Sci. 41:1461-1468   DOI
51 Irie, T. and T. Seki. 2002. Retinoid composition and retinal localization in the eggs of teleost fishes. Comp. Biochem. Phiysiol. 131:209-215   DOI   ScienceOn
52 Jakobsen, K., S. K. Jensen and R. M. Engberg. 1997. Zur Bioverfu gbarkeit von zwei verschiedenen Vitamin E-Quellen bei Mastschweinen. Proc. Soc. Nutr. Physiol. 6:148-152
53 Kucuk, O., F. Sarkar, W. Sakr, Z. Djuric, F. Khachik, M. Pollak, J. Bertram, D. Grignon, M. Banerjee, J. Crissman, E. Pontes and D. P. Jr. Wood. 2001. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Cancer Epidemiol Biomarkers Prev. 10:861-868
54 Paran, E. and Y. Engelhard. 2001. Effect of tomato's lycopene on blood pressure, serum lipoproteins, plasma homocysteine and oxidative sress markers in grade i hypertensive patients. AJH-, 14:333-336
55 Ajuyah, A. O., R. T. Hardin and J. S. Sim. 1993. Effect of dietary full-fat flax seed with and without antioxidant on the fatty acid composition of major lipid classes of chicken meats. Poult. Sci. 72:125-136   DOI
56 Galobart, J. A., C. Barroeta, M. D. Baucells and F. Guardiola. 2001. Lipid oxidation in fresh and spray-dried eggs enriched with n-3 and n-6 polyunsaturated fatty acids during storage as affected by dietary vitamin E and canthaxanthin supplementation. Poult. Sci. 80:327-337   DOI
57 Sheehy, P. A., A. Morrissey and A. Flynn. 1991. Influence of dietary $\alpha$-tocopherol concentration in chick tissues. Br. Poult. Sci. 32:391-397   DOI   ScienceOn
58 Jiang, Y. H., R. B. Mcgeachin and C. A. Bailey. 1994. $\alpha$- Tocopherol, $\beta$-carotene, and retinol enrichment of chicken eggs. Poult. Sci. 73:1137-1143   DOI   ScienceOn
59 Leonhardt, M., S. Gerbert and C. Wenk. 1997. Vitamin E content of different animal products: Influence of animal nutrition. Z. Ernahrungswiss. 36:23-27
60 Marshal, A. C., A. R. Sams and M. E. Van Elswyk. 1994. Oxidative stability and sensory qualities of stored eggs from hens fed 1. 5% menhaden oil. J. Food Sci. 59:561-563   DOI   ScienceOn
61 Riemersma, R. A., D. A. Wood, C. C. Macintyre, R. A. Elton and F. Gey. 1991. Risk of angina pectoris and plasma concentra-tions of vitamins A, C and E and carotene. Lancet, 337:1-5   DOI   ScienceOn
62 Surai, P., I. Ionov, A. Buzhin and N. Buzhina. 1995. Vitamin E and egg quality. Pages 387-394 in Proceedings of the 6th European Symposium on the quality of eggs and egg products (Ed. R. Cepero), Zaragoza, Spain
63 Flachowsky, G. and A. Berk. 1998. Carry over of additional vitamin E amounts from feed into food of animal origin. In: Proc. 3rd Karlsruhe Nutrition Symposium European research towards safer and better food. 18-20 October, 1998 (Part 2, pp. 135-142)
64 Naber, E. C.1993. Modifying vitamin composition of eggs: A review. J. Appl. Poult. Res. 2:385-393   DOI
65 Chan, K. M. and E. A. Decker. 1994. Endogenous skeletal muscle antioxidants. Crit. Rev. Food Sci. Nutr. 34:403-426   DOI   ScienceOn
66 Sunder, A., G. Richter and G. Flachowsky. 1997. Influence of different concentrations of vitamin E in the feed of laying hens on the vitamin E-transfer into the egg. Proc. Soc. Nutr. Physiol. 6:114-15
67 Wenk, C., M. Leonhardt and M. R. L. Scheeder. 2000. Monogastricnutrition and potential for improving muscle quality. Pages 199-228 in Antioxidants in Muscle Foods: Nutritional Strategies to Improve Quality. (Ed. E. A. Decker, C. Faustman,and C. J. Lopez-Bote). Wiley Interscience, New York
68 Halliwell, B. and J. M. C. Gutteridge. 1989. Free Radicals in Biology and Medicine. 2nd ed. Oxford University Press, New York, NY
69 Rao, A. V. and H. Shen. 2002. Effect of low dose lycopene intake or lycopene bioavailability and oxidative stres. Nutr. Res. 22:1125-1131   DOI   ScienceOn
70 Bollengier-Lee, S., M. A. Mitchell, D. B. Utomo, P. E. V. Williams and C. C. Whitehead. 1998. Influence of high dietary vitamin e supplementation on egg production and plasma characteristics in hens subjected to heat stress. Br. Poult. Sci. 39:106-112   DOI
71 Morrissey, P. A., S. Brandon, D. J. Buckley, P. J. A . Sheehy and M. Frigg. 1997. Tissue content of $\alpha$-tocopherol and oxidative stability of broilers receiving dietary $\alpha$-tocopheryl acetate supplement for various periods pre-slaughter. Br. Poult. Sci. 38:84-88   DOI   ScienceOn
72 Bartov, I., P. Budowski and S. Bornstein. 1965. The relationship between $\alpha$-tocopherol content of the breeder diet and that of the newly hatched chick. Poult. Sci. 44:1489-1494   DOI
73 Guo, Y., Q. Tang, J. Yuan and Z. Jiang. 2001. Effects of supplementation with Vitamin E on the performance and the tissue peroxidation of broiler chicks and the stability of thigh meat against oxidative deterioration. Anim. Feed Sci. Technol. 89:165-173   DOI   ScienceOn
74 Engelmann, D. 1999. Ein uss sehr hoher vitamin E-Gaben auf leistung und physiologische parameter bei legehennen. Dissertation Tiera rztl. Hochschule Hannover
75 Kucuk, O., F. Sarkar, W. Sakr, F. Khachik, Z. Djuric, M. Banerjee, M. Pollak, J. Bertram and D. P. Jr. Wood. 2002. Lycopene in the treatment of prostate cancer. Pure Appl. Chem. 74:1443-1450   DOI   ScienceOn
76 Kucuk, O. 2002. Chemoprevention of prostate cancer. Cancer Metast Rev. 21:111-124   DOI   ScienceOn
77 Surai, P. F., R. C. Noble and B. K. Speake. 1996. Tissue specific differences in antioxidant distrubition and susceptibility to lipid peroxidation during development of the chick embryo. Biochem. Biophys. Acta. 1304:1-10   DOI   ScienceOn
78 Eriksson, C. E. 1987. Oxidation of lipids in food system. Pages 207-217 in Autoxidation of Unsaturated Lipid. Academic Press, London