Browse > Article
http://dx.doi.org/10.5713/ajas.2006.1529

Leptin Polymorphisms Associated with Carcass Traits of Meat in Korean Cattle  

Cheong, Hyun Sub (Department of Genetic Epidemiology, SNP Genetics, Inc.)
Yoon, Du-Hak (National Livestock Research Institute, RDA)
Kim, Lyoung Hyo (Department of Genetic Epidemiology, SNP Genetics, Inc.)
Park, Byung Lae (Department of Genetic Epidemiology, SNP Genetics, Inc.)
Chung, Eui Ryong (Department of Biotechnology, Sangi University)
Lee, Han Ju (National Livestock Research Institute, RDA)
Cheong, Il-Cheong (National Livestock Research Institute, RDA)
Oh, Sung-Jong (National Livestock Research Institute, RDA)
Shin, Hyoung Doo (Department of Genetic Epidemiology, SNP Genetics, Inc.)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.19, no.11, 2006 , pp. 1529-1535 More about this Journal
Abstract
Leptin has been investigated as a candidate gene for fat characteristics in beef cattle. Previously, we have reported 57 sequence variants discovered in Korean cattle (Bos Taurus coreanae). In this study, we examined the association between polymorphisms of leptin and carcass traits (cold carcass weight (CWT) and marbling score (Marb)) in Korean cattle. Among 57 polymorphisms, 11 common polymorphic sites were genotyped in our beef cattle (n = 437). Statistical analysis revealed that one single nucleotide polymorphism in coding exon (c.+411T>C (A137A)) showed a significant association with the yield trait, CWT. The C-bearing genotypes (CC or CT) of c.+411T>C (A137A) showed the higher CWT (p = 0.006). c.+150C>G (S50S) also showed a significant association with the quality trait, Marb (p = 0.01). Our findings suggest that polymorphisms in leptin might be one of the important genetic factors that influence carcass yield and quality in beef cattle, especially in CWT and Marb.
Keywords
Leptin; Cold Carcass Weight; Marbling Score; Polymorphism;
Citations & Related Records

Times Cited By Web Of Science : 5  (Related Records In Web of Science)
Times Cited By SCOPUS : 5
연도 인용수 순위
1 Ahima, R. S. and J. S. Flier. 2000. Adipose tissue as an endocrine organ. Trends. Endocrinol. Metab. 11:327-332   DOI   ScienceOn
2 APGS. 1995. Report of business for animal products grading. Animal products grading system, National Livestock Cooperatives Federation, Korea
3 Buchanan, F. C., C. J. Fitzsimmons, A. G. Van Kessel, T. D. Thue, D. C. Winkelman-Sim and S. M. Schmutz. 2002. Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mrna levels. Genet. Sel. Evol. 34:105-116   DOI   ScienceOn
4 Halaas, J. L., C. Boozer, J. Blair-West, N. Fidahusein, D. A. Denton and J. M. Friedman. 1997. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. USA 94:8878-8883
5 Jequier, E. 2002. Leptin signaling, adiposity, and energy balance. Ann. NY. Acad. Sci. 967:379-388
6 Montague, C. T., I. S. Farooqi, J. P. Whitehead, M. A. Soos, H. Rau, N. J. Wareham, C. P. Sewter, J. E. Digby, S. N. Mohammed, J. A. Hurst, C. H. Cheetham, A. R. Earley, A. H. Barnett, J. B. Prins and S. O'Rahilly. 1997. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387:903-908   DOI   ScienceOn
7 Palkovits, M. 2003. Hypothalamic regulation of food intake. Ideggyogy. Sz. 56:288-302
8 Vreeland, W. N., R. J. Meagher and A. E. Barron. 2002. Multiplexed, high-throughput genotyping by single-base extension and end-labeled free-solution electrophoresis. Anal. Chem. 74:4328-4333   DOI   ScienceOn
9 Zuker, M. 2003. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31:3406-3415   DOI   ScienceOn
10 Halaas, J. L., K. S. Gajiwala, M. Maffei, S. L. Cohen, B. T. Chait, D. Rabinowitz, R. L. Lallone, S. K. Burley and J. M. Friedman. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene. Sci. 269:543-546   DOI
11 Ji, S., G. M. Willis, R. R. Scott and M. E. Spurlock. 1998. Partial cloning and expression of the bovine leptin gene. Anim. Biotechnol. 9:1-14   DOI   ScienceOn
12 Fitzsimmons, C. J., S. M. Schmutz, R. D. Bergen and J. J. McKinnon. 1998. A potential association between the bm 1500 microsatellite and fat deposition in beef cattle. Mamm. Genome. 9:432-434   DOI
13 Kadokawa, H., D. Blache, Y. Yamada and G. B. Martin. 2000. Relationships between changes in plasma concentrations of leptin before and after parturition and the timing of first postpartum ovulation in high-producing holstein dairy cows. Reprod. Fertil. Dev. 12:405-411   DOI   ScienceOn
14 Prins, J. B. and S. O'Rahilly. 1997. Regulation of adipose cell number in man. Clin. Sci. (Lond) 92:3-11   DOI
15 Yoon, D. H., B. H. Cho, B. L. Park, Y. H. Choi, H. S. Chung, H. K. Lee, E. R. Chung, S. J. Oh, I. C. Cheong and H. D. Shin. 2005. The highly polymorphic bovine leptin gene. Asian-Aust. J. Anim. Sci. 18:1548-1551
16 Konfortov, B. A., V. E. Licence and J. R. Miller. 1999. Resequencing of DNA from a diverse panel of cattle reveals a high level of polymorphism in both intron and exon. Mamm. Genome. 10:1142-1145   DOI   ScienceOn
17 Chung, E. R. and W. T. Kim. 2005. Association of SNP marker in IGF-I and MYF5 candidate genes with growth traits in Korean cattle. Asian-Aust. J. Anim. Sci. 18:1061-1065   DOI
18 Clement, K., C. Vaisse, N. Lahlou, S. Cabrol, V. Pelloux, D. Cassuto, M. Gourmelen, C. Dina, J. Chambaz, J. M. Lacorte, A. Basdevant, P. Bougneres, Y. Lebouc, P. Froguel and B. Guy-Grand. 1998. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392:398-401   DOI   ScienceOn
19 Hedrick, P. W. 1987. Gametic disequilibrium measures: Proceed with caution. Genet. 117:331-341
20 Lagonigro, R., P. Wiener, F. Pilla, J. A. Woolliams and J. L. Williams. 2003. A new mutation in the coding region of the bovine leptin gene associated with feed intake. Anim. Genet. 34:371-374   DOI   ScienceOn
21 Block, S. S., W. R. Butler, R. A. Ehrhardt, A. W. Bell, M. E. Van Amburgh and Y. R. Boisclair. 2001. Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance. J. Endocrinol. 171:339-348   DOI   ScienceOn
22 Wheeler, T. L., L. V. Cundiff and R. M. Koch. 1994. Effect of marbling degree on beef palatability in bos taurus and bos indicus cattle. J. Anim. Sci. 72:3145-3151
23 Geary, T. W., E. L. McFadin, M. D. MacNeil, E. E. Grings, R. E. Short, R. N. Funston and D. H. Keisler. 2003. Leptin as a predictor of carcass composition in beef cattle. J. Anim. Sci. 81:1-8
24 Reseland, J. E., K. Hollung and C. A. Drevon. 1999. Leptin-a fatty tissue hormone with many functions. Tidsskr. Nor. Laegeforen. 119:2024-2027
25 Stephens, M., N. J. Smith and P. Donnelly. 2001. A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68:978-989   DOI   ScienceOn
26 Wilusz, C. J., M. Wormington and S. W. Peltz. 2001. The cap-totail guide to mrna turnover. Nat. Rev. Mol. Cell. Biol. 2:237-246   DOI   ScienceOn
27 Baik, D. H., M. A. Hoque and H. S. Choe. 2002. Estimation of genetic and environmental paramenters of carcass traits in Hanwoo (Korean Native Cattle) populations. Asian-Aust. J. Anim. Sci. 15:1523-1526   DOI
28 Buchanan, F. C., A. G. Van Kessel, C. Waldner, D. A. Christensen, B. Laarveld and S. M. Schmutz. 2003. Hot topic: An association between a leptin single nucleotide polymorphism and milk and protein yield. J. Dairy Sci. 86:3164-3166   DOI   ScienceOn
29 Considine, R. V. 1997. Weight regulation, leptin and growth hormone. Horm. Res. 48 Suppl 5:116-121
30 Nyholt, D. R. 2005. Evaluation of nyholt's procedure for multiple testing correction - author's reply. Hum. Hered. 60:61-62   DOI   ScienceOn
31 Pelleymounter, M. A., M. J. Cullen, M. B. Baker, R. Hecht, D. Winters, T. Boone and F. Collins. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Sci. 269:540-543   DOI
32 Stone, R. T., S. M. Kappes and C. W. Beattie. 1996. The bovine homolog of the obese gene maps to chromosome 4. Mamm. Genome. 7:399-400   DOI
33 Kim, S. and N. Moustaid-Moussa. 2000. Secretory, endocrine and autocrine/paracrine function of the adipocyte. J. Nutr. 130:3110S-3115S   DOI
34 Santos-Alvarez, J., R. Goberna and V. Sanchez-Margalet. 1999. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell. Immunol. 194:6-11   DOI   ScienceOn
35 Soukas, A., P. Cohen, N. D. Socci and J. M. Friedman. 2000. Leptin-specific patterns of gene expression in white adipose tissue. Genes. Dev. 14:963-980
36 Friedman, J. M. 1998. Leptin, leptin receptors, and the control of body weight. Nutr. Rev. 56:s38-46; discussion s54-75