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http://dx.doi.org/10.5392/IJoC.2012.8.4.064

Protective effect of Tranilast on radiation-induced heart fibrosis in C57BL/6 mouse  

Moon, Seongkwon (Radiation Oncology, College of Medicine, Soonchunhyang University Bucheon Hospital)
Publication Information
International Journal of Contents / v.8, no.4, 2012 , pp. 64-69 More about this Journal
Abstract
The heart is a major dose-limiting organ for radiotherapy of cancer in the thoracic region. The purpose of this study was to examine the protective effect of tranilast on the radiation-induced heart fibrosis model using the C57BL/6 murine strain. A significant reduction in the expression of TGF-${\beta}1$, collagen type I and collagen type III was observed in the radiation plus tranilast group. The authors also suggest the use of tranilast in a clinical trial for the prevention of radiation-induced heart fibrosis.
Keywords
Heart Fibrosis; Radiation; Tranilast;
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1 L.F. Fajardo and J.R. Stewart, "Experimental radiationinduced heart disease," Light microscopic studies, Am J Pathol, vol. 59, no. 2, Feb. 1970, pp. 299-316.
2 B. Hocher, M. Godes, J. Oliver, J. Weil, T. Eschenhagen, and T. Slowinski, "Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension," J Hypertens, vol. 20, no. 4, Oct. 2002, pp. 745-751.   DOI   ScienceOn
3 A. Chikaraishi, J. Hirahashi, O. Takase, T. Marumo, K. Hishikawa, and M. Hayashi, "Tranilast inhibits interleukin-$1{\beta}$-induced monocyte chemoattractant protein-1 expression in rat mesangial cells," Eur J Pharmacol, vol. 427, no. 2, Dec. 2001, pp. 151-158.   DOI   ScienceOn
4 G. Gagliardi, I. Lax, LE. Rutqvist. " Partial irradiation of the heart,"Semin Radiat Oncol, vol. 11, no. 3, Jul. 2001, pp. 224-233.   DOI   ScienceOn
5 JR. Stewart, LF. Fajardo, SM. Gillette, et al, "Radiation injury to the heart," Int J Radiat Oncol Biol Phys, vol. 31, no. 5, Mar. 1995, pp. 1205-1211.   DOI   ScienceOn
6 J.R. Stewart, K.E. Cohn, L.F. Fajardo, W. Hanock, and H.S. Kaplan, "Radiation-induced heart disease. A study of twenty-five patients," Radiology, vol. 89, no. 2, Aug. 1967, pp. 302-310.   DOI
7 J.R. Stewart, L.F. Fajardo, K.E. Cohn, and V. Page, "Experimental radiation-induced heart disease in rabbits," Radiology, vol. 91, no. 4, Oct. 1968, pp. 814-817.   DOI
8 L.F. Fajardo, J.R. Stewart, and K.E. Cohn, "Morphology of radiation-induced heart disease, " Arch Pathol, vol. 86, no. 5, Nov. 1968, pp. 512-519.
9 J.R. Stewart and L.F. Fajardo, "Radiation-induced heart disease, " Prog Cardiovasc Dis, vol. 27, no. 3, May. 1984, pp. 173-179
10 D.P. Nelson, E. Stetser, D.G. Hall, S.M. Schwartz, T. Hewitt, and R. Klevisky, "Proinflammatory consequences of transgenic fas ligand expression in the heart," J Clin Invest, vol. 105, no. 9, May. 2000, pp. 1199-1208.   DOI   ScienceOn
11 Y. Sun, J.Q. Zhang, J. Zhang, and S. Lamparter, "Cardiac remodeling by fibrous tissue after infarction in rats, " J Lab Clin Med, vol. 135, no. 4, Apr. 2000, pp. 316-323.   DOI   ScienceOn
12 F.C. Luft, E. Mervaala, D.N. Muller, V. Gross, F. Schmidt, and J.K. Park, "Hypertension-induced endorgan damage: A new transgenic approach to an old problem, " Hypertension, vol. 33, no. 1, Jan. 1999, pp. 212-218.   DOI   ScienceOn
13 Y.M. Pinto, S.J. Pinto-Sietsma, T. Philipp, S. Engler, P. Kobmehl, and B. Hocher, "Reduction in left ventricular messenger RNA for transforming growth factor beta (1) attenuates left ventricular fibrosis and improves survival without lowering blood pressure in the hypertensive TGR (mRen2) 27 Rat," Hypertension, vol. 36, no. 5, May. 2000, pp. 747-754.   DOI   ScienceOn
14 L.F. Fajardo and J.R. Stewart, "Capillary injury preceding radiation-induced myocardial fibrosis," Radiology, vol. 101, no. 2, Sep. 1971, pp. 429-433.   DOI
15 S. Misfsud, D.J. Kelly, Q. W, Y. Zhang, C.A. Pollock, J.L. Wilkinson-Berka, et al. "Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy, " Nephron Physiol, vol. 95, no. 4, Jan. 2003, pp. 83-891.   DOI   ScienceOn
16 H.A. Lehr, D.A. Mankoff, D. Corwin, G. Santeusanio, and A.M. Gown, "Application of Photoshop-based image analysis to quantification of hormone receptor expression in breast cancer, " J Histochem Cytochem , vol. 45, no. 11, Feb. 1997, pp.1559-1665.   DOI
17 H.A. Lehr, C.M. van der Loss, P. Teeling, and A.M. Gown, "Complete chromogen separation and analysis in double immunohistochemical stains using Photoshopbased image analysis," J Histochem Cytochem, 1999, vol. 47, no. 1, Aug. 1999, pp. 119-125.   DOI   ScienceOn
18 L.F. Fajardo and J.R. Stewart, "Pathogenesis of radiationinduced myocardial fibrosis," Invest, vol. 29, no. 12, Oct. 1973, pp. 244-257.
19 H.P. Rodermann and M. Bamberg, "Cellular basis of radiation-induced fibrosis," Radiotherapy and Oncology, vol. 35, no. 2, Dec. 1995, pp. 83-90.   DOI   ScienceOn
20 C.M. Overall, J.L. Wrana, and J. Sodek, "Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-$\beta$," J Biol Chem, vol. 264, no. 3, Nov. 1989, pp. 1860-1869.
21 J. Varga, J. Rosenbloem, and S.A. Jimenez, "Transforming growth factor-$\beta$ (TGF-$\beta$) caused a persistent increase in steady state amounts of type I and type III collagen and fibronectin mRNAs in normal human fibroblasts," Biochem J, vol. 247, no. 3, May. 1987, pp. 597-604.   DOI