Browse > Article
http://dx.doi.org/10.31616/asj.2018.12.6.1078

Novel Hybrid Hydroxyapatite Spacers Ensure Sufficient Bone Bonding in Cervical Laminoplasty  

Tanaka, Nobuhiro (Department of Orthopaedic Surgery, Hiroshima General Hospital)
Nakanishi, Kazuyoshi (Department of Orthopaedic Surgery, Institute School of Biomedical Sciences, Hiroshima University)
Kamei, Naosuke (Department of Orthopaedic Surgery, Institute School of Biomedical Sciences, Hiroshima University)
Nakamae, Toshio (Department of Orthopaedic Surgery, Institute School of Biomedical Sciences, Hiroshima University)
Kotaka, Shinji (Department of Orthopaedic Surgery, Institute School of Biomedical Sciences, Hiroshima University)
Fujimoto, Yoshinori (Department of Orthopaedic Surgery, Hiroshima General Hospital)
Ochi, Mitsuo (Department of Orthopaedic Surgery, Institute School of Biomedical Sciences, Hiroshima University)
Adachi, Nobuo (Department of Orthopaedic Surgery, Institute School of Biomedical Sciences, Hiroshima University)
Publication Information
Asian Spine Journal / v.12, no.6, 2018 , pp. 1078-1084 More about this Journal
Abstract
Study Design: Prospective observational study. Purpose: This prospective analysis aimed to evaluate the efficacy and bone-bonding rate of hybrid hydroxyapatite (HA) spacers in expansive laminoplasty. Overview of Literature: Various types of spacers or plates have been developed for expansive laminoplasty. Methods: Expansive open-door laminoplasty was performed in 146 patients with cervical myelopathy; 450 hybrid HA spacers and 41 autogenous bone spacers harvested from the spinous processes were grafted into the opened side of each lamina. The patients were followed up using computed tomography (CT), and their bone-bonding rates for hybrid HA and autogenous spacers, bone-fusion rates of the hinges of the laminae, and complications associated with the implants were then examined. Results: Clinical symptoms significantly improved in all patients, and no major complications related to the procedure were noted. The hybrid HA spacers exhibited sufficient bone bonding on postoperative CT. The hinges completely fused in over 95% patients within 1 year of the procedure. Only 4 spacers (0.9%) developed lamina sinking, and most expanded laminae maintained their positions without sinking or floating throughout the follow-up period. Conclusions: Hybrid HA spacers contributed to high bone-fusion rates of the spacers and hinges of the laminae, and no complications were associated with their use. Cervical laminoplasty with these spacers is safe and simple, and it yields sufficient fixation strength while ensuring sufficient bone bonding during the immediate postoperative period.
Keywords
Cervical vertebrae; Laminoplasty; Myelopathy compressive; Calcium hydroxyapatite;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Hase H, Watanabe T, Hirasawa Y, et al. Bilateral open laminoplasty using ceramic laminas for cervical myelopathy. Spine (Phila Pa 1976) 1991;16:1269-76.   DOI
2 Hirabayashi S, Kumano K. Contact of hydroxyapatite spacers with split spinous processes in double-door laminoplasty for cervical myelopathy. J Orthop Sci 1999;4:264-8.   DOI
3 Koshu K, Tominaga T, Yoshimoto T. Spinous process-splitting laminoplasty with an extended foraminotomy for cervical myelopathy. Neurosurgery 1995;37:430-4.   DOI
4 Nakano K, Harata S, Suetsuna F, Araki T, Itoh J. Spinous process-splitting laminoplasty using hydroxyapatite spinous process spacer. Spine (Phila Pa 1976) 1992;17(3 Suppl):S41-3.   DOI
5 Goto T, Ohata K, Takami T, et al. Hydroxyapatite laminar spacers and titanium miniplates in cervical laminoplasty. J Neurosurg 2002;97(3 Suppl):323-9.
6 Park AE, Heller JG. Cervical laminoplasty: use of a novel titanium plate to maintain canal expansion: surgical technique. J Spinal Disord Tech 2004;17:265-71.   DOI
7 Tanaka N, Nakanishi K, Fujimoto Y, et al. Expansive laminoplasty for cervical myelopathy with interconnected porous calcium hydroxyapatite ceramic spacers: comparison with autogenous bone spacers. J Spinal Disord Tech 2008;21:547-52.   DOI
8 Park YK, Lee DY, Hur JW, Moon HJ. Delayed hinge fracture after plate-augmented, cervical open-door laminoplasty and its clinical significance. Spine J 2014;14:1205-13.   DOI
9 Adachi N, Ochi M, Deie M, Ito Y. Transplant of mesenchymal stem cells and hydroxyapatite ceramics to treat severe osteochondral damage after septic arthritis of the knee. J Rheumatol 2005;32:1615-8.
10 Ito Y, Tanaka N, Fujimoto Y, et al. Bone formation using novel interconnected porous calcium hydroxyapatite ceramic hybridized with cultured marrow stromal stem cells derived from Green rat. J Biomed Mater Res A 2004;69:454-61.
11 Nakasa T, Ishida O, Sunagawa T, et al. Prefabrication of vascularized bone graft using a combination of fibroblast growth factor-2 and vascular bundle implantation into a novel interconnected porous calcium hydroxyapatite ceramic. J Biomed Mater Res A 2005;75:350-5.
12 Tamai N, Myoui A, Tomita T, et al. Novel hydroxyapatite ceramics with an interconnective porous structure exhibit superior osteoconduction in vivo. J Biomed Mater Res 2002;59:110-7.   DOI
13 Yoshikawa H, Myoui A. Bone tissue engineering with porous hydroxyapatite ceramics. J Artif Organs 2005;8:131-6.   DOI
14 Satomi K, Ogawa J, Ishii Y, Hirabayashi K. Shortterm complications and long-term results of expansive open-door laminoplasty for cervical stenotic myelopathy. Spine J 2001;1:26-30.   DOI
15 Hirabayashi K, Miyakawa J, Satomi K, Maruyama T, Wakano K. Operative results and postoperative progression of ossification among patients with ossification of cervical posterior longitudinal ligament. Spine (Phila Pa 1976) 1981;6:354-64.   DOI
16 Wang JM, Roh KJ, Kim DJ, Kim DW. A new method of stabilising the elevated laminae in open-door laminoplasty using an anchor system. J Bone Joint Surg Br 1998;80:1005-8.   DOI
17 Lee JY, Hanks SE, Oxner W, Tannoury C, Donaldson WF 3rd, Kang JD. Use of small suture anchors in cervical laminoplasty to maintain canal expansion: a technical note. J Spinal Disord Tech 2007;20:33-5.   DOI
18 Lee S, Chung CK, Kim CH. Risk factor analysis of hinge fusion failure after plate-only open-door laminoplasty. Global Spine J 2015;5:9-16.   DOI