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Administration of Agonistic Anti-4-1BB Monoclonal Antibody Inhibits Melanoma Metastasis Via IFN-${\gamma}$ Production  

Ju, Seong-A (Immunomodulation Research Center, University of Ulsan)
Lee, Sang-Chul (Immunomodulation Research Center, University of Ulsan)
Seok, Moon-Hong (Institute of Basic Sciences, Kyungpook National University)
Kim, Byung-Sam (Immunomodulation Research Center, University of Ulsan)
Publication Information
Animal cells and systems / v.8, no.2, 2004 , pp. 117-123 More about this Journal
Abstract
The purpose of this study was to analyze inhibitory effects of anti-4-1BB monoclonal antibody on melanoma metastasis The 4-1BB (CD137) T cell molecule is a member of the TNF receptor family and its activation by either 4-1BB ligand or antibody induces T cell activation and growth. In the present study, administration of anti-4-1BB mAb induced inhibition of melanoma metastasis. Agonistic anti-4-1BB mAb induced not only CD$8^+$4-1BBT cells but also CD$8^+$IFN-${\gamma}$$^{+}$ T cell population. In the presence of anti-CD3 antibody, lymphocytes produced high levels of IFN-${\gamma}$ and low levels of IL-4 in anti-4-1BB mAb treated group. Exposure of melanoma cells to IFN-${\gamma}$ induced expression of MHC-I molecules. Thus, the increase in number of CD$8^+$T cells and enhanced MHC-I expression on B16F10 cells by augmented IFN-${\gamma}$ production in response to anti-4-1BB mAb may result in suppression of tumor growth and metastasis.s.
Keywords
4-1 BB; IFN-${\gamma}$;
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