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Overexpression of SRG3/SW13 Protein Disrupts the Cell Cycle Progression in Mature T Cells and Yeast  

Jeon, Sung-Ho (Department of Microbiology, Mount Sinai School of Medicine, New York)
Choi, Young-Il (School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University and International Vaccine Institute)
Seong, Rho-Hyun (School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University and International Vaccine Institute)
Publication Information
Animal cells and systems / v.6, no.4, 2002 , pp. 335-339 More about this Journal
Abstract
Mouse T cells overexpressing the SRG3 protein displayed morphological changes; the cells were enlarged and their shapes were irregular compared to the normal parental cells. In addition, growth rate of the cells was dramatically reduced and their DNA contents were increased. The increased DNA contents were due to an increase in number of chromosomes in these cells. We have observed similar results in S. cerevisiae cells overex-pressing the yeast SWI3 protein. Yeast cells overexpressing SWI3 protein These results suggest that the SRG3/SWI3 protein plays an important role in cell growth and cell cycle progression.
Keywords
SRG3; SWI3; Polyploidy; Cell cycle; T cell; Yeast;
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