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http://dx.doi.org/10.14348/molcells.2019.0077

Non-Coding RNAs in Caenorhabditis elegans Aging  

Kim, Sieun S. (Department of Life Sciences, Pohang University of Science and Technology)
Lee, Seung-Jae V. (Department of Biological Sciences, Korea Advanced Institute of Science and Technology)
Publication Information
Molecules and Cells / v.42, no.5, 2019 , pp. 379-385 More about this Journal
Abstract
Non-coding RNAs (ncRNAs) comprise various RNA species, including small ncRNAs and long ncRNAs (lncRNAs). ncRNAs regulate various cellular processes, including transcription and translation of target messenger RNAs. Recent studies also indicate that ncRNAs affect organismal aging and conversely aging influences ncRNA levels. In this review, we discuss our current understanding of the roles of ncRNAs in aging and longevity, focusing on recent advances using the roundworm Caenorhabditis elegans. Expression of various ncRNAs, including microRNA (miRNA), tRNA-derived small RNA (tsRNA), ribosomal RNA (rRNA), PIWI-interacting RNA (piRNA), circular RNA (circRNA), and lncRNA, is altered during aging in C. elegans. Genetic modulation of specific ncRNAs affects longevity and aging rates by modulating established aging-regulating protein factors. Because many aging-regulating mechanisms in C. elegans are evolutionarily conserved, these studies will provide key information regarding how ncRNAs modulate aging and lifespan in complex organisms, including mammals.
Keywords
aging; Caenorhabditis elegans; lifespan; non-coding RNA; small RNA;
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