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http://dx.doi.org/10.14348/molcells.2019.2431

Microbial Colonization at Early Life Promotes the Development of Diet-Induced CD8αβ Intraepithelial T Cells  

Jung, Jisun (Academy of Immunology and Microbiology, Institute for Basic Science (IBS))
Surh, Charles D. (Academy of Immunology and Microbiology, Institute for Basic Science (IBS))
Lee, You Jeong (Academy of Immunology and Microbiology, Institute for Basic Science (IBS))
Publication Information
Molecules and Cells / v.42, no.4, 2019 , pp. 313-320 More about this Journal
Abstract
Intraepithelial lymphocytes (IELs) develop through the continuous interaction with intestinal antigens such as commensal microbiome and diet. However, their respective roles and mutual interactions in the development of IELs are largely unknown. Here, we showed that dietary antigens regulate the development of the majority of $CD8{\alpha}{\beta}$ IELs in the small intestine and the absence of commensal microbiota particularly during the weaning period, delay the development of IELs. When we tested specific dietary components, such as wheat or combined corn, soybean and yeast, they were dependent on commensal bacteria for the timely development of diet-induced $CD8{\alpha}{\beta}$ IELs. In addition, supplementation of intestinal antigens later in life was inefficient for the full induction of $CD8{\alpha}{\beta}$ IELs. Overall, our findings suggest that early exposure to commensal bacteria is important for the proper development of dietary antigen-dependent immune repertoire in the gut.
Keywords
antigen free; dietary antigen; germ free; intraepithelial T cells; microbiota;
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