1 |
Huber, A.H., and Weis, W.I. (2001). The structure of the -catenin/Ecadherin complex and the molecular basis of diverse ligand recognition by -catenin. Cell 105, 391-402.
DOI
|
2 |
Hur, J., and Jeong, S. (2013). Multitasking -catenin: from adhesion and transcription to RNA regulation. Anim. Cells Syst. 17, 299-305.
DOI
|
3 |
Hutter, C., and Zenklusen, J.C. (2018). The Cancer Genome Atlas: Creating Lasting Value beyond Its Data. Cell 173, 283-285.
DOI
|
4 |
Hyman, D.M., Taylor, B.S., and Baselga, J. (2017). Implementing Genome-Driven Oncology. Cell 168, 584-599.
DOI
|
5 |
Kim, H., Vick, P., Hedtke, J., Ploper, D., and De Robertis, E.M. (2015). Wnt signaling translocates Lys48-linked polyubiquitinated proteins to the lysosomal pathway. Cell Rep. 11, 1151-1159.
DOI
|
6 |
Kim, I., Kwak, H., Lee, H.K., Hyun, S., and Jeong, S. (2012). -Catenin recognizes a specific RNA motif in the cyclooxygenase-2 mRNA 3'-UTR and interacts with HuR in colon cancer cells. Nucleic Acids Res. 40, 6863-6872.
DOI
|
7 |
Kim, J.S., Crooks, H., Foxworth, A., and Waldman, T. (2002). Proofof-principle: oncogenic -catenin is a valid molecular target for the development of pharmacological inhibitors. Mol. Cancer Ther. 1, 1355-1359.
|
8 |
Kim, M.Y., Hur, J., and Jeong, S. (2009). Emerging roles of RNA and RNA-binding protein network in cancer cells. BMB Rep. 42, 125-130.
DOI
|
9 |
Kim, S.E., Huang, H., Zhao, M., Zhang, X., Zhang, A., Semonov, M.V., MacDonald, B.T., Zhang, X., Garcia Abreu, J., Peng, L., et al. (2013). Wnt stabilization of -catenin reveals principles for morphogen receptor-scaffold assemblies. Science 340, 867-870.
DOI
|
10 |
Korinek, V., Barker, N., Morin, P.J., van Wichen, D., de Weger, R., Kinzler, K.W., Vogelstein, B., and Clevers, H. (1997). Constitutive transcriptional activation by a -catenin-Tcf complex in APC-/- colon carcinoma. Science 275, 1784-1787.
DOI
|
11 |
Kotler, E., Shani, O., Goldfeld, G., Lotan-Pompan, M., Tarcic, O., Gershoni, A., Hopf, T.A., Marks, D.S., Oren, M., and Segal, E. (2018). A systematic p53 mutation library links differential functional impact to cancer mutation pattern and evolutionary conservation. Mol. Cell 71, 178-190 e178.
DOI
|
12 |
Krishnamurthy, N., and Kurzrock, R. (2018). Targeting the Wnt/-catenin pathway in cancer: Update on effectors and inhibitors. Cancer Treat Rev. 62, 50-60.
DOI
|
13 |
Kumar, R., and Bashyam, M.D. (2017). Multiple oncogenic roles of nuclear -catenin. J. Biosci. 42, 695-707.
DOI
|
14 |
Kurnit, K.C., Kim, G.N., Fellman, B.M., Urbauer, D.L., Mills, G.B., Zhang, W., and Broaddus, R.R. (2017). CTNNB1 (-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence. Mod. Pathol. 30, 1032-1041.
DOI
|
15 |
Le Gallo, M., Rudd, M.L., Urick, M.E., Hansen, N.F., Zhang, S., Program, N.C.S., Lozy, F., Sgroi, D.C., Vidal Bel, A., Matias-Guiu, X., et al. (2017). Somatic mutation profiles of clear cell endometrial tumors revealed by whole exome and targeted gene sequencing. Cancer 123, 3261-3268.
DOI
|
16 |
Lee, H.K., and Jeong, S. (2006). -Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR. Nucleic acids Res. 34, 5705-5714.
DOI
|
17 |
Maher, M.T., Mo, R., Flozak, A.S., Peled, O.N., and Gottardi, C.J. (2010). -catenin phosphorylated at serine 45 is spatially uncoupled from -catenin phosphorylated in the GSK3 domain: implications for signaling. PloS one 5, e10184.
DOI
|
18 |
Li, V.S., Ng, S.S., Boersema, P.J., Low, T.Y., Karthaus, W.R., Gerlach, J.P., Mohammed, S., Heck, A.J., Maurice, M.M., Mahmoudi, T., et al. (2012). Wnt signaling through inhibition of -catenin degradation in an intact Axin1 complex. Cell 149, 1245-1256.
DOI
|
19 |
Liu, C., Li, Y., Semenov, M., Han, C., Baeg, G.-H., Tan, Y., Zhang, Z., Lin, X., and He, X. (2002). Control of -cateninphosphorylation/degradation by a dual-kinase mechanism. Cell 108, 837-847.
DOI
|
20 |
Liu, Y., Patel, L., Mills, G.B., Lu, K.H., Sood, A.K., Ding, L., Kucherlapati, R., Mardis, E.R., Levine, D.A., Shmulevich, I., et al. (2014). Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma. J. Natl. Cancer Inst. 106.
|
21 |
Megy, S., Bertho, G., Gharbi-Benarous, J., Baleux, F., Benarous, R., and Girault, J.P. (2005). Solution structure of a peptide derived from the oncogenic protein -Catenin in its phosphorylated and nonphosphorylated states. Peptides 26, 227-241.
DOI
|
22 |
Miyoshi, H., Deguchi, A., Nakau, M., Kojima, Y., Mori, A., Oshima, M., Aoki, M., and Taketo, M.M. (2009). Hepatocellular carcinoma development induced by conditional -catenin activation in Lkb1+/-mice. Cancer Sci. 100, 2046-2053.
DOI
|
23 |
Morin, P.J., Sparks, A.B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K.W. (1997). Activation of -catenin-Tcf signaling in colon cancer by mutations in -catenin or APC. Science 275, 1787-1790.
DOI
|
24 |
Nusse, R., and Clevers, H. (2017). Wnt/-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Cell 169, 985-999.
DOI
|
25 |
Naus, J.I. (1982). Approximations for distributions of scan statistics. J. Am. Stat. Assoc. 77, 177-183.
DOI
|
26 |
Nejak-Bowen, K.N., and Monga, S.P. (2011). -catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. Semin. Cancer Biol. 21, 44-58.
DOI
|
27 |
Nejak-Bowen, K.N., Thompson, M.D., Singh, S., Bowen, W.C., Dar, M.J., Khillan, J., Dai, C., and Monga, S.P.S. (2010). Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant -catenin. Hepatology 51, 1603-1613.
DOI
|
28 |
Ozawa, M., Baribault, H., and Kemler, R. (1989). The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 8, 1711-1717.
DOI
|
29 |
Pilati, C., Letouze, E., Nault, J.C., Imbeaud, S., Boulai, A., Calderaro, J., Poussin, K., Franconi, A., Couchy, G., Morcrette, G., et al. (2014). Genomic profiling of hepatocellular adenomas reveals recurrent FRKactivating mutations and the mechanisms of malignant transformation. Cancer cell 25, 428-441.
DOI
|
30 |
Polakis, P. (2007). The many ways of Wnt in cancer. Curr Opin Genet Dev 17, 45-51.
DOI
|
31 |
Polakis, P. (2012a). Drugging Wnt signalling in cancer. EMBO J. 31, 2737-2746.
DOI
|
32 |
Polakis, P. (2012b). Wnt signaling in cancer. Cold Spring Harbor perspectives in biology 4.
|
33 |
Schulze, K., Imbeaud, S., Letouze, E., Alexandrov, L.B., Calderaro, J., Rebouissou, S., Couchy, G., Meiller, C., Shinde, J., Soysouvanh, F., et al. (2015). Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat. Genet. 47, 505-511.
DOI
|
34 |
Rebouissou, S., Franconi, A., Calderaro, J., Letouze, E., Imbeaud, S., Pilati, C., Nault, J.C., Couchy, G., Laurent, A., Balabaud, C., et al. (2016). Genotype-phenotype correlation of CTNNB1 mutations reveals different ss-catenin activity associated with liver tumor progression. Hepatology 64, 2047-2061.
DOI
|
35 |
Roh, H., Green, D.W., Boswell, C.B., Pippin, J.A., and Drebin, J.A. (2001). Suppression of -catenin inhibits the neoplastic growth of APC-mutant colon cancer cells. Cancer Res. 61, 6563-6568.
|
36 |
Sampietro, J., Dahlberg, C.L., Cho, U.S., Hinds, T.R., Kimelman, D., and Xu, W. (2006). Crystal structure of a -catenin/BCL9/Tcf4 complex. Mol. Cell 24, 293-300.
DOI
|
37 |
Seshagiri, S., Stawiski, E.W., Durinck, S., Modrusan, Z., Storm, E.E., Conboy, C.B., Chaudhuri, S., Guan, Y., Janakiraman, V., Jaiswal, B.S., et al. (2012). Recurrent R-spondin fusions in colon cancer. Nature 488, 660-664.
DOI
|
38 |
Sim, N.L., Kumar, P., Hu, J., Henikoff, S., Schneider, G., and Ng, P.C. (2012). SIFT web server: predicting effects of amino acid substitutions on proteins. Nucleic Acids Res. 40, W452-457.
DOI
|
39 |
Soumerai, T.E., Donoghue, M.T.A., Bandlamudi, C., Srinivasan, P., Chang, M.T., Zamarin, D., Cadoo, K.A., Grisham, R.N., O'Cearbhaill, R.E., Tew, W.P., et al. (2018). Clinical utility of prospective molecular characterization in advanced endometrial cancer. Clin. Cancer Res. 24, 5939-5947.
DOI
|
40 |
Stamos, J.L., and Weis, W.I. (2013). The -catenin destruction complex. Cold Spring Harb. Perspect. Biol. 5, a007898.
DOI
|
41 |
Taelman, V.F., Dobrowolski, R., Plouhinec, J.L., Fuentealba, L.C., Vorwald, P.P., Gumper, I., Sabatini, D.D., and De Robertis, E.M. (2010). Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell 143, 1136-1148.
DOI
|
42 |
Tomczak, K., Czerwinska, P., and Wiznerowicz, M. (2015). The cancer genome atlas (TCGA): an immeasurable source of knowledge. Contemp Oncol (Pozn) 19, A68-77.
|
43 |
Valenta, T., Hausmann, G., and Basler, K. (2012). The many faces and functions of -catenin. EMBO J. 31, 2714-2736.
DOI
|
44 |
van der Zee, M., Jia, Y., Wang, Y., Heijmans-Antonissen, C., Ewing, P.C., Franken, P., DeMayo, F.J., Lydon, J.P., Burger, C.W., Fodde, R., et al. (2013). Alterations in Wnt--catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression. J. Pathol. 230, 48-58.
DOI
|
45 |
Wang, Z.H., Vogelstein, B., and Kinzler, K.W. (2003). Phosphorylation of -catenin at S33, S37, or T41 can occur in the absence of phosphorylation at T45 in colon cancer cells. Cancer Res. 63, 5234-5235.
|
46 |
Xing, Y., Takemaru, K., Liu, J., Berndt, J.D., Zheng, J.J., Moon, R.T., and Xu, W. (2008). Crystal structure of a full-length -catenin. Structure 16, 478-487.
DOI
|
47 |
Xu, W., and Kimelman, D. (2007). Mechanistic insights from structural studies of -catenin and its binding partners. J. Cell Sci. 120, 3337-3344.
DOI
|
48 |
Ahn, S.M., Jang, S.J., Shim, J.H., Kim, D., Hong, S.M., Sung, C.O., Baek, D., Haq, F., Ansari, A.A., Lee, S.Y., et al. (2014). Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification. Hepatology 60, 1972-1982.
DOI
|
49 |
Yaeger, R., Chatila, W.K., Lipsyc, M.D., Hechtman, J.F., Cercek, A., Sanchez-Vega, F., Jayakumaran, G., Middha, S., Zehir, A., Donoghue, M.T.A., et al. (2018). Clinical sequencing defines the genomic landscape of metastatic colorectal cancer. Cancer cell 33, 125-136e123.
DOI
|
50 |
Zehir, A., Benayed, R., Shah, R.H., Syed, A., Middha, S., Kim, H.R., Srinivasan, P., Gao, J., Chakravarty, D., Devlin, S.M., et al. (2017). Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat. Med. 23, 703-713.
DOI
|
51 |
Blum, A., Wang, P., and Zenklusen, J.C. (2018). SnapShot: TCGAanalyzed tumors. Cell 173, 530.
DOI
|
52 |
Cancer Genome Atlas Research, N., Kandoth, C., Schultz, N., Cherniack, A.D., Akbani, R., Liu, Y., Shen, H., Robertson, A.G., Pashtan, I., Shen, R., et al. (2013a). Integrated genomic characterization of endometrial carcinoma. Nature 497, 67-73.
DOI
|
53 |
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., and Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394-424.
DOI
|
54 |
Bykov, V.J.N., Eriksson, S.E., Bianchi, J., and Wiman, K.G. (2018). Targeting mutant p53 for efficient cancer therapy. Nat. Rev. Cancer 18, 89-102.
DOI
|
55 |
Cancer Genome Atlas, N. (2012). Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337.
DOI
|
56 |
Cancer Genome Atlas Research, N., Weinstein, J.N., Collisson, E.A., Mills, G.B., Shaw, K.R., Ozenberger, B.A., Ellrott, K., Shmulevich, I., Sander, C., and Stuart, J.M. (2013b). The cancer genome atlas pancancer analysis project. Nat. Genet. 45, 1113-1120.
DOI
|
57 |
Cerami, E., Gao, J., Dogrusoz, U., Gross, B.E., Sumer, S.O., Aksoy, B.A., Jacobsen, A., Byrne, C.J., Heuer, M.L., Larsson, E., et al. (2012). The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2, 401-404.
DOI
|
58 |
Colombo, C., Belfiore, A., Paielli, N., De Cecco, L., Canevari, S., Laurini, E., Fermeglia, M., Pricl, S., Verderio, P., Bottelli, S., et al. (2017). -catenin in desmoid-type fibromatosis: deep insights into the role of T41A and S45F mutations on protein structure and gene expression. Mol. Oncol. 11, 1495-1507.
DOI
|
59 |
Cui, C., Zhou, X., Zhang, W., Qu, Y., and Ke, X. (2018). Is -catenin a druggable target for cancer therapy? Trends Biochem. Sci. 43, 623-634.
DOI
|
60 |
Aberle, H., Bauer, A., Stappert, J., Kispert, A., and Kemler, R. (1997). -catenin is a target for the ubiquitin-proteosome pathway. EMBO J. 16, 3797-3804.
DOI
|
61 |
Adzhubei, I.A., Schmidt, S., Peshkin, L., Ramensky, V.E., Gerasimova, A., Bork, P., Kondrashov, A.S., and Sunyaev, S.R. (2010). A method and server for predicting damaging missense mutations. Nat. Methods. 7, 248-249.
DOI
|
62 |
Dar, M.S., Singh, P., Mir, R.A., and Dar, M.J. (2017). -catenin Nterminal domain: An enigmatic region prone to cancer causing mutations. Mutat. Res. 773, 122-133.
DOI
|
63 |
Dar, M.S., Singh, P., Singh, G., Jamwal, G., Hussain, S.S., Rana, A., Akhter, Y., Monga, S.P., and Dar, M.J. (2016). Terminal regions of -catenin are critical for regulating its adhesion and transcription functions. Biochim. Biophys. Acta 1863, 2345-2357.
DOI
|
64 |
Fujimoto, A., Totoki, Y., Abe, T., Boroevich, K.A., Hosoda, F., Nguyen, H.H., Aoki, M., Hosono, N., Kubo, M., Miya, F., et al. (2012). Wholegenome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat. Genet. 44, 760-764.
DOI
|
65 |
Gao, J., Aksoy, B.A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S.O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013). Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci. Signal. 6, pl1.
|
66 |
Giannakis, M., Mu, X.J., Shukla, S.A., Qian, Z.R., Cohen, O., Nishihara, R., Bahl, S., Cao, Y., Amin-Mansour, A., Yamauchi, M., et al. (2016). Genomic correlates of immune-cell infiltrates in colorectal carcinoma. Cell Rep. 15, 857-865.
DOI
|
67 |
Gottardi, C.J., and Peifer, M. (2008). Terminal regions of -catenin come into view. Structure 16, 336-338.
DOI
|
68 |
Guichard, C., Amaddeo, G., Imbeaud, S., Ladeiro, Y., Pelletier, L., Maad, I.B., Calderaro, J., Bioulac-Sage, P., Letexier, M., Degos, F., et al. (2012). Integrated analysis of somatic mutations and focal copynumber changes identifies key genes and pathways in hepatocellular carcinoma. Nat. Genet. 44, 694-698.
DOI
|
69 |
Graham, T.A., Ferkey, D.M., Mao, F., Kimelman, D., and Xu, W. (2001). Tcf4 can specifically recognize -catenin using alternative conformations. Nat. Struct. Biol. 8, 1048-1052.
DOI
|
70 |
Green, D.W., Roh, H., Pippin, J.A., and Drebin, J.A. (2001). -catenin antisense treatment decreases -catenin expression and tumor growth rate in colon carcinoma xenografts. J. Surg. Res. 101, 16-20.
DOI
|
71 |
Hamada, S., Futamura, N., Ikuta, K., Urakawa, H., Kozawa, E., Ishiguro, N., and Nishida, Y. (2014). CTNNB1 S45F mutation predicts poor efficacy of meloxicam treatment for desmoid tumors: a pilot study. PloS one 9, e96391.
DOI
|
72 |
Harada, N., Miyoshi, H., Murai, N., Oshima, H., Tamai, Y., Oshima, M., and Taketo, M.M. (2002). Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of -catenin. Cancer Res. 62, 1971-1977.
|
73 |
Harada, N., Oshima, H., Katoh, M., Tamai, Y., Oshima, M., and Taketo, M.M. (2004). Hepatocarcinogenesis in mice with -catenin and Ha-ras gene mutations. Cancer Res. 64, 48-54.
DOI
|
74 |
Hart, M., Concordet, J.-P., Lassot, I., A;bert, O., Santos, E., Durand, H., Perret, C., Rubinfeld, B., Margottin, F., Benarous, R., et al. (1998). The F-box protein -TrCP associates with phosphorylated -catenin and regulates its activity in the cell. Curr. Biol. 9, 207-210.
DOI
|