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http://dx.doi.org/10.14348/molcells.2018.0202

Structural Basis for LAR-RPTP-Mediated Synaptogenesis  

Won, Seoung Youn (Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST))
Kim, Ho Min (Graduate School of Medical Science & Engineering, Korea Advanced Institute of Science and Technology (KAIST))
Publication Information
Molecules and Cells / v.41, no.7, 2018 , pp. 622-630 More about this Journal
Abstract
Leukocyte common antigen-related protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that regulate neurite outgrowth and neuronal regeneration. LAR-RPTPs have also received particular attention as the major presynaptic hubs for synapse organization through selective binding to numerous postsynaptic adhesion partners. Recent structural studies on LAR-RPTP-mediated trans-synaptic adhesion complexes have provided significant insight into the molecular basis of their specific interactions, the key codes for their selective binding, as well as the higher-order clustering of LAR-RPTPs necessary for synaptogenic activity. In this review, we summarize the structures of LAR-RPTPs in complex with various postsynaptic adhesion partners and discuss the molecular mechanisms underlying LAR-RPTP-mediated synaptogenesis.
Keywords
heparan sulfate; higher-order clustering; LAR-RPTPs; LAR-RPTP-mediated trans-synaptic adhesion complex; synaptic adhesion molecules;
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