Generation of Isthmic Organizer-Like Cells from Human Embryonic Stem Cells |
Lee, Junwon
(Department of Physiology, Yonsei University College of Medicine)
Choi, Sang-Hwi (Department of Physiology, Yonsei University College of Medicine) Lee, Dongjin R (Department of Physiology, Yonsei University College of Medicine) Kim, Dae-Sung (Department of Biotechnology, Brain Korea 21 PLUS Project for Biotechnology, College of Life Sciences and Biotechnology, Korea University) Kim, Dong-Wook (Department of Physiology, Yonsei University College of Medicine) |
1 | Martinez, S., Crossley, P.H., Cobos, I., Rubenstein, J.L., and Martin, G.R. (1999). FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. Development 126, 1189-1200. |
2 | Irving, C., and Mason, I. (2000). Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression. Development 127, 177-186. |
3 | Kiecker, C., and Lumsden, A. (2005). Compartments and their boundaries in vertebrate brain development. Nat. Rev. Neurosci. 6, 553-564. DOI |
4 | Kiecker, C., and Lumsden, A. (2012). The role of organizers in patterning the nervous system. Annu. Rev. Neurosci. 35, 347-367. DOI |
5 | Kim, D.S., Lee, J.S., Leem, J.W., Huh, Y.J., Kim, J.Y., Kim, H.S., Park, I.H., Daley, G.Q., Hwang, D.Y., and Kim, D.W. (2010). Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity. Stem Cell Rev. 6, 270-281. DOI |
6 | Kirkeby, A., Grealish, S., Wolf, D.A., Nelander, J., Wood, J., Lundblad, M., Lindvall, O., and Parmar, M. (2012). Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. Cell Rep. 1, 703-714. DOI |
7 | Kiyasova, V., and Gaspar, P. (2011). Development of raphe serotonin neurons from specification to guidance. Eur. J. Neurosci. 34, 1553-1562. DOI |
8 | Lancaster, M.A., Renner, M., Martin, C.A., Wenzel, D., Bicknell, L.S., Hurles, M.E., Homfray, T., Penninger, J.M., Jackson, A.P., and Knoblich, J.A. (2013). Cerebral organoids model human brain development and microcephaly. Nature 501, 373-379. DOI |
9 | Barkovich, A.J., Millen, K.J., and Dobyns, W.B. (2009). A developmental and genetic classification for midbrain-hindbrain malformations. Brain 132, 3199-3230. DOI |
10 | Basson, M.A., and Wingate, R.J. (2013). Congenital hypoplasia of the cerebellum: developmental causes and behavioral consequences. Front. Neuroanat. 7, 29. |
11 | Canning, C.A., Lee, L., Irving, C., Mason, I., and Jones, C.M. (2007). Sustained interactive Wnt and FGF signaling is required to maintain isthmic identity. Dev. Biol. 305, 276-286. DOI |
12 | Benjamini, Y., and Yekutieli, D. (2001). The control of the false discovery rate in multiple testing under dependency. Ann. Stat. 29, 1165-1188. DOI |
13 | Blaess, S., and Ang, S. (2015). Genetic control of midbrain dopaminergic neuron development. Wiley Interdisciplinary Reviews -Developmental Biology 4, 113-134. DOI |
14 | Broccoli, V., Boncinelli, E., and Wurst, W. (1999). The caudal limit of Otx2 expression positions the isthmic organizer. Nature 401, 164-168. DOI |
15 | Nordstrom, U., Jessell, T.M., and Edlund, T. (2002). Progressive induction of caudal neural character by graded Wnt signaling. Nat. Neurosci. 5, 525-532. DOI |
16 | McMahon, A.P., Joyner, A.L., Bradley, A., and McMahon, J.A. (1992). The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell 69, 581-595. DOI |
17 | Millet, S., Campbell, K., Epstein, D.J., Losos, K., Harris, E., and Joyner, A.L. (1999). A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer. Nature 401, 161-164. DOI |
18 | Naujok, O., Lentes, J., Diekmann, U., Davenport, C., and Lenzen, S. (2014). Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors. BMC Res. Notes 7, 273. DOI |
19 | Olander, S., Nordstrom, U., Patthey, C., and Edlund, T. (2006). Convergent Wnt and FGF signaling at the gastrula stage induce the formation of the isthmic organizer. Mech. Dev. 123, 166-176. DOI |
20 | Partanen, J. (2007). FGF signalling pathways in development of the midbrain and anterior hindbrain. J. Neurochem. 101, 1185-1193. DOI |
21 | Pfaffl, M.W. (2001). A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45. DOI |
22 | Wurst, W., and Bally-Cuif, L. (2001). Neural plate patterning: upstream and downstream of the isthmic organizer. Nat. Rev. Neurosci. 2, 99-108. DOI |
23 | Ciani, L., and Salinas, P.C. (2005). WNTs in the vertebrate nervous system: from patterning to neuronal connectivity. Nat. Rev. Neurosci. 6, 351-362. |
24 | Rhinn, M., and Brand, M. (2001). The midbrain--hindbrain boundary organizer. Curr. Opin. Neurobiol. 11, 34-42. DOI |
25 | Crossley, P.H., Martinez, S., and Martin, G.R. (1996). Midbrain development induced by FGF8 in the chick embryo. Nature 380, 66-68. DOI |
26 | de Lau, W., Peng, W.C., Gros, P., and Clevers, H. (2014). The Rspondin/ Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes Dev. 28, 305-316. DOI |
27 | Shimamura, K., and Rubenstein, J.L. (1997). Inductive interactions direct early regionalization of the mouse forebrain. Development 124, 2709-2718. |
28 | Simeone, A. (2000). Positioning the isthmic organizer where Otx2 and Gbx2meet. Trends Genet. 16, 237-240. DOI |
29 | Stern, C.D. (2001). Initial patterning of the central nervous system: how many organizers? Nat. Rev. Neurosci. 2, 92-98. DOI |
30 | Lupo, G., Bertacchi, M., Carucci, N., Augusti-Tocco, G., Biagioni, S., and Cremisi, F. (2014). From pluripotency to forebrain patterning: an in vitro journey astride embryonic stem cells. Cell. Mol. Life Sci. 71, 2917-2930. DOI |
![]() |