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http://dx.doi.org/10.14348/molcells.2018.2245

Pexophagy: Molecular Mechanisms and Implications for Health and Diseases  

Cho, Dong-Hyung (Graduate School of East-West Medical Science, Kyung Hee University)
Kim, Yi Sak (Department of Microbiology, Chungnam National University School of Medicine)
Jo, Doo Sin (Graduate School of East-West Medical Science, Kyung Hee University)
Choe, Seong-Kyu (Department of Microbiology and Center for Metabolic Function Regulation, Wonkwang University School of Medicine)
Jo, Eun-Kyeong (Department of Microbiology, Chungnam National University School of Medicine)
Publication Information
Molecules and Cells / v.41, no.1, 2018 , pp. 55-64 More about this Journal
Abstract
Autophagy is an intracellular degradation pathway for large protein aggregates and damaged organelles. Recent studies have indicated that autophagy targets cargoes through a selective degradation pathway called selective autophagy. Peroxisomes are dynamic organelles that are crucial for health and development. Pexophagy is selective autophagy that targets peroxisomes and is essential for the maintenance of homeostasis of peroxisomes, which is necessary in the prevention of various peroxisome-related disorders. However, the mechanisms by which pexophagy is regulated and the key players that induce and modulate pexophagy are largely unknown. In this review, we focus on our current understanding of how pexophagy is induced and regulated, and the selective adaptors involved in mediating pexophagy. Furthermore, we discuss current findings on the roles of pexophagy in physiological and pathological responses, which provide insight into the clinical relevance of pexophagy regulation. Understanding how pexophagy interacts with various biological functions will provide fundamental insights into the function of pexophagy and facilitate the development of novel therapeutics against peroxisomal dysfunction-related diseases.
Keywords
pexophagy; peroxisomal disorder; peroxisomal protein; peroxisome; selective autophagy receptor;
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