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http://dx.doi.org/10.14348/molcells.2018.2215

Biological Roles of Alternative Autophagy  

Shimizu, Shigeomi (Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University)
Publication Information
Molecules and Cells / v.41, no.1, 2018 , pp. 50-54 More about this Journal
Abstract
Atg5 and Atg7 have long been considered as essential molecules for autophagy. However, we found that cells lacking these molecules still form autophagic vacuoles and perform autophagic protein degradation when subjected to certain stressors. During this unconventional autophagy pathway, autophagosomes appeared to be generated in a Rab9-dependent manner by the fusion of vesicles derived from the trans-Golgi and late endosomes. Therefore, mammalian autophagy can occur via at least two different pathways; the Atg5/Atg7-dependent conventional pathway and an Atg5/Atg7-independent alternative pathway.
Keywords
alternative autophagy; Atg5; erythrocyte maturation; Golgi membrane; proteolysis;
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