[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.14348/molcells.2018.2277

A Molecular Approach to Mitophagy and Mitochondrial Dynamics

Yoo, Seung-Min (Global Research Laboratory, School of Biological Sciences, Seoul National University)
Jung, Yong-Keun (Global Research Laboratory, School of Biological Sciences, Seoul National University)

Abstract

Mitochondrial quality control systems are essential for the maintenance of functional mitochondria. At the organelle level, they include mitochondrial biogenesis, fusion and fission, to compensate for mitochondrial function, and mitophagy, for degrading damaged mitochondria. Specifically, in mitophagy, the target mitochondria are recognized by the autophagosomes and delivered to the lysosome for degradation. In this review, we describe the mechanisms of mitophagy and the factors that play an important role in this process. In particular, we focus on the roles of mitophagy adapters and receptors in the recognition of damaged mitochondria by autophagosomes. In addition, we also address a functional association of mitophagy with mitochondrial dynamics through the interaction of mitophagy adaptor and receptor proteins with mitochondrial fusion and fission proteins.

Keywords

autophagy; mitochondria; mitochondrial quality control; mitophagy; selective autophagy;

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Times Cited By KSCI : 1 (Citation Analysis)

Reference
Cited By KSCI

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3	(2018) Molecular medicine reports Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice / 22 (3) , 1847
4	(2020) Medicinal research reviews How autophagy can restore proteostasis defects in multiple diseases? / 40 (4) , 1385
None	(2018) Experimental neurology Mitochondrial damage & lipid signaling in traumatic brain injury / 329 (None) , 113307
None	(2020) Mechanisms of ageing and development Mitochondria (cross)talk with proteostatic mechanisms: Focusing on ageing and neurodegenerative diseases / 190 (None) , 111324
9	(2018) Life Mitonuclear Interactions in the Maintenance of Mitochondrial Integrity / 10 (9) , 173
3	(2020) Toxics Increased Mitochondrial Fragmentation Mediated by Dynamin-Related Protein 1 Contributes to Hexavalent Chromium-Induced Mitochondrial Respiratory Chain Complex I-Dependent Cytotoxicity / 8 (3) , 50
9	(2020) PLoS ONE PINK1 alleviates thermal hypersensitivity in a paclitaxel-induced <I>Drosophila</I> model of peripheral neuropathy / 15 (9) , e0239126
10	(2020) Aging cell Metabolic dysfunction in human skin: Restoration of mitochondrial integrity and metabolic output by nicotinamide (niacinamide) in primary dermal fibroblasts from older aged donors / 19 (10) , e13248
None	(2018) Seminars in cancer biology Autophagy in cancer: Recent advances and future directions / 66 (None) , 171
11	(2018) Autophagy Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy / 16 (11) , 1989
7	(2018) Current Alzheimer research Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer’s Disease Patients / 17 (7) , 616
12	(2018) Molecular cancer therapeutics Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome-Induced Cell Death in Head and Neck Squamous Cell Carcinoma / 19 (12) , 2621
None	(2018) Journal of neuroinflammation HMGB1/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia / 17 (None) , 15
24	(2018) International journal of molecular sciences Mitophagy and the Brain / 21 (24) , 9661
None	(2018) Oxidative medicine and cellular longevity The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases / 2021 (None) , 1
12	(2020) Journal of microbiology and biotechnology Mitophagy Improves Ethanol Tolerance in Yeast: Regulation by Mitochondrial Reactive Oxygen Species in Saccharomyces cerevisiae / 30 (12) , 1876
1	(2018) Biology The Impact of Mitochondrial Fission-Stimulated ROS Production on Pro-Apoptotic Chemotherapy / 10 (1) , 33
None	(2018) Oxidative medicine and cellular longevity Reactive Oxygen Species as a Link between Antioxidant Pathways and Autophagy / 2021 (None) , 1
None	(2018) Oxidative medicine and cellular longevity Qiangji Jianli Decoction Alleviates Hydrogen Peroxide-Induced Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics and Biogenesis in L6 Myoblasts / 2021 (None) , 1
None	(2018) Oxidative medicine and cellular longevity Involvement of Mitochondrial Dynamics and Mitophagy in Sevoflurane-Induced Cell Toxicity / 2021 (None) , 1
None	(2021) Evidence-based Complementary and Alternative Medicine : eCAM RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats / 2021 (None) , 1
None	(2021) Frontiers in neuroscience Defective Autophagy and Mitophagy in Aging and Alzheimer’s Disease / 14 (None) , 612757
None	(2018) Frontiers in pharmacology Neuroprotective Role of GLP-1 Analog for Retinal Ganglion Cells via PINK1/Parkin-Mediated Mitophagy in Diabetic Retinopathy / 11 (None) , 589114
None	(2021) Frontiers in physiology Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System / 12 (None) , 629914
None	(2018) Frontiers in cell and developmental biology The Mitochondrial Response to DNA Damage / 9 (None) , 669379
None	(2018) Frontiers in cell and developmental biology Mitophagy in Diabetic Kidney Disease / 9 (None) , 778011
None	(2018) Frontiers in cell and developmental biology FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases / 9 (None) , 788634
3	(2018) Journal of the science of food and agriculture Baicalin attenuated <I>Mycoplasma gallisepticum</I>‐induced immune impairment in chicken bursa of fabricius through modulation of autophagy and inhibited inflammation and apoptosis / 101 (3) , 880
6	(2018) Future oncology To betray or to fight? The dual identity of the mitochondria in cancer / 17 (6) , 723
None	(2018) Brain research bulletin Critical role of dysfunctional mitochondria and defective mitophagy in autism spectrum disorders / 168 (None) , 138
5	(2018) International journal of molecular sciences A Commonly Used Biocide 2-N-octyl-4-isothiazolin-3-oneInduces Blood-Brain Barrier Dysfunction via Cellular Thiol Modification and Mitochondrial Damage / 22 (5) , 2563
3	(2018) Biomedicines From Mitochondria to Atherosclerosis: The Inflammation Path / 9 (3) , 258
3	(2018) Life Role of Mitochondria in Viral Infections / 11 (3) , 232
2	(2018) Neurotoxicity research Involvement of Mitophagy in Aluminum Oxide Nanoparticle-Induced Impairment of Learning and Memory in Mice / 39 (2) , 378
None	(2018) Pharmacological research : the official journal of the Italian Pharmacological Society Mechanistic insights into AMPK-SIRT3 positive feedback loop-mediated chondrocyte mitochondrial quality control in osteoarthritis pathogenesis / 166 (None) , 105497
None	(2021) Environmental pollution Mitochondrial dynamics and mitophagy involved in MPA-capped CdTe quantum dots-induced toxicity in the human liver carcinoma (HepG2) cell line / 274 (None) , 115681
3	(2018) Pharmacology research & perspectives Drp1‐dependent peptide reverse mitochondrial fragmentation, a homeostatic response in Friedreich ataxia / 9 (3) , None
10	(2018) Cancers The Role of Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy / 13 (10) , 2475
10	(2018) International journal of molecular sciences Rapamycin Ameliorates Defects in Mitochondrial Fission and Mitophagy in Glioblastoma Cells / 22 (10) , 5379
5	(2018) Antioxidants Mitophagy and Oxidative Stress: The Role of Aging / 10 (5) , 794
12	(2018) International journal of molecular sciences Mitochondrial Caseinolytic Protease P: A Possible Novel Prognostic Marker and Therapeutic Target in Cancer / 22 (12) , 6228
12	(2018) Food & function <I>trans</I>,<I>trans</I>-2,4-Decadienal induces endothelial cell injury by impairing mitochondrial function and autophagic flux / 12 (12) , 5488
30	(2018) Journal of materials chemistry. B, Materials for biology and medicine Two birds with one stone: a NIR fluorescent probe for mitochondrial protein imaging and its application in photodynamic therapy / 9 (30) , 6068
8	(2018) The FASEB journal : official publication of the Federation of American Societies for Experimental Biology Polycystin‐1 regulates cardiomyocyte mitophagy / 35 (8) , None
15	(2018) International journal of molecular sciences Effects of Urolithin A on Mitochondrial Parameters in a Cellular Model of Early Alzheimer Disease / 22 (15) , 8333
15	(2021) The Journal of clinical investigation Dysregulation of mannose-6-phosphate-dependent cholesterol homeostasis in acinar cells mediates pancreatitis / 131 (15) , e146870
9	(2018) Cells HIV Increases the Inhibitory Impact of Morphine and Antiretrovirals on Autophagy in Primary Human Macrophages: Contributions to Neuropathogenesis / 10 (9) , 2183
6	(2018) Experimental and therapeutic medicine Dynamic observation of 5‑fluorouracil‑induced myocardial injury and mitochondrial autophagy in aging rats / 22 (6) , 1451
20	(2018) International journal of molecular sciences Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts / 22 (20) , 11047
21	(2018) Cancers IL-17B/RB Activation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Metabolism and Growth / 13 (21) , 5338
21	(2018) Cancers Autophagy in Cancer Therapy-Molecular Mechanisms and Current Clinical Advances / 13 (21) , 5575
11	(2021) Autophagy FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation / 17 (11) , 3389
11	(2018) ACS applied nano materials Flower-Like Molybdenum Disulfide Nanostructures for Promoting Mitochondrial Homeostasis and Attenuating Inflammatory Endothelial Dysfunction / 4 (11) , 11709
None	(2018) Ecotoxicology and environmental safety Molybdenum and cadmium co-induce hypothalamus toxicity in ducks via disturbing Nrf2-mediated defense response and triggering mitophagy / 228 (None) , 113022
1	(2021) Nature communications BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects / 12 (1) , 487
12	(2018) Journal of dairy science Nuclear factor erythroid 2-related factor 2 protects bovine mammary epithelial cells against free fatty acid-induced mitochondrial dysfunction in vitro / 104 (12) , 12830
12	(2018) Pharmaceuticals Contribution of Mitochondrial Dysfunction Combined with NLRP3 Inflammasome Activation in Selected Neurodegenerative Diseases / 14 (12) , 1221
4	(2018) Journal of Alzheimer's disease Synaptic Mitochondria: An Early Target of Amyloid-β and Tau in Alzheimer’s Disease / 84 (4) , 1391
1	(2022) Acta histochemica Drp1 knockdown represses apoptosis of rat retinal endothelial cells by inhibiting mitophagy / 124 (1) , 151837
1	(2018) Cell death & disease BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease / 13 (1) , 14
1	(2018) The FASEB journal : official publication of the Federation of American Societies for Experimental Biology IGFBP‐3 functions as a molecular switch that mediates mitochondrial and metabolic homeostasis / 36 (1) , None
1	(2018) Cells Molecular Mechanisms and Regulation of Mammalian Mitophagy / 11 (1) , 38