Inhibition of the DevSR Two-Component System by Overexpression of Mycobacterium tuberculosis PknB in Mycobacterium smegmatis |
Bae, Hyun-Jung
(Department of Microbiology, Pusan National University)
Lee, Ha-Na (Department of Microbiology, Pusan National University) Baek, Mi-Na (Department of Microbiology, Pusan National University) Park, Eun-Jin (Department of Microbiology, Pusan National University) Eom, Chi-Yong (Korea Basic Science Institute) Ko, In-Jeong (Korea Science Academy of KAIST) Kang, Ho-Young (Department of Microbiology, Pusan National University) Oh, Jeong-Il (Department of Microbiology, Pusan National University) |
1 | Baer, C.E., Iavarone, A.T., Alber, T., and Sassetti, C.M. (2014). Biochemical and spatial coincidence in the provisional Ser/Thr protein kinase interaction network of Mycobacterium tuberculosis. J. Biol. Chem. 289, 20422-20433. DOI |
2 | Pereira, S.F., Goss, L., and Dworkin, J. (2011). Eukaryote-like serine/threonine kinases and phosphatases in bacteria. Microbiol. Mol. Biol. Rev. 75, 192-212. DOI |
3 | Plocinska, R., Purushotham, G., Sarva, K., Vadrevu, I.S., Pandeeti, E.V., Arora, N., Plocinski, P., Madiraju, M.V., and Rajagopalan, M. (2012). Septal localization of the Mycobacterium tuberculosis MtrB sensor kinase promotes MtrA regulon expression. J. Biol. Chem. 287, 23887-23899. DOI |
4 |
Podust, L.M., Ioanoviciu, A., and Ortiz de Montellano, P.R. (2008). 2.3 |
5 | Prisic, S., Dankwa, S., Schwartz, D., Chou, M.F., Locasale, J.W., Kang, C.M., Bemis, G., Church, G.M., Steen, H., and Husson, R.N. (2010). Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases. Proc. Natl. Acad. Sci. USA 107, 7521-7526. DOI |
6 | Roberts, D.M., Liao, R.P., Wisedchaisri, G., Hol, W.G., and Sherman, D.R. (2004). Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis. J. Biol. Chem. 279, 23082-23087. DOI |
7 | Russell, D.G. (2007). Who puts the tubercle in tuberculosis? Nat. Rev. Microbiol. 5, 39-47. DOI |
8 | Rustad, T.R., Sherrid, A.M., Minch, K.J. and Sherman, D.R. (2009). Hypoxia: a window into Mycobacterium tuberculosis latency. Cell Microbiol. 11, 1151-1159. DOI |
9 | Saini, D.K., Malhotra, V., and Tyagi, J.S. (2004). Cross talk between DevS sensor kinase homologue, Rv2027c, and DevR response regulator of Mycobacterium tuberculosis. FEBS Lett. 565, 75-80. DOI |
10 | Sambrook J, G.M. (2012). Molecular cloning: a laboratory manual, 4th ed. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY). |
11 | Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S.V., Eiglmeier, K., Gas, S., Barry, C.E., 3rd, et al. (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537-544. DOI |
12 | Chao, J.D., Papavinasasundaram, K.G., Zheng, X., Chavez-Steenbock, A., Wang, X., Lee, G.Q., and Av-Gay, Y. (2010). Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis. J. Biol. Chem. 285, 29239-29246. DOI |
13 | Chawla, Y., Upadhyay, S., Khan, S., Nagarajan, S.N., Forti, F., and Nandicoori, V.K. (2014). Protein kinase B (PknB) of Mycobacterium tuberculosis is essential for growth of the pathogen in vitro as well as for survival within the host. J. Biol. Chem. 289, 13858-13875. DOI |
14 | Cho, H.Y., Cho, H.J., Kim, Y.M., Oh, J.I., and Kang, B.S. (2009). Structural insight into the heme-based redox sensing by DosS from Mycobacterium tuberculosis. J. Biol. Chem. 284, 13057-13067. DOI |
15 | Fernandez, P., Saint-Joanis, B., Barilone, N., Jackson, M., Gicquel, B., Cole, S.T., and Alzari, P.M. (2006). The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth. J. Bacteriol. 188, 7778-7784. DOI |
16 | Fol, M., Chauhan, A., Nair, N.K., Maloney, E., Moomey, M., Jagannath, C., Madiraju, M.V., and Rajagopalan, M. (2006). Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator. Mol. Microbiol. 60, 643-657. DOI |
17 | Fontan, P., Walters, S., and Smith, I. (2004). Cellular signaling pathways and transcriptional regulation in Mycobacterium tuberculosis: stress control and virulence. Curr. Sci. 86, 122-134. |
18 |
Sherman, D.R., Voskuil, M., Schnappinger, D., Liao, R., Harrell, M.I., and Schoolnik, G.K. (2001). Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding |
19 | Schnappinger, D., Ehrt, S., Voskuil, M.I., Liu, Y., Mangan, J.A., Monahan, I.M., Dolganov, G., Efron, B., Butcher, P.D., Nathan, C., et al. (2003). Transcriptional adaptation of Mycobacterium tuberculosis within Mmrophages: insights into the phagosomal environment. J. Exp. Med. 198, 693-704. DOI |
20 | Shah, I.M., Laaberki, M.H., Popham, D.L., and Dworkin, J. (2008). A eukaryotic-like Ser/Thr kinase signals bacteria to exit dormancy in response to peptidoglycan fragments. Cell 135, 486-496. DOI |
21 | Shi, L., Potts, M., and Kennelly, P.J. (1998). The serine, threonine, and/or tyrosine-specific protein kinases and protein phosphatases of prokaryotic organisms: a family portrait. FEMS Microbiol. Rev. 22, 229-253. DOI |
22 | Snapper, S.B., Melton, R.E., Mustafa, S., Kieser, T., and Jacobs, W.R., Jr. (1990). Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis. Mol. Microbiol. 4, 1911-1919. DOI |
23 | Sousa, E.H., Tuckerman, J.R., Gonzalez, G., and Gilles-Gonzalez, M.A. (2007). DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis. Protein Sci. 16, 1708-1719. DOI |
24 | Wisedchaisri, G., Wu, M., Sherman, D.R., and Hol, W.G. (2008). Crystal structures of the response regulator DosR from Mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activation. J. Mol. Biol. 378, 227-242. DOI |
25 | Stock, A.M., Robinson, V.L., and Goudreau, P.N. (2000). Twocomponent signal transduction. Annu. Rev. Biochem. 69, 183-215. DOI |
26 | Voskuil, M.I., Schnappinger, D., Visconti, K.C., Harrell, M.I., Dolganov, G.M., Sherman, D.R., and Schoolnik, G.K. (2003). Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. J. Exp. Med. 198, 705-713. DOI |
27 | Wayne, L.G. and Sohaskey, C.D. (2001). Nonreplicating persistence of Mycobacterium tuberculosis. Annu. Rev. Microbiol. 55, 139-163. DOI |
28 | Wehenkel, A., Bellinzoni, M., Grana, M., Duran, R., Villarino, A., Fernandez, P., Andre-Leroux, G., England, P., Takiff, H., Cervenansky, C., et al. (2008). Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential. Biochim. Biophys. Acta. 1784, 193-202. DOI |
29 | West, A.H. and Stock, A.M. (2001). Histidine kinases and response regulator proteins in two-component signaling systems. Trends Biochem. Sci. 26, 369-376. DOI |
30 |
Yeats, C., Finn, R.D., and Bateman, A. (2002). The PASTA domain: |
31 | Young, T.A., Delagoutte, B., Endrizzi, J.A., Falick, A.M., and Alber, T. (2003). Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases. Nat. Struct. Biol. 10, 168-174. DOI |
32 | James, J.N., Hasan, Z.U., Ioerger, T.R., Brown, A.C., Personne, Y., Carroll, P., Ikeh, M., Tilston-Lunel, N.L., Palavecino, C., Sacchettini, J.C., et al. (2012). Deletion of SenX3-RegX3, a key two-component regulatory system of Mycobacterium smegmatis, results in growth defects under phosphate-limiting conditions. Microbiology 158, 2724-2731. DOI |
33 | Fridman, M., Williams, G.D., Muzamal, U., Hunter, H., Siu, K.W., and Golemi-Kotra, D. (2013). Two unique phosphorylation-driven signaling pathways crosstalk in Staphylococcus aureus to modulate the cellwall charge: Stk1/Stp1 meets GraSR. Biochemistry 52, 7975-7986. DOI |
34 | Glover, R.T., Kriakov, J., Garforth, S.J., Baughn, A.D., and Jacobs, W.R., Jr. (2007). The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis. J. Bacteriol. 189, 5495-5503. DOI |
35 | Horstmann, N., Saldana, M., Sahasrabhojane, P., Yao, H., Su, X., Thompson, E., Koller, A., and Shelburne, S.A., 3rd (2014). Dual-site phosphorylation of the control of virulence regulator impacts group a streptococcal global gene expression and pathogenesis. PLoS Pathog. 10, e1004088. DOI |
36 | Jeong, J.A., Baek, E.Y., Kim, S.W., Choi, J.S., and Oh, J.I. (2013). Regulation of the ald gene encoding alanine dehydrogenase by AldR in Mycobacterium smegmatis. J. Bacteriol. 195, 3610-3620. DOI |
37 | Kang, C.M., Abbott, D.W., Park, S.T., Dascher, C.C., Cantley, L.C., and Husson, R.N. (2005). The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 19, 1692-1704. DOI |
38 | Kim, M.J., Park, K.J., Ko, I.J., Kim, Y.M., and Oh, J.I. (2010). Different roles of DosS and DosT in the hypoxic adaptation of Mycobacteria. J. Bacteriol. 192, 4868-4875. DOI |
39 | Zahrt, T.C. and Deretic, V. (2000). An essential two-component signal transduction system in Mycobacterium tuberculosis. J. Bacteriol. 182, 3832-3838. DOI |
40 | Kendall, S.L., Movahedzadeh, F., Rison, S.C., Wernisch, L., Parish, T., Duncan, K., Betts, J.C., and Stoker, N.G. (2004). The Mycobacterium tuberculosis dosRS two-component system is induced by multiple stresses. Tuberculosis (Edinb) 84, 247-255. DOI |
41 | Kumar, A., Toledo, J.C., Patel, R.P., Lancaster, J.R., Jr., and Steyn, A.J. (2007). Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor. Proc. Natl. Acad. Sci. U S A 104, 11568-11573. DOI |
42 | Laub, M.T., and Goulian, M. (2007). Specificity in two-component signal transduction pathways. Annu. Rev. Genet. 41, 121-145. DOI |
43 |
Lee, J.M., Cho, H.Y., Cho, H.J., Ko, I.J., Park, S.W., Baik, H.S., Oh, J.H., Eom, C.Y., Kim, Y.M., Kang, B.S., et al. (2008). |
44 | Lee, H.N., Jung, K.E., Ko, I.J., Baik, H.S., and Oh, J.I. (2012). Proteinprotein interactions between histidine kinases and response regulators of Mycobacterium tuberculosis H37Rv. J. Microbiol. 50, 270-277. DOI |
45 | Lee, H.N., Lee, N.O., Han, S.J., Ko, I.J., and Oh, J.I. (2014). Regulation of the ahpC gene encoding alkyl hydroperoxide reductase in Mycobacterium smegmatis. PLoS One 9, e111680. DOI |
46 | Leonard, C.J., Aravind, L., and Koonin, E.V. (1998). Novel families of putative protein kinases in bacteria and archaea: evolution of the "eukaryotic" protein kinase superfamily. Genome Res. 8, 1038-1047. DOI |
47 | Menon, S. and Wang, S. (2011). Structure of the response regulator PhoP from Mycobacterium tuberculosis reveals a dimer through the receiver domain. Biochemistry 50, 5948-5957. DOI |
48 | Lin, W.J., Walthers, D., Connelly, J.E., Burnside, K., Jewell, K.A., Kenney, L.J., and Rajagopal, L. (2009). Threonine phosphorylation prevents promoter DNA binding of the Group B Streptococcus response regulator CovR. Mol. Microbiol. 71, 1477-1495. DOI |
49 | Malhotra, V., Okon, B.P., and Clark-Curtiss, J.E. (2012). Mycobacterium tuberculosis protein kinase K enables growth adaptation through translation control. J. Bacteriol. 194, 4184-4196. DOI |
50 |
Mayuri, Bagchi, G., Das, T.K., and Tyagi, J.S. (2002). Molecular analysis of the dormancy response in Mycobacterium smegmatis: expression analysis of genes encoding the DevR-DevS twocomponent system, Rv3134c and chaperone |
51 | Mir, M., Asong, J., Li, X., Cardot, J., Boons, G.J., and Husson, R.N. (2011). The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization. PLoS Pathog. 7, e1002182. DOI |
52 |
Mouncey, N.J. and Kaplan, S. (1998). Redox-dependent gene regulation in Rhodobacter sphaeroides |
53 | Narayan, A., Sachdeva, P., Sharma, K., Saini, A.K., Tyagi, A.K., and Singh, Y. (2007). Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Physiol. Genomics 29, 66-75. DOI |
54 | Oh, J.I., and Kaplan, S. (1999). The cbb3 terminal oxidase of Rhodobacter sphaeroides 2.4.1: structural and functional implications for the regulation of spectral complex formation. Biochemistry 38, 2688-2696. DOI |
55 | Park, H.D., Guinn, K.M., Harrell, M.I., Liao, R., Voskuil, M.I., Tompa, M., Schoolnik, G.K., and Sherman, D.R. (2003). Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. Mol. Microbiol. 48, 833-843. DOI |
56 | Ortega, C., Liao, R., Anderson, L.N., Rustad, T., Ollodart, A.R., Wright, A.T., Sherman, D.R., and Grundner, C. (2014). Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch. PLoS Biol. 12, e1001746. DOI |
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