Down-Regulation of MicroRNA-210 Confers Sensitivity towards 1'S-1'-Acetoxychavicol Acetate (ACA) in Cervical Cancer Cells by Targeting SMAD4 |
Phuah, Neoh Hun
(Institute of Biological Sciences (Genetics and Molecular Biology), Faculty of Science, University of Malaya)
Azmi, Mohamad Nurul (Centre for Natural Product Research and Drug Discovery (CENAR), Department of Chemistry, Faculty of Science, University of Malaya) Awang, Khalijah (Centre for Natural Product Research and Drug Discovery (CENAR), Department of Chemistry, Faculty of Science, University of Malaya) Nagoor, Noor Hasima (Institute of Biological Sciences (Genetics and Molecular Biology), Faculty of Science, University of Malaya) |
1 | Qin, Q., Furong, W., and Baosheng, L. (2014). Multiple functions of hypoxia-regulated miR-210 in cancer. J. Exp. Clin. Cancer Res. 33, 50. DOI |
2 | Rao, Q., Shen, Q., Zhou, H., Peng, Y., Li, J., and Lin, Z. (2012). Aberrant microRNA expression in human cervical carcinomas. Med. Oncol. 29, 1242-1248. DOI |
3 | Tang, X., Chen, L., Yan, X., Li, Y., Xiong, Y., and Zhou, X. (2015). Overexpression of miR-210 is associated with poor prognosis of acute myeloid leukemia. Med. Sci. Monit. 21, 3427-3433. DOI |
4 | Torre, L.A., Bray, F., Siegel, R.L., Ferlay, J., Lortet-Tieulent, J., and Jemal, A. (2015). Global cancer statistics, 2012. CA Cancer J. Clin. 65, 87-108. DOI |
5 | Wu, S., Huang, S., Ding, J., Zhao, Y., Liang, L., Liu, T., Zhan, R., and He, X. (2010). Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. Oncogene 29, 2302-2308. DOI |
6 | Yang, W., Sun, T., Cao, J., Liu, F., Tian, Y., and Zhu, W. (2012). Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro. Exp. Cell Res. 318, 944-954. DOI |
7 | Yang, W., Wei, J., Sun, T., and Liu, F. (2013). Effects of knockdown of miR-210 in combination with ionizing radiation on human hepatoma xenograft in nude mice. Radiat. Oncol. 8, 102. DOI |
8 | Yu, S.L., Lee, D.C., Son, J.W., Park, C.G., Lee, H.Y., and Kang, J. (2013). Histone deacetylase 4 mediates SMAD family member 4 deacetylation and induces 5-fluorouracil resistance in breast cancer cells. Oncol. Rep. 30, 1293-1300. DOI |
9 | Zhang, B., Zhang, B., Chen, X., Bae, S., Singh, K., Washington, M.K., and Datta, P.K. (2014). Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway. Br. J. Cancer 110, 946-957. DOI |
10 | Zhang, B., Leng, C., Wu, C., Zhang, Z., Dou, L., Luo, X., Zhang, B., and Chen, X. (2016). Smad4 sensitizes colorectal cancer to 5- fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade. Oncol. Rep. 35, 1807-1815. DOI |
11 | Camps, C., Buffa, F.M., Colella, S., Moore, J., Sotiriou, C., Sheldon, H., Harris, A.L., Gleadle, J.M., and Ragoussis, J. (2008). hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer. Clin. Cancer Res. 14, 1340-1348. DOI |
12 | Awang, K., Azmi, M.N., Aun, L.I., Aziz, A.N., Ibrahim, H., and Nagoor, N.H. (2010). The apoptotic effect of 1's-1'-acetoxychavicol acetate from Alpinia conchigera on human cancer cells. Molecules 15, 8048-8059. DOI |
13 | Baez, A., Cantor, A., Fonseca, S., Marcos-Martinez, M., Mathews, L.A., Muro-Cacho, C.A., and Munoz-Antonia, T. (2005). Differences in Smad4 expression in human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck squamous cell carcinoma. Clin. Cancer Res. 11, 3191-3197. DOI |
14 | Baldus, S.E., Schwarz, E., Lohrey, C., Zapatka, M., Landsberg, S., Hahn, S.A., Schmidt, D., Dienes, H.P., Schmiegel, W.H., and Schwarte-Waldhoff, I. (2005). Smad4 deficiency in cervical carcinoma cells. Oncogene 24, 810-819. DOI |
15 | Cheng, H., Fertig, E.J., Ozawa, H., Hatakeyama, H., Howard, J.D., Perez, J., Considine, M., Thakar, M., Ranaweera, R., Krigsfeld, G., et al. (2015). Decreased SMAD4 expression is associated with induction of epithelial-to-mesenchymal transition and cetuximab resistance in head and neck squamous cell carcinoma. Cancer Biol. Ther. 16, 1252-1258. DOI |
16 | Gottesman, M.M. (2002). Mechanisms of cancer drug resistance. Annu. Rev. Med. 53, 615-627. DOI |
17 | Crafton, S.M., and Salani, R. (2016). Beyond chemotherapy: an overview and review of targeted therapy in cervical cancer. Clin. Ther. 38, 449-458. DOI |
18 | Cragg, G.M., and Newman, D.J. (2005). Plants as a source of anticancer agents. J. Ethnopharmacol. 100, 72-79. DOI |
19 | Dang, K., and Myers, K.A. (2015). The role of hypoxia-induced miR- 210 in cancer progression. Int. J. Mol. Sci. 16, 6353-6372. DOI |
20 | Greither, T., Grochola, L.F., Udelnow, A., Lautenschlager, C., Wurl, P., and Taubert, H. (2010). Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival. Int. J. Cancer 126, 73-80. DOI |
21 | Hernanda, P.Y., Chen, K., Das, A.M., Sideras, K., Wang, W., Li, J., Cao, W., Bots, S.J., Kodach, L.L., de Man, R.A., et al. (2015). SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma. Oncogene 34, 5055-5068. DOI |
22 | Ho, C.S., Yap, S.H., Phuah, N.H., In, L.L., and Hasima, N. (2014). MicroRNAs associated with tumour migration, invasion and angiogenic properties in A549 and SK-Lu1 human lung adenocarcinoma cells. Lung Cancer 83, 154-162. DOI |
23 | Jung, E.J., Santarpia, L., Kim, J., Esteva, F.J., Moretti, E., Buzdar, A.U., Di Leo, A., Le, X.F., Bast, R.C., Jr., Park, S.T., et al. (2012). Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients. Cancer 118, 2603-2614. DOI |
24 | Liang, Z., Li, S., Xu, X., Xu, X., Wang, X., Wu, J., Zhu, Y., Hu, Z., Lin, Y., Mao, Y., et al. (2015). MicroRNA-576-3p inhibits proliferation in bladder cancer cells by targeting cyclin D1. Mol. Cells 38, 130-137. DOI |
25 | Kim, Y., Kim, H., Park, D., and Jeoung, D. (2015). miR-335 targets SIAH2 and confers sensitivity to anti-cancer drugs by increasing the expression of HDAC3. Mol. Cells 38, 562-572. DOI |
26 | Klein-Scory, S., Zapatka, M., Eilert-Micus, C., Hoppe, S., Schwarz, E., Schmiegel, W., Hahn, S.A., and Schwarte-Waldhoff, I. (2007). Highlevel inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. BMC Cancer 7, 209. DOI |
27 | Kloth, J.N., Kenter, G.G., Spijker, H.S., Uljee, S., Corver, W.E., Jordanova, E.S., Fleuren, G.J., and Gorter, A. (2008). Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival. Mod. Pathol. 21, 866-875. DOI |
28 | Lagos-Quintana, M., Rauhut, R., Lendeckel, W., and Tuschl, T. (2001). Identification of novel genes coding for small expressed RNAs. Science 294, 853-858. DOI |
29 | Lee, S., Cho, Y.S., Shim, C., Kim, J., Choi, J., Oh, S., Kim, J., Zhang, W., and Lee, J. (2001). Aberrant expression of Smad4 results in resistance against the growth-inhibitory effect of transforming growth factor-beta in the SiHa human cervical carcinoma cell line. Int. J. Cancer 94, 500-507. DOI |
30 | Liu, N., Yu, C., Shi, Y., Jiang, J., and Liu, Y. (2015). SMAD4 expression in breast ductal carcinoma correlates with prognosis. Oncol. Lett. 10, 1709-1715. DOI |
31 | Livak, K.J., and Schmittgen, T.D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 25, 402-408. DOI |
32 | Lou, M., Jia, Y., Duan, Z., Wu, J., Luo, M., and Wang, Y. (2016). Correlation between human papillomavirus and microRNA-210 in hypoxia-associated human cervical cancer. Int. J. Clin. Exp. Pathol. 9, 1148-1157. |
33 | Monk, B.J., Sill, M.W., McMeekin, D.S., Cohn, D.E., Ramondetta, L.M., Boardman, C.H., Benda, J., and Cella, D. (2009). Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study. J. Clin. Oncol. 27, 4649-4655. DOI |
34 | Martinez, I., Gardiner, A.S., Board, K.F., Monzon, F.A., Edwards, R.P., and Khan, S.A. (2008). Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene 27, 2575-2582. DOI |
35 | Millimouno, F.M., Dong, J., Yang, L., Li, J., and Li, X. (2014). Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature. Cancer Prev. Res. 7, 1081-1107. DOI |
36 | Miyaki, M., Iijima, T., Konishi, M., Sakai, K., Ishii, A., Yasuno, M., Hishima, T., Koike, M., Shitara, N., Iwama, T., et al. (1999). Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene 18, 3098-3103. DOI |
37 | Phuah, N.H., In, L.L., Azmi, M.N., Ibrahim, H., Awang, K., and Nagoor, N.H. (2013). Alterations of microRNA expression patterns in human cervical carcinoma cells (Ca Ski) toward 1'S-1'- acetoxychavicol acetate and cisplatin. Reprod. Sci. 20, 567-578. DOI |
38 | Othman, N., In, L.L., Harikrishna, J.A., and Hasima, N. (2013). Bcl-xL silencing induces alterations in hsa-miR-608 expression and subsequent cell death in A549 and SK-LU1 human lung adenocarcinoma cells. PLoS One 8, e81735. DOI |
39 | Papageorgis, P., Cheng, K., Ozturk, S., Gong, Y., Lambert, A.W., Abdolmaleky, H.M., Zhou, J.R., and Thiagalingam, S. (2011). Smad4 inactivation promotes malignancy and drug resistance of colon cancer. Cancer Res. 71, 998-1008. DOI |
40 | Phuah, N.H., and Nagoor, N.H. (2014). Regulation of microRNAs by natural agents: new strategies in cancer therapies. Biomed. Res. Int. 2014, 804510. |