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http://dx.doi.org/10.14348/molcells.2017.0011

Signaling Pathways Controlling Microglia Chemotaxis  

Fan, Yang (School of Pharmaceutical Science and Technology, Tianjin University)
Xie, Lirui (School of Pharmaceutical Science and Technology, Tianjin University)
Chung, Chang Y. (School of Pharmaceutical Science and Technology, Tianjin University)
Publication Information
Molecules and Cells / v.40, no.3, 2017 , pp. 163-168 More about this Journal
Abstract
Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain's innate immune response against infection, injury, and diseases. Microglia respond to extracellular signals and engulf unwanted neuronal debris by phagocytosis, thereby maintaining normal cellular homeostasis in the CNS. Pathological stimuli such as neuronal injury induce transformation and activation of resting microglia with ramified morphology into a motile amoeboid form and activated microglia chemotax toward lesion site. This review outlines the current research on microglial activation and chemotaxis.
Keywords
activation; chemotaxis; cell migration; microglia; $P2Y_{12}$ receptor;
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