Odorant Receptors Containing Conserved Amino Acid Sequences in Transmembrane Domain 7 Display Distinct Expression Patterns in Mammalian Tissues |
Ryu, Sang Eun
(Department of Cognitive and Brain Sciences, Graduate school, Daegu Gyeongbuk Institute of Science & Technology (DGIST))
Shim, Tammy (Department of Cognitive and Brain Sciences, Graduate school, Daegu Gyeongbuk Institute of Science & Technology (DGIST)) Yi, Ju-Yeon (Department of Cognitive and Brain Sciences, Graduate school, Daegu Gyeongbuk Institute of Science & Technology (DGIST)) Kim, So Yeun (Department of Cognitive and Brain Sciences, Graduate school, Daegu Gyeongbuk Institute of Science & Technology (DGIST)) Park, Sun Hwa (Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine) Kim, Sung Won (Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine) Ronnett, Gabriele V. (Departments of Neuroscience and Neurology, The Johns Hopkins University School of Medicine) Moon, Cheil (Department of Cognitive and Brain Sciences, Graduate school, Daegu Gyeongbuk Institute of Science & Technology (DGIST)) |
1 | Asai, H., Kasai, H., Matsuda, Y., Yamazaki, N., Nagawa, F., Sakano, H., and Tsuboi, A. (1996). Genomic structure and transcription of a murine odorant receptor gene: differential initiation of transcription in the olfactory and testicular cells. Biochem. Biophys. Res. Commun. 221, 240-247. DOI |
2 | Barnea, G., O'Donnell, S., Mancia, F., Sun, X., Nemes, A., Mendelsohn, M., and Axel, R. (2004). Odorant receptors on axon termini in the brain. Science 304, 1468. DOI |
3 | Braun, T., Voland, P., Kunz, L., Prinz, C., and Gratzl, M. (2007). Enterochromaffin cells of the human gut: sensors for spices and odorants. Gastroenterology 132, 1890-1901. DOI |
4 | Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D.J. (1997). Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389-3402. DOI |
5 | de March, C.A., Kim, S.K., Antonczak, S., Goddard, W.A., 3rd, and Golebiowski, J. (2015). G protein-coupled odorant receptors: From sequence to structure. Protein Sci. 24, 1543-1548. DOI |
6 | Buck, L., and Axel, R. (1991). A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65, 175-187. DOI |
7 | Busse, D., Kudella, P., Gruning, N.M., Gisselmann, G., Stander, S., Luger, T., Jacobsen, F., Steinstrasser, L., Paus, R., Gkogkolou, P., et al. (2014). A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4. J. Invest. Dermatol. 134, 2823-2832. DOI |
8 | De la Cruz, O., Blekhman, R., Zhang, X., Nicolae, D., Firestein, S., and Gilad, Y. (2009). A signature of evolutionary constraint on a subset of ectopically expressed olfactory receptor genes. Mol. Biol. Evol. 26, 491-494. |
9 | Durzynski, L., Gaudin, J.C., Myga, M., Szydlowski, J., Gozdzicka-Jozefiak, A., and Haertle, T. (2005). Olfactory-like receptor cDNAs are present in human lingual cDNA libraries. Biochem. Biophys. Res. Commun. 333, 264-272. DOI |
10 | Feinstein, P., and Mombaerts, P. (2004). A contextual model for axonal sorting into glomeruli in the mouse olfactory system. Cell 117, 817-831. DOI |
11 | Feldmesser, E., Olender, T., Khen, M., Yanai, I., Ophir, R., and Lancet, D. (2006). Widespread ectopic expression of olfactory receptor genes. BMC Genomics 7, 121. DOI |
12 | Flegel, C., Manteniotis, S., Osthold, S., Hatt, H., and Gisselmann, G. (2013). Expression profile of ectopic olfactory receptors determined by deep sequencing. PLoS One 8, e55368. DOI |
13 | Garcia-Esparcia, P., Schluter, A., Carmona, M., Moreno, J., Ansoleaga, B., Torrejon-Escribano, B., Gustincich, S., Pujol, A., and Ferrer, I. (2013). Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain. J. Neuropathol. Exp. Neurol. 72, 524-539. DOI |
14 | Flegel, C., Vogel, F., Hofreuter, A., Schreiner, B.S., Osthold, S., Veitinger, S., Becker, C., Brockmeyer, N.H., Muschol, M., Wennemuth, G., et al. (2015). Characterization of the Olfactory Receptors Expressed in Human Spermatozoa. Front. Mol. Biosci. 2, 73. |
15 | Fukuda, N., and Touhara, K. (2006). Developmental expression patterns of testicular olfactory receptor genes during mouse spermatogenesis. Genes Cells 11, 71-81. |
16 | Gaillard, I., Rouquier, S., Chavanieu, A., Mollard, P., and Giorgi, D. (2004). Amino-acid changes acquired during evolution by olfactory receptor 912-93 modify the specificity of odorant recognition. Hum. Mol. Genet. 13, 771-780. DOI |
17 | Gaudin, J.C., Breuils, L., and Haertle, T. (2001). New GPCRs from a human lingual cDNA library. Chem. Senses 26, 1157-1166. DOI |
18 | Goto, T., Salpekar, A., and Monk, M. (2001). Expression of a testisspecific member of the olfactory receptor gene family in human primordial germ cells. Mol. Hum. Reprod. 7, 553-558. DOI |
19 | Hanchate, N.K., Kondoh, K., Lu, Z., Kuang, D., Ye, X., Qiu, X., Pachter, L., Trapnell, C., and Buck, L.B. (2015). Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis. Science 350, 1251-1255. DOI |
20 | Gu, X., Karp, P.H., Brody, S.L., Pierce, R.A., Welsh, M.J., Holtzman, M.J., and Ben-Shahar, Y. (2014). Chemosensory functions for pulmonary neuroendocrine cells. Am. J. Respir. Cell Mol. Biol. 50, 637-646. DOI |
21 | Ichimura, A., Kadowaki, T., Narukawa, K., Togiya, K., Hirasawa, A., and Tsujimoto, G. (2008). In silico approach to identify the expression of the undiscovered molecules from microarray public database: identification of odorant receptors expressed in non-olfactory tissues. Naunyn Schmiedebergs Arch. Pharmacol. 377, 159-165. DOI |
22 | Imai, T., Suzuki, M., and Sakano, H. (2006). Odorant receptorderived cAMP signals direct axonal targeting. Science 314, 657-661. DOI |
23 | Kaji, I., Karaki, S., and Kuwahara, A. (2011). Effects of luminal thymol on epithelial transport in human and rat colon. Am. J. Physiol. Gastrointest. Liver Physiol. 300, G1132-1143. DOI |
24 | Kalbe, B., Knobloch, J., Schulz, V.M., Wecker, C., Schlimm, M., Scholz, P., Jansen, F., Stoelben, E., Philippou, S., Hecker, E., et al. (2016). Olfactory Receptors Modulate Physiological Processes in Human Airway Smooth Muscle Cells. Front. Physiol. 7, 339. |
25 | Kato, A., Katada, S., and Touhara, K. (2008). Amino acids involved in conformational dynamics and G protein coupling of an odorant receptor: targeting gain-of-function mutation. J. Neurochem. 107, 1261-1270. DOI |
26 | Kidd, M., Modlin, I.M., Gustafsson, B.I., Drozdov, I., Hauso, O., and Pfragner, R. (2008). Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants. Am. J. Physiol. Gastrointest. Liver Physiol. 295, G260-272. DOI |
27 | Miyamichi, K., Serizawa, S., Kimura, H.M., and Sakano, H. (2005). Continuous and overlapping expression domains of odorant receptor genes in the olfactory epithelium determine the dorsal/ventral positioning of glomeruli in the olfactory bulb. J. Neurosci. 25, 3586-3592. DOI |
28 | Kobayakawa, K., Kobayakawa, R., Matsumoto, H., Oka, Y., Imai, T., Ikawa, M., Okabe, M., Ikeda, T., Itohara, S., Kikusui, T., et al. (2007). Innate versus learned odour processing in the mouse olfactory bulb. Nature 450, 503-508. DOI |
29 | Margolis, F. (1980). A marker protein for the olfactory chemoreceptor neuron. In Proteins of the nervous system, R.A. Bradshaw, D. Schneider eds. (Newyork, America: Raven Press), pp. 59-84. |
30 | Massberg, D., Simon, A., Haussinger, D., Keitel, V., Gisselmann, G., Conrad, H., and Hatt, H. (2015). Monoterpene (-)-citronellal affects hepatocarcinoma cell signaling via an olfactory receptor. Arch. Biochem. Biophys. 566, 100-109. DOI |
31 | Neuhaus, E.M., Mashukova, A., Barbour, J., Wolters, D., and Hatt, H. (2006). Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. J. Cell. Sci. 119, 3047-3056. DOI |
32 | Neuhaus, E.M., Zhang, W., Gelis, L., Deng, Y., Noldus, J., and Hatt, H. (2009). Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. J. Biol. Chem. 284, 16218-16225. DOI |
33 | Nguyen, M.Q., Zhou, Z., Marks, C.A., Ryba, N.J., and Belluscio, L. (2007). Prominent roles for odorant receptor coding sequences in allelic exclusion. Cell 131, 1009-1017. DOI |
34 | Pal, K., Badgandi, H., and Mukhopadhyay, S. (2015). Studying G protein-coupled receptors: immunoblotting, immunoprecipitation, phosphorylation, surface labeling, and cross-linking protocols. Methods Cell Biol. 127, 303-322. |
35 | Pilpel, Y., and Lancet, D. (1999). The variable and conserved interfaces of modeled olfactory receptor proteins. Protein Sci. 8, 969-977. DOI |
36 | Palczewski, K., Kumasaka, T., Hori, T., Behnke, C.A., Motoshima, H., Fox, B.A., Le Trong, I., Teller, D.C., Okada, T., Stenkamp, R.E., et al. (2000). Crystal structure of rhodopsin: A G protein-coupled receptor. Science 289, 739-745. DOI |
37 | Park, C., Choi, W.S., Kwon, H., and Kwon, Y.K. (2001). Temporal and spatial expression of neurotrophins and their receptors during male germ cell development. Mol. Cells 12, 360-367. |
38 | Persson, H., Ayer-Le Lievre, C., Soder, O., Villar, M.J., Metsis, M., Olson, L., Ritzen, M., and Hokfelt, T. (1990). Expression of beta-nerve growth factor receptor mRNA in Sertoli cells downregulated by testosterone. Science 247, 704-707. DOI |
39 | Probst, W.C., Snyder, L.A., Schuster, D.I., Brosius, J., and Sealfon, S.C. (1992). Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol. 11, 1-20. DOI |
40 | Ressler, K.J., Sullivan, S.L., and Buck, L.B. (1994). Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell 79, 1245-1255. DOI |
41 | Ronnett, G.V., Hester, L.D., and Snyder, S.H. (1991). Primary culture of neonatal rat olfactory neurons. J. Neurosci. 11, 1243-1255. DOI |
42 | Serizawa, S., Miyamichi, K., and Sakano, H. (2004). One neuron-one receptor rule in the mouse olfactory system. Trends Genet. 20, 648-653. DOI |
43 | Serizawa, S., Miyamichi, K., Takeuchi, H., Yamagishi, Y., Suzuki, M., and Sakano, H. (2006). A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting. Cell 127, 1057-1069. DOI |
44 | Vanderhaeghen, P., Schurmans, S., Vassart, G., and Parmentier, M. (1993). Olfactory receptors are displayed on dog mature sperm cells. J. Cell Biol. 123, 1441-1452. DOI |
45 | Sherman, M.A., and Lesne, S.E. (2011). Detecting abeta*56 oligomers in brain tissues. Methods Mol. Biol. 670, 45-56. |
46 | Spehr, J., Gelis, L., Osterloh, M., Oberland, S., Hatt, H., Spehr, M., and Neuhaus, E.M. (2011). G protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. J. Biol. Chem. 286, 13184-13192. DOI |
47 | Spehr, M., Gisselmann, G., Poplawski, A., Riffell, J.A., Wetzel, C.H., Zimmer, R.K., and Hatt, H. (2003). Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 299, 2054-2058. DOI |
48 | Strotmann, J., Levai, O., Fleischer, J., Schwarzenbacher, K., and Breer, H. (2004). Olfactory receptor proteins in axonal processes of chemosensory neurons. J. Neurosci. 24, 7754-7761. DOI |
49 | Takeuchi, H., Inokuchi, K., Aoki, M., Suto, F., Tsuboi, A., Matsuda, I., Suzuki, M., Aiba, A., Serizawa, S., Yoshihara, Y., et al. (2010). Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map topography at the bulb. Cell 141, 1056-1067. DOI |
50 | Vassar, R., Ngai, J., and Axel, R. (1993). Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell 74, 309-318. DOI |
51 | Zhang, X., De la Cruz, O., Pinto, J.M., Nicolae, D., Firestein, S., and Gilad, Y. (2007). Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray. Genome Biol. 8, R86. DOI |
52 | Veitinger, T., Riffell, J.R., Veitinger, S., Nascimento, J.M., Triller, A., Chandsawangbhuwana, C., Schwane, K., Geerts, A., Wunder, F., Berns, M.W., et al. (2011). Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm. J. Biol. Chem. 286, 17311-17325. DOI |
53 | Walensky, L.D., Roskams, A.J., Lefkowitz, R.J., Snyder, S.H., and Ronnett, G.V. (1995). Odorant receptors and desensitization proteins colocalize in mammalian sperm. Mol. Med. 1, 130-141. |
54 | Wu, C., Jia, Y., Lee, J.H., Kim, Y., Sekharan, S., Batista, V.S., and Lee, S.J. (2015). Activation of OR1A1 suppresses PPAR-gamma expression by inducing HES-1 in cultured hepatocytes. Int. J. Biochem. Cell Biol. 64, 75-80. DOI |
55 | Zhao, W., Ho, L., Varghese, M., Yemul, S., Dams-O'Connor, K., Gordon, W., Knable, L., Freire, D., Haroutunian, V., and Pasinetti, G.M. (2013). Decreased level of olfactory receptors in blood cells following traumatic brain injury and potential association with tauopathy. J. Alzheimers Dis. 34, 417-429. DOI |