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http://dx.doi.org/10.14348/molcells.2017.0172

Mitochondrial Uncoupling Attenuates Age-Dependent Neurodegeneration in C. elegans  

Cho, Injeong (Department of Biology Education, College of Education, Chosun University)
Song, Hyun-Ok (Department of Infection Biology, Wonkwang University School of Medicine)
Cho, Jeong Hoon (Department of Biology Education, College of Education, Chosun University)
Publication Information
Molecules and Cells / v.40, no.11, 2017 , pp. 864-870 More about this Journal
Abstract
The uncoupling protein 4 (ucp-4) gene is involved in age-dependent neurodegeneration in C. elegans. Therefore, we aimed to investigate the mechanism underlying the association between mitochondrial uncoupling and neurodegeneration by examining the effects of uncoupling agents and ucp-4 overexpression in C. elegans. Treatment with either DNP or CCCP improved neuronal defects in wild type during aging. Uncoupling agents also restored neuronal phenotypes of ucp-4 mutants to those exhibited by wild type, while ucp-4 overexpression attenuated the severity of age-dependent neurodegeneration. Neuronal improvements were further associated with reductions in mitochondrial membrane potentials. However, these age-dependent neuroprotective effects were limited in mitophagy-deficient mutant, pink-1, background. These results suggest that membrane uncoupling can attenuate age-dependent neurodegeneration by stimulating mitophagy.
Keywords
aging; C. elegans; mitophagy; neurodegeneration; uncoupling;
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