BK Knockout by TALEN-Mediated Gene Targeting in Osteoblasts: KCNMA1 Determines the Proliferation and Differentiation of Osteoblasts |
Hei, Hongya
(Department of Pharmacology, School of Pharmacy, Fudan University)
Gao, Jianjun (Department of Bone Metabolism, Institute of Radiation Medicine, Fudan University) Dong, Jibin (Department of Pharmacology, School of Pharmacy, Fudan University) Tao, Jie (Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine) Tian, Lulu (Department of Pharmacology, School of Pharmacy, Fudan University) Pan, Wanma (Department of Pharmacology, School of Pharmacy, Fudan University) Wang, Hongyu (Department of Pharmacy, Shenyang Pharmaceutical University) Zhang, Xuemei (Department of Pharmacology, School of Pharmacy, Fudan University) |
1 | Bentzen, B.H., Olesen, S.P., Ronn, L.C., and Grunnet, M. (2014). BK channel activators and their therapeutic perspectives. Front. Physiol. 5, 389. |
2 | Black, J.A., and Waxman, S.G. (2013). Noncanonical roles of voltage-gated sodium channels. Neuron 80, 280-291. DOI |
3 | Bruderer, M., Richards, R.G., Alini, M., and Stoddart, M.J. (2014). Role and regulation of RUNX2 in osteogenesis. Eur. Cells Mater. 28, 269-286. DOI |
4 | Chen, J., Zhang, W., Lin, J., Wang, F., Wu, M., Chen, C., Zheng, Y., Peng, X., Li, J., and Yuan, Z. (2014). An efficient antiviral strategy for targeting hepatitis B virus genome using transcription activator-like effector nucleases. Mol. Ther. 22, 303-311. DOI |
5 |
Chen, Q., Tao, J., Hei, H., Li, F., Wang, Y., Peng, W., and Zhang, X. (2015). Up-regulatory effects of curcumin on large conductance |
6 | Contreras, G.F., Castillo, K., Enrique, N., Carrasquel-Ursulaez, W., Castillo, J.P., Milesi, V., Neely, A., Alvarez, O., Ferreira, G., Gonzalez, C., et al. (2013). A BK (Slo1) channel journey from molecule to physiology. Channels 7, 442-458. DOI |
7 | Fernandez-Marino, A.I., Cidad, P., Zafra, D., Nocito, L., Dominguez, J., Olivan-Viguera, A., Kohler, R., Lopez-Lopez, J.R., Perez-Garcia, M.T., Valverde, M.A., et al. (2015). Tungstate-targeting of BKalphabeta1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle. PLoS One 10, e0118148. DOI |
8 | Henney, N.C., Li, B., Elford, C., Reviriego, P., Campbell, A.K., Wann, K.T., and Evans, B.A. (2009) A large-conductance (BK) potassium channel subtype affects both growth and mineralization of human osteoblasts. Am. J. Physiol. Cell Physiol. 297, C1397-1408. DOI |
9 | Hirukawa, K., Muraki, K., Ohya, S., Imaizumi, Y., and Togari, A. (2008). Electrophysiological properties of a novel Ca(2+)-activated K(+) channel expressed in human osteoblasts. Calcif. Tissue Int. 83, 222-229. DOI |
10 |
Huang, H., Rao, Y., Sun, P., and Gong, L.W. (2002). Involvement of actin cytoskeleton in modulation of Ca21-activated |
11 |
Issa, N.P., and Hudspeth, A.J. (1994) Clustering of |
12 | Jin, W., Sugaya, A., Tsuda, T., Ohguchi, H., and Sugaya, E. (2000). Relationship between large conductance calcium-activated potassium channel and bursting activity. Brain Res. 860, 21-28. DOI |
13 | Kim, E.Y., Suh, J.M., Chiu, Y.H., and Dryer, SE. (2010). Regulation of podocyte BKCa channels by synaptopodin, Rho, and actin microfilament. Am. J. Physiol. 299, F594-F604. |
14 | Long, F. (2012). Building strong bones: molecular regulation of the osteoblast lineage. Nat. Rev. Mol. Cell Biol. 13, 27-38. DOI |
15 | Lu, P., Chen, J., He, L., Ren, J., Chen, H., Rao, L., Zhuang, Q., Li, H., Li, L., Bao, L., et al. (2013). Generating hypoimmunogenic human embryonic stem cells by the disruption of beta 2-microglobulin. Stem Cell Rev. 9, 806-813. DOI |
16 | Mehranfard, N., Gholamipour-Badie, H., Motamedi, F., Janahmadi, M., and Naderi, N. (2015). Long-term increases in BK potassium channel underlie increased action potential firing in dentate granule neurons following pilocarpine-induced status epilepticus in rats. Neurosci. Lett. 585, 88-91. DOI |
17 | Morera, F.J., Saravia, J., Pontigo, J.P., Vargas-Chacoff, L., Contreras, G.F., Pupo, A., Lorenzo, Y., Castillo, K., Tilegenova, C., Cuello, L.G., et al. (2015). Voltage-dependent BK and Hv1 channels expressed in non-excitable tissues: New therapeutics opportunities as targets in human diseases. Pharmacol Res. 101, 56-64. DOI |
18 | Petkov, G.V. (2014). Central role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology. Am. J. Physiol. R 307, R571-584. |
19 | Sandow, S.L., and Grayson, T.H. (2009). Limits of isolation and culture: intact vascular endothelium and BKCa. Am. J. Physiol. Heart Circ. Physiol. 297, H1-H7. DOI |
20 | Sausbier, U., Dullin, C., Missbach-Guentner, J., Kabagema, C., Flockerzie, K., Kuscher, G.M., Stuehmer, W., Neuhuber, W., Ruth, P., Alves, F., et al. (2011). Osteopenia due to enhanced cathepsin K release by BK channel ablation in osteoclasts. PLoS One 6, e21168. DOI |
21 | Shen, R., Wang, X., Drissi, H., Liu, F., O'Keefe, R.J., and Chen, D. (2006). Cyclin D1-cdk4 induce runx2 ubiquitination and degradation. J. Biol. Chem. 281, 16347-16353. DOI |
22 | Tokuda, S., and Furuse, M. (2015). Claudin-2 knockout by TALENmediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells. PLoS One 10, e0119869. DOI |
23 | Wu, R.S., and Marx, S.O. (2010). The BK potassium channel in the vascular smooth muscle and kidney: alpha-and beta-subunits. Kidney Int. 78, 963-974. DOI |
24 | Wu, Z., Yin, H., Liu, T., Yan, W., Li, Z., Chen, J., Chen, H., Wang, T., Jiang, Z., Zhou, W., et al. (2014) MiR-126-5p regulates osteoclast differentiation and bone resorption in giant cell tumor through inhibition of MMP-13. Biochem. Biophys. Res. Commun. 443, 944-949. DOI |
25 | Yamamura, H., Ikeda, C., Suzuki, Y., Ohya, S., and Imaizumi, Y. (2012). Molecular assembly and dynamics of fluorescent proteintagged single KCa1.1 channel in expression system and vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 302, C1257-C1268. DOI |
26 | Yen, T.Y., Li, K.P., Ou, S.C., Shien, J.H., Lu, H.M., and Chang, P.C. (2015). Construction of an infectious plasmid clone of Muscovy duck parvovirus by TA cloning and creation of a partially attenuated strain. Avian Pathol. 44, 124-128. DOI |
27 | Yu, S., Yerges-Armstrong, L.M., Chu, Y., Zmuda, J.M., and Zhang, Y. (2013). E2F1 effects on osteoblast differentiation and mineralization are mediated through up-regulation of frizzled-1. Bone 56, 234-241. DOI |
28 | Zhang, Y.Y., Yue, J., Che, H., Sun, H.Y., Tse, H.F., and Li, G.R. (2014). BKCa and hEag1 channels regulate cell proliferation and differentiation in human bone marrow-derived mesenchymal stem cells. J. Cell. Physiol. 229, 202-212. DOI |
![]() |